Anti-Citrullinated Protein Antibodies

Autoantibodies to citrullinated-peptides and proteins.

Also Known As:

Anti-CCP; Anti-Citrullinated Peptide Antibodies; Anti-Cyclic Citrullinated Protein Antibodies; Citrullinated Protein Antibodies; Cyclic Citrullinated Peptide Antibodies; Anti CCP; Anti Citrullinated Peptide Antibodies; Anti Citrullinated Protein Antibodies; Anti Citrullinated Protein Antibody; Anti Citrullinated Protein Autoantibodies; Anti Cyclic Citrullinated Protein Antibodies; Antibody, Anti-Citrullinated Protein; Antibody, Citrullinated Protein; Anti-Citrullinated Protein Antibody; Anti-Citrullinated Protein Autoantibodies; Citrullinated Protein Antibody; Citrullinated Protein Autoantibodies

Networked: 1535 relevant articles (42 outcomes, 185 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Klareskog, Lars: 41 articles (11/2022 - 08/2007)
2.	Huizinga, Tom W J: 38 articles (01/2022 - 07/2004)
3.	Alfredsson, Lars: 29 articles (01/2022 - 08/2007)
4.	van Schaardenburg, Dirkjan: 28 articles (01/2022 - 10/2002)
5.	Toes, René E M: 27 articles (01/2019 - 07/2004)
6.	Robinson, William H: 26 articles (04/2022 - 01/2008)
7.	Deane, Kevin D: 22 articles (01/2022 - 01/2005)
8.	Holers, V Michael: 22 articles (01/2022 - 01/2005)
9.	Padyukov, Leonid: 20 articles (01/2021 - 08/2007)
10.	Rönnelid, Johan: 19 articles (11/2022 - 04/2009)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2017 - "Anti-citrullinated peptide antibodies are the strongest predictor of clinically relevant radiographic progression in rheumatoid arthritis patients achieving remission or low disease activity: A post hoc analysis of a nationwide cohort in Japan." 10/01/2010 - "Radiographic progression and remission rates in early rheumatoid arthritis - MRI bone oedema and anti-CCP predicted radiographic progression in the 5-year extension of the double-blind randomised CIMESTRA trial." 07/01/2023 - "There is an increasing body of evidence suggesting a direct pathophysiological role of anti-citrullinated peptide antibodies (ACPA) in rheumatoid arthritis (RA), and immunological remission could be a target for treatment. " 11/12/2020 - "Fluctuation in anti-cyclic citrullinated protein antibody level predicts relapse from remission in rheumatoid arthritis: KURAMA cohort." 01/01/2017 - "Persistence of Disease-Associated Anti-Citrullinated Protein Antibody-Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission."
2.	Arthritis (Polyarthritis) 05/01/2017 - "Since the previous studies showed that anti-citrullinated protein antibodies (ACPA) can induce osteoclasts differentiation and activation, even before arthritis onset, the aim of our study was to determine whether ACPA-positivity is associated with lower bone mineral density (BMD) at baseline visit of a register of early arthritis (EA) patients. " 07/01/2013 - "The study analyzed 45 SLE patients, 139 RA patients and 147 normal subjects by measuring RF and anti-CCP2 titers and comparing/correlating inter-groups or subgroups divided by criteria such as arthritis and RF/anti-CCP positivity. " 12/01/2006 - "This study was undertaken to determine anti-CCP isotype usage in patients with undifferentiated arthritis (UA), patients with recent-onset RA, and patients with RA of long duration. " 01/02/2023 - "Increased CRP, anti-CCP antibody, IL-2R, COMP levels in prognosis of post-chikungunya chronic arthritis and protective role of their specific genotypes against arthritic manifestation." 04/20/2022 - "It is important to note that patients with chronic arthritis, as well as those with anti-CCP antibody-positive polyarthritis, should be carefully followed for their clinical and serological condition, considering the possibility of them developing juvenile SLE."
3.	Rheumatic Diseases (Rheumatism) 01/01/2017 - "Clinical outcomes (European League Against Rheumatism (EULAR) response, mean Clinical Disease Activity Index (CDAI) and Boolean remission) at 6 months were compared by baseline RF and anti-CCP status. " 11/06/2023 - "This study aimed to determine the cutoff values for RF and anti-CCP with the best diagnostic performance in a sample of patients with RA, compared with other rheumatic diseases. " 10/01/2018 - "The frequency of anti-CCP was similar between QUANTA Flash CCP3 and the other CCP2 assays in the RA (67.2% vs. 62.7-70.1%), other rheumatic diseases (7.8% vs. 6.3%), and OA (2.3% vs. 0-2.3%) groups. " 09/01/2016 - "Serum concentrations of RF and anti-CCP were measured in 246 cases, including 39 patients with RA and 207 patients with other rheumatic diseases (non-RA). " 03/01/2013 - "The test results of 3,503 patients from the outpatient clinic of The Hospital for Rheumatic Diseases who underwent test for RF, APF, anti-CCP and anti-MTOC-MT simultaneously for the work-up of RA were analyzed. "
4.	Synovitis 10/01/2020 - "The nomogram incorporating anti-CCP, SDAI, and subclinical synovitis helps to achieve complete remission and reduces the risk of short-term recurrence of RA patients." 01/01/2021 - "Anti-CCP positive at-risk individuals without clinical synovitis appear to have a distinct gut microbiome compared with healthy controls. " 01/01/2019 - "Thirty-one percent of patients with low clinical disease activity exhibited histologic evidence of subclinical synovitis, which was associated with increased CRP and anti-CCP levels. " 01/01/2018 - "Anti-cyclic citrullinated protein antibodies(ACPA)was recognized not only as a diagnostic marker but also as direct inducer of synovitis. " 12/01/2016 - "In a prospective study, 20 patients with anti-CCP-positive RA and 20 patients with anti-CCP-negative RA with active wrist synovitis were examined. "
5.	Pain (Aches) 06/01/2015 - "Symmetrical joint involvement, anti-CCP positivity and fewer tender joints at baseline are prognostic signs for achieving satisfactory improvement in pain after 6 months of treat to target in patients with early RA." 01/01/2022 - "In anti-CCP- patients, those with hand or knee pain were at increased risk of progression. " 01/01/2022 - "In patients with low anti-CCP level and no pain in the hands/feet, progression is unlikely. " 01/01/2022 - "High anti-CCP levels and pain in hands/feet indicated an increased likelihood of progression to IA. " 01/01/2021 - "Non-inflammatory long-lasting pain appears to be a greater problem in anti-CCP-negative patients."

Related Drugs and Biologics

1.	Antibodies
2.	Rheumatoid Factor
3.	cyclic citrullinated peptide
4.	Abatacept (Orencia)
5.	Antirheumatic Agents (DMARD)
6.	Immunoglobulin M (IgM)
7.	Anti-Citrullinated Protein Antibodies
8.	Autoantibodies
9.	C-Reactive Protein
10.	Enzymes

Related Therapies and Procedures

1.	Precision Medicine
2.	Intra-Articular Injections
3.	Injections
4.	Biological Therapy
5.	Therapeutics