Oxysterols

01/01/2016 - " two methods are also suitable to study strategies to block oxysterol release by tumor cells. "
08/26/2013 - "New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic neutrophils into the tumor microenvironment. "
03/09/2011 - "Numerous studies show that oxysterols are associated with various types of cancer, including cancers of the colon, lung, skin, breast and bile ducts. "
03/01/1989 - "Studies of the oxysterol inhibition of tumor cell growth."
08/01/2022 - "Oxysterol metabolism plays an important role in the initiation and development of various tumors. "

10/01/2014 - "Our recent studies show that, in cells of the macrophage lineage or in human neuronal cells (differentiated or not), respectively in the contest of atherosclerosis or AD, oxysterols can initiate specific signal transduction pathways that are relevant to the development of these diseases. "
01/01/2024 - "Oxysterols in Vascular Cells and Role in Atherosclerosis."
07/01/2022 - "To determine the relationship between multiple oxysterol molecules and atherosclerosis burden in MS patients. "
01/01/2021 - "Oxidized LDLs (oxLDLs) and oxysterols play a key role in endothelial dysfunction and the development of atherosclerosis. "
10/02/2017 - "Current knowledge on the mechanism of atherosclerosis and pro-atherosclerotic properties of oxysterols."

01/01/2022 - "7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome."
02/26/2021 - "Transcriptomic Changes Associated with Loss of Cell Viability Induced by Oxysterol Treatment of a Retinal Photoreceptor-Derived Cell Line: An In Vitro Model of Smith-Lemli-Opitz Syndrome."
11/01/2020 - "Furthermore, CAR elevated toxic oxysterols in the brain of maternally exposed Dhcr7+/- offspring to levels approaching those seen in a mouse model of Smith-Lemli-Opitz syndrome. "
01/01/2015 - "The metabolism of these oxysterols in cells and the biological consequences of their formation will be discussed in the context of the pathophysiology of the human disease Smith-Lemli-Opitz syndrome. "
10/01/2011 - "Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome."

02/01/2023 - "Oxysterols were quantified for the first time in allergic asthma. "
02/01/2023 - "Oxysterols were quantified by LC-MS/MS in plasma samples of 120 asthma patients (90 females + 30 males) and 120 healthy controls (matched by age and sex). "
02/01/2023 - "Since the high plasma 7-KC and C-triol levels of allergic asthma patients correlate with high IgE levels, detection of these oxysterols by LC-MS/MS may be helpful in the clinical monitoring of allergic asthma. "
02/01/2023 - "Plasma levels of oxysterols 7-ketocholesterol and cholestane-3β, 5α, 6β-triol in patients with allergic asthma."
01/01/2017 - "To determine whether oxysterol ligands for EBI2 are increased in asthma exacerbation, and if or how they promote Eos pulmonary migration. "

01/01/2023 - "This argues for a functional role of the oxysterol pathway and its products as an important mediator in the pathogenesis of human cataracts."
05/01/1998 - "We have shown, for the first time, that oxysterols accumulate in human cataracts. "
01/01/2022 - "To investigate how cataract-linked mutations affect the gradient refractive index (GRIN) and lens opacification in mouse lenses and whether there is any effect on the optics of the lens from treatment with an oxysterol compound. "
01/01/2023 - "Antioxidants and oxysterols have been shown to improve or reverse lens opacity in cataract models. "
11/01/2019 - "Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts."