F-Box-WD Repeat-Containing Protein 7

A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

Also Known As:

F-Box and WD-40 Domain-Containing Protein 7; FBXW7 Protein; F Box WD Repeat Containing Protein 7; F Box and WD 40 Domain Containing Protein 7

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Ligases: 5553
    - Ubiquitin-Protein Ligase Complexes
      - Ubiquitin-Protein Ligases: 3432
        SKP Cullin F-Box Protein Ligases: 36
        F-Box-WD Repeat-Containing Protein 7: 29
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - F-Box Proteins: 328
      - F-Box-WD Repeat-Containing Protein 7: 29
  - Cell Cycle Proteins: 807
    - F-Box-WD Repeat-Containing Protein 7: 29

Xenopus Fbxw7 protein

Bio-Agent Context: Research Results