Receptors for Activated C Kinase

Receptors for PROTEIN KINASE C that consist of seven WD40 REPEATS. They function in a wide variety of cellular and physiologic processes including the assembly of signaling complexes, protein translation, cell growth and proliferation, APOPTOSIS, and MUSCARINIC RECEPTOR transport. RACK1 depends on protein kinase C activity to translocate from the perinuclear region to the cell periphery and associates with the plasma membrane through interactions with KERATIN-1 and INTEGRIN BETA-1.

Also Known As:

Networked: 106 relevant articles (2 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Buoso, Erica: 4 articles (01/2022 - 01/2019)
2.	Gu, Jianxin: 4 articles (01/2022 - 01/2013)
3.	Racchi, Marco: 4 articles (01/2022 - 01/2019)
4.	Ruan, Yuanyuan: 4 articles (01/2022 - 01/2013)
5.	Masi, Mirco: 3 articles (01/2022 - 12/2020)
6.	Wang, Lan: 3 articles (01/2022 - 01/2013)
7.	Zhang, Jiyan: 3 articles (01/2021 - 01/2013)
8.	Corsini, Emanuela: 3 articles (12/2020 - 01/2019)
9.	Chen, Qianming: 3 articles (01/2020 - 04/2012)
10.	Jiang, Lu: 3 articles (01/2020 - 04/2012)

Related Diseases

1.	Neoplasms (Cancer) 08/14/2023 - "As a tumor suppressor for GC, whether receptor for activated C-kinase 1 (RACK1) play a modulatory role in metabolic reprogramming remains largely unclear. " 01/01/2023 - "The receptor for activated C kinase 1 (RACK1) expression is associated with clinicopathological characteristics and the prognosis of various cancers; however, the conclusions are controversial. " 01/01/2018 - "NEW & NOTEWORTHY Our findings reveal novel functions for receptor for activated C kinase 1 (Rack1) in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia." 11/01/2011 - "Downregulation of receptor for activated C-kinase 1 (RACK1) suppresses tumor growth by inhibiting tumor cell proliferation and tumor-associated angiogenesis." 04/01/2002 - "Differentially expressed transcripts included genes known to be important in neocortical development (e.g., brain factor 1, neuroD2, and Id2), genes not previously associated with neocortical development (such as brahma-related gene 1, receptor for activated C-kinase I, hypermethylated in cancer 2, and Evi9), and genes of unknown identity or function."
2.	Infections 05/01/2001 - "donovani infection were stimulated in vitro with LACK, the Leishmania homologue of receptors for activated C kinase. " 02/01/1998 - "Recent reports have suggested that after infection of BALB/c mice with Leishmania major, CD4+ T cells responding to a single antigen, LACK (Leishmania homologue of receptors for activated C kinase), drive the differentiation of other responding T cells to the Th2 phenotype and so allow lesion development to occur. " 01/01/2009 - "Following Leishmania major infection, the early LACK (Leishmania homolog of receptors for activated C kinase)-induced IL-4 response appears to determine disease susceptibility in BALB/c mice. " 08/01/2005 - "This study reports the efficacy of a heterologous prime-boost vaccination using DNA and vaccinia viruses (Western Reserve [WR] virus and modified [attenuated] vaccinia virus Ankara [MVA]) expressing the LACK antigen (Leishmania homologue of receptors for activated C kinase) and an intradermal murine infection model employing Leishmania infantum. " 03/01/2000 - "Susceptibility of BALB/c mice to Leishmania major infection has been correlated to the preferential development of Th2 CD4 T cells through an early production of interleukin 4 (IL-4) by a restricted population of CD4 T cells which react to a single parasite antigen, LACK (stands for Leishmania homologue of receptors for activated C kinase). "
3.	Squamous Cell Carcinoma of Head and Neck 03/01/2023 - "This study is to evaluate the effect of receptor for activated c kinase 1 (RACK1) and peripheral blood M2/M1 monocytes ratio on the prognosis of patients with oral squamous cell carcinoma (OSCC). " 08/01/2016 - "Our previous study suggested that receptor for activated C kinase 1 (RACK1) contribute to the progression of oral squamous cell carcinoma (OSCC). " 10/01/2022 - "To explore the relationship between combined detection of tissue active protein kinase C receptor 1 (RACK1) and M2/M1 and the prognosis of oral squamous cell carcinoma (OSCC). " 01/01/2020 - "Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell carcinoma (OSCC) progression, and RACK1 expression levels have been negatively correlated with prognosis in patients with OSCC. " 04/01/2012 - "Receptor for activated C kinase 1 (RACK1): a regulator for migration and invasion in oral squamous cell carcinoma cells."
4.	Hepatocellular Carcinoma (Hepatoma) 01/01/2018 - "Our previous study indicated that ribosomal receptor for activated C-kinase 1 (RACK1) promoted chemoresistance and growth in hepatocellular carcinoma (HCC). " 12/01/2016 - "The present study reports that knockdown of endogenous receptor for activated C kinase 1 (RACK1) increases the intracellular ROS level following TNF-α or H2O2 stimulation in human hepatocellular carcinoma (HCC) cells, leading to promotion of cell death. " 01/01/2018 - "This review describes the crucial role of ribosomes in various common malignant tumors; in particular, it examines the effects of RPs, including S6, the receptor for activated C-kinase and RPS15A, on the development and progression of hepatocellular carcinoma." 06/01/2015 - "Receptor for activated C kinase 1 (RACK1) is up-regulated in hepatocellular carcinoma (HCC) and has been reported to augment c-Jun N-terminal protein kinase (JNK) activity in HCC SMMC-7721 cells. " 01/01/2013 - "Receptor for activated C kinase 1 promotes hepatocellular carcinoma growth by enhancing mitogen-activated protein kinase kinase 7 activity."
5.	Stomach Neoplasms (Stomach Cancer) 01/01/2019 - "Purpose: As there have been few studies on the effects of the receptor for activated C kinase 1 (RACK1) on gastric cancer (GC), we aimed to explore such effects and the mechanism that may be involved. " 09/15/2015 - "In this study, we found that loss of the receptor for activated C-kinase 1 (RACK1) promoted the metastasis of gastric cancer by enhancing the autocrine expression of IL8 in vitro and in vivo. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	DNA (Deoxyribonucleic Acid)
3.	Leishmania LACK antigen
4.	Protein Kinase C
5.	Proteins (Proteins, Gene)
6.	Antigens
7.	Vaccines
8.	Protein Kinase C-epsilon
9.	Cytokines
10.	CXCR4 Receptors (CXCR4 Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Prostatectomy (Retropubic Prostatectomy)
4.	Drug Therapy (Chemotherapy)