Prevalence of elevated liver enzymes in children with cystic fibrosis diagnosed by newborn screen.

Abstract

BACKGROUND:

Prevalence and risks for elevated liver enzymes have not been studied systematically in children with CF identified by newborn screen.

METHODS:

298 CF children identified by newborn screen since 1982. AST, ALT and GGT tested at annual visits. Percent of children with 1 or ≥2 values of elevated AST, ALT and GGT determined. Relationship of liver enzymes to clinical factors or subsequent liver disease was analyzed RESULTS: At least one abnormal value for AST (63%), ALT (93%) and ALT ≥1.5× ULN (52%) occurred by 21years of age. Liver enzyme elevations were not correlated with CFTR mutation, meconium ileus or ethnicity. AST and GGT ≥1.5× ULN were associated with later advanced liver disease HR (CI) 6.53 (2.02-21.1) and 4.03 (1.15-13.45), respectively.

CONCLUSIONS:

Elevated liver enzymes are common during childhood in CF patients identified by newborn screen. Elevated AST and GGT may be markers for risk of advanced liver disease.

• Authors: Samantha A Woodruff, Marci K Sontag, Frank J Accurso, Ronald J Sokol, Michael R Narkewicz
• Journal: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society (J Cyst Fibros) Vol. 16 Issue 1 Pg. 139-145 (01 2017) ISSN: 1873-5010 [Electronic] Netherlands
• PMID: 27555301 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

Chemical References

• Cystic Fibrosis Transmembrane Conductance Regulator
• gamma-Glutamyltransferase
• Aspartate Aminotransferases
• Alanine Transaminase

Topics

• Adolescent
• Alanine Transaminase (blood)
• Aspartate Aminotransferases (blood)
• Child, Preschool
• Cystic Fibrosis (blood, complications, diagnosis, epidemiology)
• Cystic Fibrosis Transmembrane Conductance Regulator (genetics)
• Female
• Humans
• Infant, Newborn
• Liver Diseases (diagnosis, epidemiology, etiology)
• Liver Function Tests (methods, statistics & numerical data)
• Male
• Neonatal Screening (methods)
• Prevalence
• Prognosis
• Statistics as Topic
• United States (epidemiology)
• Young Adult
• gamma-Glutamyltransferase (blood)