Thyroid Nuclear Factor 1

A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

Also Known As:

Networked: 346 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Yatabe, Yasushi: 5 articles (01/2022 - 04/2008)
2.	Jirström, Karin: 5 articles (01/2019 - 07/2013)
3.	Wistuba, Ignacio I: 4 articles (01/2022 - 04/2011)
4.	Rossi, Giulio: 4 articles (10/2021 - 06/2011)
5.	Botling, Johan: 4 articles (01/2019 - 11/2014)
6.	Brunnström, Hans: 4 articles (01/2019 - 07/2013)
7.	Kerr, Keith M: 4 articles (01/2019 - 04/2010)
8.	Micke, Patrick: 4 articles (01/2019 - 11/2014)
9.	Papotti, Mauro: 4 articles (01/2019 - 06/2011)
10.	Pelosi, Giuseppe: 4 articles (01/2019 - 06/2011)

Related Diseases

1.	Carcinoma (Carcinomatosis) 10/01/2004 - "To detect the expression of thyroid transcription factor 1 (TTF-1) and study its application in the diagnosis of lung carcinomas. " 03/01/2023 - "Histopathology demonstrated a ruptured small cell neuroendocrine carcinoma in the appendix with thyroid transcription factor 1 positive immunohistochemistry. " 01/01/2023 - "There is no significant difference between thyroid transcription factor 1 (TTF-1) expression in the SC (46.5%, 33/71) of pleomorphic carcinoma with ADC components and pure PSC (44.2%, 42/95) without p40 expression ( P =0.858). " 04/03/2020 - "However, they were negative for caudal type homeobox 2, S100, paired box gene 8, thyroid transcription factor 1, and CD20, which ruled out the origin of gastrointestinal, pancreatic, lung, and Merkel cell carcinomas. " 11/01/2012 - "Thyroid transcription factor 1 (TTF-1) is currently the best immunohistochemical marker for carcinomas of lung origin. "
2.	Small Cell Carcinoma 06/01/2019 - "Thyroid transcription factor 1 (TTF-1) was also included, given its positivity in a subset of small cell carcinomas. " 10/15/2011 - "Thyroid transcription factor 1 (TTF-1) plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinomas. " 09/01/2011 - "Small cell carcinoma of different organs has been shown to express markers of neuroendocrine differentiation, and also thyroid transcription factor 1 (TTF-1). " 07/01/2005 - "Thyroid transcription factor 1 (TTF-1) expression is common in small cell carcinomas arising in the lung. " 07/01/2005 - "Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases."
3.	Wilms Tumor (Wilm's Tumor) 12/01/2021 - "Immunostaining revealed that the tumor cells were negative for thyroid transcription factor 1 but positive for Wilms tumor 1. The tumor additionally exhibited strong membranous CD56 expression and patchy p53 expression, both of which were inconsistent with the characteristics of ovarian HGSC. " 01/01/2011 - "Morphology in association with a small panel of immunostains including thyroid transcription factor 1, estrogen receptor, mammaglobin, Wilms tumor antigen 1, CA125 and CDX2 proved helpful in identifying the primary origin in 94% of cases. " 07/01/2017 - "Calretinin and cytokeratin 5 were used for reactive mesothelial cells and Wilms tumor 1, thyroid transcription factor 1, CDX2, and estrogen receptor were used to confirm the adenocarcinoma cells. " 10/04/2023 - "The epithelial component ranged from a bland appearance in areas diagnostic of adenosarcoma to a clearly invasive carcinoma, both with mesonephric-like phenotype, being negative for estrogen receptor, progesterone receptor, and Wilms' tumor 1, variably positive for paired box gene 8, GATA binding protein 3, and thyroid transcription factor 1, with a wild-type p53 expression. " 09/13/2016 - " stained 45 non-small cell lung cancer samples (32 adenocarcinomas and 13 squamous cell carcinomas) with a monoclonal antibody for BRCA1-associated protein 1 (BAP1) and also with an IHC panel we routinely use to help differentiate MM from carcinomas, which include, calretinin, Wilms Tumor 1, cytokeratin 5, podoplanin D2-40, pankeratin CAM5.2, thyroid transcription factor 1, Napsin-A, and p63. "
4.	Neoplasms (Cancer) 01/01/2016 - "Our previous study using resected tumor tissue has shown that the combination of commonly used individual markers (thyroid transcription factor 1 [TTF-1], P40, and Napsin A) into a novel triple marker has high sensitivity and specificity in subclassification of NSCLC and also the advantage of using minimal tumor tissue. " 06/17/2022 - "Pathologically, all tumors showed thyroid transcription factor 1 immunoreactivity. " 03/28/2022 - "Thyroid transcription factor 1 was positive, whereas paired box gene 8 (Pax8) was negative in tumor cells. " 05/01/2021 - "Immunohistochemical analyses showed that both tumors were positive for thyroid transcription factor 1, supporting a lung primary. " 04/01/2021 - "Posterior pituitary tumours (PPTs) are rare neoplasms with the four recognised subtypes unified by thyroid transcription factor -1 (TTF-1) expression, according to the 2017 WHO classification. "
5.	Adenocarcinoma 08/22/2005 - "This study investigated the relation between positive thyroid transcription factor 1 (TTF1) staining and survival of patients affected by primary adenocarcinoma (ADC) of the lung. " 01/01/2023 - "Transcriptome analysis reveals the essential role of NK2 homeobox 1/thyroid transcription factor 1 (NKX2-1/TTF-1) in gastric adenocarcinoma of fundic-gland type." 04/01/2022 - "Cellblock confirmed the presence of adenocarcinoma of pulmonary origin, positive for thyroid transcription factor 1 (TTF-1). " 10/01/2021 - "IHC subcellular localization of thyroid transcription factor 1 (TTF1), in which nuclear-to-cytoplasmic translocation is known to cause a lineage shift from lung to gastric-type adenocarcinoma, was also checked. " 11/12/2019 - "In February 2017, a third lumbar vertebra biopsy showed metastatic adenocarcinoma, compatible with lung origin (thyroid transcription factor-1 positive [TTF-1], L858R mutation positive). "

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4.	Proteins (Proteins, Gene)
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6.	Thyroglobulin
7.	Mucin-1 (CA 15-3 Antigen)
8.	Messenger RNA (mRNA)
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10.	Keratins (Keratin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Micro-Electrical-Mechanical Systems
4.	Neck Dissection (Radical Neck Dissection)
5.	Adjuvant Radiotherapy