F-Box-WD Repeat-Containing Protein 7

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Also Known As:

Networked: 29 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Jia, Weiqiang: 1 article (10/2021)
2.	Li, Xiaobin: 1 article (10/2021)
3.	Liu, Ning: 1 article (10/2021)
4.	Nie, Xiaohu: 1 article (10/2021)
5.	Pan, Xuyan: 1 article (10/2021)
6.	Su, Zhongzhou: 1 article (10/2021)
7.	Yin, Rui: 1 article (10/2021)
8.	Cheng, Meixiong: 1 article (03/2021)
9.	Li, Zhili: 1 article (03/2021)
10.	Wu, Yaqiu: 1 article (03/2021)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 09/01/2012 - "Fbxw7 protein was expressed at significantly lower levels in patients with high histological grade and advanced tumor-node-metastasis stage. " 01/01/2020 - "This study aims to investigate the expression levels of several genes, including metastasis-related colon cancer 1 (MACC1), Filamin A (FLNA), F-box/WD repeat-containing protein 7 (FBXW7), which has an important role in cell signaling, migration and adhesion through the remodeling of the cell skeleton. "
2.	Osteosarcoma (Osteogenic Sarcoma) 01/22/2015 - "In this study, we found that the expressions of FBXW7 protein and mRNA levels in osteosarcoma (OS) cases were significantly lower than those in normal bone tissues. "
3.	Colonic Neoplasms (Colon Cancer) 01/01/2020 - "This study aims to investigate the expression levels of several genes, including metastasis-related colon cancer 1 (MACC1), Filamin A (FLNA), F-box/WD repeat-containing protein 7 (FBXW7), which has an important role in cell signaling, migration and adhesion through the remodeling of the cell skeleton. "
4.	Hypoxia (Hypoxemia) 01/01/2020 - "The aim of the study was to observe the effect of F-box/WD repeat-containing protein 7 (FBW7) on hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) pathway in chondrocytes (CHs) under IL-1β induced degeneration. "
5.	Neoplasms (Cancer) 01/01/2023 - "The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. " 05/16/2017 - "Increased c-Myc expression was accompanied by decreased Fbxw7 protein expression in tumor tissues from mouse and patients. " 05/01/2015 - "The positive rate of FBXW7 protein was significantly lower in the ESCC and high-grade intraepithelial neoplasia tissues than in the tumor-adjacent normal tissues and low grade intraepithelial neoplasia tissues (40.0% and 33.3% vs. 85.0% and 77.3%, χ² = 21.923, P < 0.001). " 09/08/2011 - "The inverse correlation between miR-27a expression levels and Fbxw7 protein expression was further confirmed in both cell models and human tumor samples. " 09/01/2012 - "Fbxw7 protein was expressed at significantly lower levels in patients with high histological grade and advanced tumor-node-metastasis stage. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Filamins
3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Ubiquitin
5.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
6.	Oncogene Proteins (Oncogene Protein)
7.	Proteins (Proteins, Gene)
8.	Ligases (Synthetase)
9.	Ubiquitin-Specific Proteases
10.	Proto-Oncogene Proteins c-ets

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)