Meconium Ileus

Intestinal obstruction caused by congealed MECONIUM in the distal ILEUM and CECUM. It presents shortly after birth as a failure to pass meconium and frequently occurs in infants with CYSTIC FIBROSIS.

Also Known As:

Networked: 183 relevant articles (10 outcomes, 13 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis)
2.	Liver Diseases (Liver Disease)
3.	Exocrine Pancreatic Insufficiency
4.	Lung Diseases (Lung Disease)
5.	Pancreatic Diseases (Pancreatic Disease)

Experts

1.	Cutting, Garry R: 3 articles (01/2019 - 01/2012)
2.	Knowles, Michael R: 3 articles (01/2019 - 01/2012)
3.	Meyerholz, David K: 3 articles (06/2013 - 09/2008)
4.	Askarpour, Shahnam: 2 articles (01/2020 - 01/2020)
5.	Ayatipour, Amin: 2 articles (01/2020 - 01/2020)
6.	Javaherizadeh, Hazhir: 2 articles (01/2020 - 01/2020)
7.	Peyvasteh, Mehran: 2 articles (01/2020 - 01/2020)
8.	Blackman, Scott M: 2 articles (01/2019 - 01/2012)
9.	Keenan, Katherine: 2 articles (01/2019 - 04/2016)
10.	Lin, Fan: 2 articles (01/2019 - 01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Meconium Ileus:

