Median Arcuate Ligament Syndrome

Compression of the CELIAC ARTERY by the median arcuate ligament, a fibrous band of the DIAPHRAGM, causing abdominal pain after eating and weight loss. OMIM: 116870

Also Known As:

Celiac Artery Compression Syndrome; Celiac Artery Stenosis from Compression by Median Arcuate Ligament of Diaphragm; Celiac Trunk Compression Syndrome; Dunbar Syndrome; Syndrome, Dunbar

Networked: 71 relevant articles (7 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abdominal Pain (Pain, Abdominal)
2.	Visceral Pain
3.	Postoperative Pain
4.	Pathologic Constriction (Stenosis)
5.	Aneurysm (Aneurysms)

Experts

1.	Matsumoto, Kenji: 2 articles (05/2024 - 05/2022)
2.	Sata, Naohiro: 2 articles (05/2024 - 05/2022)
3.	Shinozaki, Hiroharu: 2 articles (05/2024 - 05/2022)
4.	Shinozaki, Satoshi: 2 articles (05/2024 - 05/2022)
5.	Terauchi, Toshiaki: 2 articles (05/2024 - 05/2022)
6.	Bruno, Marco J: 2 articles (01/2024 - 11/2022)
7.	Geelkerken, Robert H: 2 articles (01/2024 - 11/2022)
8.	Artaş, Hakan: 2 articles (03/2022 - 09/2018)
9.	Karabulut, Koray: 2 articles (03/2022 - 09/2018)
10.	Usta, Sertaç: 2 articles (03/2022 - 09/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Median Arcuate Ligament Syndrome:

1.	purpurate-3,3'-diacetic acidIBA 09/01/2023 - "The findings from this case report represent a novel treatment strategy for the management of PDAA/GDAA with celiac artery compression secondary to median arcuate ligament syndrome." 12/01/2023 - "Based on the imaging findings, it was diagnosed that PDAA was ruptured, SMA developed segmental arterial mediolysis (SAM), and CA developed median arcuate ligament syndrome (MALS). " 09/01/2023 - "Here, we describe a 62-year-old female with PDAA and GDAA complicated by celiac artery occlusion due to median arcuate ligament syndrome. " 08/04/2021 - "Herein, we report two cases of PDAA caused by the median arcuate ligament syndrome, treated with surgical revascularization by aortosplenic bypass followed by coil embolization. " 05/17/2019 - "A pancreaticoduodenal artery aneurysm (PDAA) occurring in close association with median arcuate ligament syndrome (MALS) is rare. "
2.	Morphine (MS Contin)FDA LinkGeneric 03/01/2008 - "Median arcuate ligament syndrome--a novel treatment using an intrathecal morphine pump to relieve intractable visceral pain."
3.	salicylhydroxamic acid (SHAM)IBA 11/01/2022 - "Coeliac Artery Release or Sham Operation in Patients Suspected of Having Median Arcuate Ligament Syndrome: The CARoSO study."
4.	Phenobarbital (Luminal)FDA Link 12/01/2010 - "Median arcuate ligament syndrome (MALS) is a rare disorder resulting from luminal narrowing of the celiac artery by the insertion of the diaphragmatic muscle fibers. " 07/01/2009 - "Celiac artery compression syndrome (CACS) is an unusual condition caused by abnormally low insertion of the median fibrous arcuate ligament and muscular diaphragmatic fiber resulting in luminal narrowing of the celiac trunk. " 02/01/2008 - "Median arcuate ligament syndrome is a rare disorder resulting from luminal narrowing of the celiac trunk. " 05/01/2005 - "Median arcuate ligament syndrome is a rare disorder resulting from luminal narrowing of the celiac artery by the insertion of the diaphragmatic muscle fibers or fibrous bands of the celiac nervous plexus. " 01/01/2014 - "A 63 year old female presented to the emergency department with a several month history of intermittent right upper quadrant abdominal pain, early satiety with loss of appetite, and an unintentional weight loss of 8. She underwent a battery of tests that returned negative and subsequently sent for Computed tomographic angiography (CTA) of the abdomen revealing luminal stenosis of the proximal 1 cm of the celiac axis estimating 90% occlusion and a patent SMA and IMA with, typical for median arcuate ligament syndrome. "
5.	Vasodilator Agents (Vasodilators)IBA 02/01/2009 - "Definitive test to diagnose median arcuate ligament syndrome: injection of vasodilator during angiography."
6.	Narcotics (Narcotic Analgesics)IBA 03/01/2008 - "The use of an intrathecal narcotic pump should be considered for treatment of patients with intractable visceral pain secondary to median arcuate ligament syndrome."
7.	Glutathione Transferase (Glutathione S-Transferase)IBA 01/01/2022 - "Plasma α-Glutathione S-Transferase in Patients with Chronic Mesenteric Ischemia and Median Arcuate Ligament Syndrome."
8.	Opioid Analgesics (Opioids)IBA 01/01/2023 - "Median arcuate ligament syndrome patients who had a pre-operative pain management consultation had higher rates of pre-operative opioid (35.5%; p = 0.01) and non-opioid use (60.7%; p < 0.001). "
9.	Gabapentin (Neurontin)FDA LinkGeneric 06/01/2022 - "Gabapentin as a Symptomatic Modifier in Median Arcuate Ligament Syndrome: A Case Report and Assessment of Treatment Modalities."

