PAX8 Transcription Factor

A paired box transcription factor that functions in the development of THYROCYTES and the control of thyroid-specific gene expression. Mutations in the PAX8 gene are associated with THYROID DYSGENESIS and THYROID NEOPLASMS.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Drapkin, Ronny: 2 articles (01/2022 - 05/2010)
2.	Dundjerovic, Dusko: 1 article (08/2022)
3.	Ivanov, Milan: 1 article (08/2022)
4.	Karanovic, Danijela: 1 article (08/2022)
5.	Kovacevic, Sanjin: 1 article (08/2022)
6.	Markovic-Lipkovski, Jasmina: 1 article (08/2022)
7.	Naumovic, Radomir: 1 article (08/2022)
8.	Nesovic Ostojic, Jelena: 1 article (08/2022)
9.	Nikolic, Gorana: 1 article (08/2022)
10.	Radojevic Skodric, Sanja: 1 article (08/2022)

Related Diseases

1.	Follicular Adenocarcinoma 10/01/2012 - "The fusion gene encoding the thyroid-specific transcription factor PAX8 and peroxisome proliferator-activated receptor γ (PPARγ (PPARG)) (designated as the PPFP gene) is oncogenic and implicated in the development of follicular thyroid carcinoma (FTC). " 01/01/2003 - "A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma). "
2.	Genetic Translocation (Chromosomal Translocation) 10/01/2005 - "A chromosomal translocation between the transcription factor PAX8 and the peroxisome proliferator-activated receptorgamma (PPARgamma) occurs in 30-50% of patients; however, the presence of PAX8-PPARgamma is also demonstrated in follicular adenomas. " 01/01/2003 - "A recent study of follicular thyroid carcinomas reported a novel chromosomal translocation, t(2;3)(q13;p25), that fused the thyroid-specific transcription factor PAX8 with a nuclear receptor, peroxisome proliferator-activated receptor gamma (PPAR gamma). "
3.	Neoplasms (Cancer) 08/23/2022 - "Transcription factor PAX8, expressed during embryonic kidney development, has been previously detected in various kidney tumors. " 10/01/2019 - "Transcription factor PAX8 expression is upregulated in several types of cancers. " 03/01/2017 - "Immunohistochemistry for transcription factor PAX8 (paired box gene 8) has recently emerged as a powerful tool in the differential diagnosis of gynecologic malignancies, especially when encountered at a metastatic site. " 05/01/2010 - "Recently, transcription factor PAX8 was shown to be a sensitive and relatively specific marker for Müllerian tumors. " 07/01/2016 - "The transcription factor PAX8, a member of the paired box-containing gene family with an important role in embryogenesis of the kidney, thyroid gland and nervous system, has been described as a biomarker in tumors of the thyroid, parathyroid, kidney and thymus. "
4.	Congenital Hypothyroidism (Cretinism) 01/01/2019 - "Thyroid-specific transcription factor PAX8 has an indispensable role in the thyroid gland development, which is evidenced by the facts that PAX8/Pax8 mutations cause congenital hypothyroidism in humans and mice. " 07/01/2005 - "Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. " 08/01/2001 - "Congenital hypothyroidism associated with thyroid hypoplasia can be caused by several genetic defects, including mutations in the TSHbeta-subunit, the TSH receptor, the G(s)alpha-subunit, and the transcription factor PAX8. "
5.	Thyroid Dysgenesis (Thyroid Agenesis) 07/01/2005 - "Mutations in the paired domain transcription factor PAX8 are a rare cause of congenital hypothyroidism due to thyroid dysgenesis. " 08/01/2001 - "Congenital hypothyroidism associated with thyroid hypoplasia can be caused by several genetic defects, including mutations in the TSHbeta-subunit, the TSH receptor, the G(s)alpha-subunit, and the transcription factor PAX8. "

Related Drugs and Biologics

1.	PPAR gamma
2.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
3.	Peroxisome Proliferator-Activated Receptors (PPAR)
4.	Biomarkers (Surrogate Marker)
5.	Protein Isoforms (Isoforms)
6.	Gs GTP-Binding Protein alpha Subunits (G(s)alpha)
7.	Thyrotropin Receptors (Thyrotropin Receptor)
8.	Proteins (Proteins, Gene)
9.	DNA (Deoxyribonucleic Acid)
10.	Racivir