1.	EnzymesIBA 01/01/2017 - "Liver enzyme elevations were not correlated with CFTR mutation, meconium ileus or ethnicity. " 04/01/2003 - "While all non-survivors had a history of meconium ileus and preoperative need of pancreatic enzymes, only 67% of those alive experienced these complications. " 01/01/1998 - "Sex, genotype, nutritional status, meconium ileus, and pancreatic enzyme supplementation were not significantly associated with pathological GOR. " 01/01/1990 - "The meconium ileus was found in 2/4 of aborted foetuses with GGT lower than 3 percentiles, abnormal activities of other microvillar enzymes and abnormal ultrasound examination. " 01/01/1990 - "From 3 pregnancies with GGT activity in the range of 3-5 percentiles and abnormal activities of other microvillar enzymes, the CF was confirmed only in one aborted foetus with meconium ileus and with abnormal ultrasound examination. "
2.	Diatrizoate Meglumine (Gastrograffin)FDA LinkGeneric 09/01/1989 - "Three neonates with meconium ileus who failed to respond to non-operative measures were successfully treated by appendicectomy and irrigation with Gastrografin into the small bowel via the appendix stump. " 11/01/1986 - "Gastrografin in acute meconium ileus equivalent." 12/01/1976 - "Possible adverse effect of methylglucamine diatrizoate compounds on the bowel of newborn infants with meconium ileus." 10/01/1987 - "Meglumine diatrizoate (Gastrografin) enema completely relieved the obstruction in 13 patients with simple meconium ileus (54%) and caused colonic and rectal perforations in three (13%). " 05/01/1993 - "Ten patients with uncomplicated meconium ileus were successfully treated with a diatrizoate meglumine (Gastrografin) enema. "
3.	Ursodeoxycholic Acid (Urso)FDA LinkGeneric 06/01/2010 - "To evaluate the effect of early treatment with ursodeoxycholic acid in patients with cystic fibrosis and meconium ileus to prevent chronic hepatic involvement and to explore the potential role of therapy on clinical outcomes. " 06/01/2010 - "Early treatment with ursodeoxycholic acid may be beneficial in patients at risk of developing cystic fibrosis chronic liver disease such as those with meconium ileus. " 06/01/2010 - "26 cystic fibrosis patients with meconium ileus (16 M, mean age 8,4 years, range 3,5-9) were assigned to two groups: group 1 (14 patients) treated early with ursodeoxycholic acid (UDCAe); group 2 (12 patients) treated with ursodeoxycholic acid at the onset of cystic fibrosis liver disease (UDCAd). " 03/01/1994 - "We conclude that patients with cystic fibrosis and meconium ileus or its equivalent may benefit from prophylactic treatment with ursodeoxycholic acid; genetic analysis of the major mutations present in this population failed to provide evidence of the existence of a specific genetic marker for the development of liver disease in patients with cystic fibrosis."
4.	DNA (Deoxyribonucleic Acid)IBA 12/01/2012 - "The IRT-DNA-IRT protocol had a much improved positive predictive value (PPV) of 85.9% compared to 67.3% for IRT-IRT, excluding CF babies with meconium ileus. " 07/01/2014 - "95 CF newborns were identified (83 classical forms (ClF), including 9 meconium ileus (MI), and 12 atypical (mild) forms (AF) Of them, IRT/DNA identified 85 (73 ClF including 5 MI and 12 AF). " 12/01/2012 - "During a 30 year period 582 966 babies have been screened by IRT-IRT and 147 764 by IRT-DNA-IRT (total 730730), resulting in 296 screen positive cases of CF and 29 false negatives (including 10 false negatives with meconium ileus). "
5.	ChloridesIBA 04/10/2012 - "The proband presented with meconium ileus and normal sweat chloride test. " 09/01/1997 - "All the studied chromosomes carrying the G85E mutation had the 7T variant in the polythymidine tract at the branch/acceptor site in intron 8. Of the G85E patients, 25% had pancreatic sufficiency and none had meconium ileus, compared with 0% and 32%, respectively, of patients from group 1, and 80% and 0%, respectively, from group 2. Two patients carrying the G85E mutation had sweat chloride levels <60 mmol/L whereas all the others had typically elevated levels >80 mmol/L. " 08/01/1992 - "A retrospective cohort analysis was performed on the following outcome parameters: age at diagnosis, sweat chloride, meconium ileus at birth, height, weight, weight for height, FVC, FEV1, chest X-ray score, pseudomonas colonization, pancreatic sufficiency, and Shwachman clinical score. " 09/01/2010 - "Neonatal CFTR-knockout ferrets demonstrated many of the characteristics of human CF disease, including defective airway chloride transport and submucosal gland fluid secretion; variably penetrant meconium ileus (MI); pancreatic, liver, and vas deferens disease; and a predisposition to lung infection in the early postnatal period. " 09/26/2008 - "Newborn pigs lacking CFTR exhibited defective chloride transport and developed meconium ileus, exocrine pancreatic destruction, and focal biliary cirrhosis, replicating abnormalities seen in newborn humans with CF. "
6.	ParaffinIBA 04/01/1995 - "Genetic studies were performed on all subjects, this study analyzes the usefulness in the detection of delta F508 mutation in formalin-fixed paraffin-embedded tissues obtained from patients with meconium ileus, ten of whom had the delta F508/delta F508 mutation." 04/01/1994 - "This study analyzes the usefulness of the polymerase chain reaction technique in the detection of delta F508 mutation in 11- to 25-yr-old formalin-fixed paraffin-embedded tissues obtained from the autopsy of 38 cystic fibrosis patients (nine with meconium ileus). "
7.	Formaldehyde (Formol)FDA Link 04/01/1995 - "Genetic studies were performed on all subjects, this study analyzes the usefulness in the detection of delta F508 mutation in formalin-fixed paraffin-embedded tissues obtained from patients with meconium ileus, ten of whom had the delta F508/delta F508 mutation." 04/01/1994 - "This study analyzes the usefulness of the polymerase chain reaction technique in the detection of delta F508 mutation in 11- to 25-yr-old formalin-fixed paraffin-embedded tissues obtained from the autopsy of 38 cystic fibrosis patients (nine with meconium ileus). "
8.	Proteins (Proteins, Gene)FDA Link 11/01/2001 - "Evaluation of the possible implication of ATB(0) in the intestinal phenotype of CF was performed on the basis of the functional characteristics of the encoded protein, its apparent relevance to meconium ileus (MI) and position in relation to the hCFM1 syntenic region. " 04/01/1968 - "Protein in meconium from meconium ileus." 03/01/1965 - "A COMPARATIVE STUDY OF THE PROTEINS IN NORMAL MECONIUM AND IN MECONIUM FROM MECONIUM ILEUS PATIENTS." 04/01/1958 - "Studies in cystic fibrosis of the pancreas; protein pattern in meconium ileus." 01/01/2012 - "Meconium ileus (MI), a life-threatening intestinal obstruction due to meconium with abnormal protein content, occurs in approximately 15 percent of neonates with cystic fibrosis (CF). "
9.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/1965 - "Two of 15 children who survived neonatal meconium ileus had "meconium ileus equivalent." They were treated with hydration, pancreatic enzyme therapy and antibiotics. " 07/01/2000 - "Recent studies have focused on the current dietary intake of cystic fibrosis patients, the impact of nutritional support on both the nutritional status and clinical outcome variables, and the effects on the nutritional status of antibiotic therapy and surgical treatment of meconium ileus. " 12/01/2011 - "Factors independently associated with liver disease at baseline were history of meconium ileus, pancreatic insufficiency, chronic colonization with Burkholderia cepacia and the number of IV antibiotic courses per year. " 09/01/1965 - "The survival rate of infants with meconium ileus is steadily improving because of prompt operative intervention, better preoperative and postoperative care and long-term treatment with enzyme supplements and antibiotics. " 01/01/2022 - "Conditional logistic regressions were adjusted for sex, lung function (FEV1%), CF related diabetes (CFRD), F508del status, transplant status, DIOS, gastro-oesophageal reflux disease, meconium ileus, Pseudomonas aeruginosa infection, pancreatic insufficiency, proton pump inhibitor (PPI) use, IV antibiotic days and BMI. "
10.	Glycoproteins (Glycoprotein)IBA 11/01/1979 - "1. The mucus glycoproteins in meconium from normal infants and from infants having cystic fibrosis with meconium ileus have been studied. " 11/01/1979 - "Study of the oligosaccharide units from mucus glycoproteins of meconium from normal infants and from cases of cystic fibrosis with meconium ileus." 12/01/1990 - "Using monoclonal antibodies, lectins, and appropriate enzymes, such as glycosyl hydrolases, it should be possible to delineate further the abnormality found in glycoproteins in cystic fibrosis on appropriately fixed ileal sections, obtained from infants at term presenting with meconium ileus."

Therapies and Procedures

1.	Enema (Enemas) 04/01/1997 - "Meconium ileus obstruction may be relieved medically by contrast enema; ileal atresia requires prompt surgical intervention. " 02/01/1970 - "Meconium ileus relieved by 40 per cent water-soluble contrast enemas." 11/01/2009 - "Contrast enema is the initial study of choice for simple meconium ileus to confirm diagnosis and to relieve obstruction. " 11/01/2009 - "The success rate in the CG group was 5.5% (1/18) compared to 39% (7/18) in HG. In this review, success of contrast enema for relief of meconium ileus has significantly decreased over time. " 11/01/2009 - "A retrospective multiinstitutional review for a 12-year period was conducted for neonates diagnosed with meconium ileus by contrast enema. "
2.	Ileostomy 07/01/2017 - "T-tube ileostomy was found as an effective and safe procedure for the management of uncomplicated meconium ileus." 07/01/2017 - "The aim of this prospective interventional study was to compare the outcome of T-tube ileostomy and Bishop Koop ileostomy for the treatment of uncomplicated meconium ileus. " 01/01/2020 - "To evaluate and compare clinical efficacy of Santulli and loop ileostomy in neonates with meconium ileus. " 01/01/2020 - "A COMPARATIVE STUDY BETWEEN SANTULLI ILEOSTOMY AND LOOP ILEOSTOMY IN NEONATES WITH MECONIUM ILEUS." 01/01/2020 - "To evaluate and compare clinical efficacy of Santulli and loop ileostomy in neonates with meconium ileus. "
3.	Therapeutics 01/01/2023 - "Only two cases of pregnant women taking CFTR modulator therapy with CF fetuses have been reported, suggesting that it could resolve meconium ileus (MI) prenatally and delay/prevent other consequences of CF. " 06/01/1997 - "The role may vary from helping to establish a diagnosis, to the evaluation of associated abnormalities, to surgical planning, or to therapy for some conditions like meconium ileus or meconium plug syndrome. " 07/01/1996 - "The role may vary from helping to establish a diagnosis, to the evaluation of associated abnormalities, to surgical planning, or to therapy for some conditions like meconium ileus or meconium plug syndrome. " 11/01/1990 - "CT monitoring of therapy for meconium ileus." 10/01/1977 - "[Current status in the diagnosis and therapy of meconium ileus]."
4.	Operative Surgical Procedures 07/01/2017 - "Various surgical procedures are in practice for uncomplicated meconium ileus. " 07/01/2006 - "Meconium ileus--is a single surgical procedure adequate?" 02/01/1992 - "These data confirm: (1) There is an improved survival for MI independent of the surgical procedure; (2) The BK ileostomy is an effective and time-tested MI treatment; (3) Primary resection and anastomosis in selected cases may have a lower surgical morbidity rate; and (4) Meconium ileus does not adversely affect the long-term nutritional outcome of CF patients." 04/01/1998 - "Long-term surgical complications (adhesive small bowel obstruction and blind loop syndrome) were seen in 27% of children with meconium ileus; there were no long-term surgical complications in groups 2 or 3, because these infants did not have any neonatal surgical procedures. "
5.	Nutritional Support (Artificial Feeding) 07/01/2000 - "Recent studies have focused on the current dietary intake of cystic fibrosis patients, the impact of nutritional support on both the nutritional status and clinical outcome variables, and the effects on the nutritional status of antibiotic therapy and surgical treatment of meconium ileus. "