Therapies and Procedures

1.	Decompression 07/01/2009 - "Celiac artery compression syndrome (CACS) remains a controversial diagnosis, despite several reported series documenting therapeutic efficacy of CA decompression. " 05/11/2024 - "The study aimed at evaluating the outcomes in patients who underwent median arcuate ligament syndrome decompression using a self-report questionnaire. " 05/11/2024 - "This single-center retrospective study included patients with median arcuate ligament syndrome who underwent decompression surgery between April 2021 and February 2023. " 08/01/2021 - "Detailed anatomy and procedure of celiac artery decompression in median arcuate ligament syndrome." 09/06/2019 - "We present a case of a 55-year-old woman with celiac artery compression syndrome treated by laparoscopic decompression of the median arcuate ligament."
2.	Stents 09/01/2023 - "The efficacy of endovascular therapy (EVT) using stents for the invasive treatment of celiac artery compression syndrome (CACS) resulting from the compression of the median arcuate ligament has not yet been established. " 09/01/2023 - "Effectiveness of endovascular therapy using stents in a patient with celiac artery compression syndrome due to the median arcuate ligament: A case report." 02/01/2024 - "He subsequently developed stent fracture and celiac artery occlusion secondary to previously unrecognized median arcuate ligament syndrome causing reperfusion of the aneurysm. " 01/01/2022 - "Celiac Artery Dissection and Retroperitoneal Hemorrhage in Median Arcuate Ligament Syndrome Treated With a Stent and Transcatheter Arterial Embolization: Preprocedural 4-Dimensional Computed Tomography Angiography Assessment." 03/01/2010 - "Treatment of the celiac artery compression syndrome is primarily surgical, but stent insertion may have a role as a secondary procedure where there is a residual stenosis after median arcuate ligament division."
3.	Therapeutics 08/29/2017 - "Here we aimed to evaluate the central priority of open vascular therapy in the treatment of median arcuate ligament syndrome. " 11/01/2009 - "Median arcuate ligament syndrome: vascular surgical therapy and follow-up of 18 patients." 10/01/2009 - "Although the indication for surgical therapy is controversially discussed in the literature for celiac artery compression syndrome, it is unequivocally for renal artery entrapment. " 09/01/2023 - "The efficacy of endovascular therapy (EVT) using stents for the invasive treatment of celiac artery compression syndrome (CACS) resulting from the compression of the median arcuate ligament has not yet been established. " 09/01/2023 - "Effectiveness of endovascular therapy using stents in a patient with celiac artery compression syndrome due to the median arcuate ligament: A case report."
4.	Minimally Invasive Surgical Procedures 10/01/2022 - "Median Arcuate Ligament Syndrome is Effectively Relieved with Minimally Invasive Surgery." 01/01/2016 - "Between 2013 and 2016 in the General and Minimally Invasive Surgery Department of the Medical Sciences Faculty of the University of Warmia and Mazury in Olsztyn, 6 laparoscopic procedures were performed because of median arcuate ligament syndrome. " 05/01/2023 - "Minimally Invasive Surgery for Median Arcuate Ligament Syndrome and Celiac Artery Stenosis."
5.	Ganglionectomy 01/01/2020 - "We present a case of celiac artery compression syndrome in a young female where laparoscopic median arcuate ligament release with celiac ganglionectomy was effective in relieving the symptoms. " 04/01/2021 - "Laparoscopic treatment of median arcuate ligament syndrome without ganglionectomy of the celiac plexus in the hybrid operating room: Report of a case." 11/01/2010 - "Laparoscopic versus open celiac ganglionectomy in patients with median arcuate ligament syndrome."