Abstract | BACKGROUND: CASE PRESENTATION: A 51-year-old female complaining of intermittent diarrhea for 2 years was admitted to our hospital. Enhancement of total abdominal computed tomography scan, echocardiography, and magnetic resonance imaging indicated a mass in the left ventricle. The indexes of myocardial enzymes were normal. Histologically, round cells with well-differentiated neuroendocrine morphology were arranged in typical pseudo-glandular, trabecular, ribbon-like, and solid nest patterns. Immunohistochemically, the tumor cells were positive for cytokeratin, chromogranin, synaptophysin, and CD56. However, they were negative for caudal type homeobox 2, S100, paired box gene 8, thyroid transcription factor 1, and CD20, which ruled out the origin of gastrointestinal, pancreatic, lung, and Merkel cell carcinomas. The symptoms of diarrhea disappeared after the operation. The patient was asymptomatic at the 9-month follow-up. CONCLUSION: Cardiac neuroendocrine tumors with diarrhea are considerably rare and related clinical research is limited. We presented a case and reviewed related articles to improve the identification, diagnosis, and management of patients with cardiac neuroendocrine tumors. The site of origin of a neuroendocrine tumor is clinically vital, and identification of an occult primary tumor using imaging modalities is necessary. Immunohistochemistry is well-suited to indicate the origin of the tumor. Regular follow-up is necessary for both poorly differentiated and well-differentiated cardiac neuroendocrine tumors. It is suggested to detect some neuroendocrinal markers for patients with unexplained reasons of diarrhea.
|
Authors | Chengfang Li, Jiajia Huang, Xiaorong Yang, Jinhua Xia, Gaoqiang Xu, Hong Zheng |
Journal | Diagnostic pathology
(Diagn Pathol)
Vol. 15
Issue 1
Pg. 32
(Apr 03 2020)
ISSN: 1746-1596 [Electronic] England |
PMID | 32245475
(Publication Type: Case Reports, Journal Article, Review)
|
Topics |
- Cardiac Surgical Procedures
(methods)
- Diarrhea
(etiology)
- Female
- Heart Neoplasms
(complications, pathology, surgery)
- Heart Ventricles
(pathology, surgery)
- Humans
- Middle Aged
- Neuroendocrine Tumors
(complications, pathology, surgery)
|