AC133 Antigen

A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.

Also Known As:

Networked: 187 relevant articles (2 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Corbeil, Denis: 14 articles (12/2017 - 03/2003)
2.	Huttner, Wieland B: 8 articles (01/2014 - 03/2003)
3.	Fargeas, Christine A: 7 articles (01/2014 - 03/2003)
4.	Mavila, Nirmala: 4 articles (01/2019 - 09/2014)
5.	Nguyen, Marie V: 4 articles (01/2019 - 09/2014)
6.	Wang, Kasper S: 4 articles (01/2019 - 09/2014)
7.	Karbanová, Jana: 4 articles (12/2017 - 02/2011)
8.	Janich, Peggy: 4 articles (01/2014 - 04/2007)
9.	Marzesco, Anne-Marie: 4 articles (01/2014 - 01/2005)
10.	Lorico, Aurelio: 4 articles (06/2013 - 12/2008)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/2021 - "Prominin-1 (CD133) is one of the most well-characterized markers of CSCs in various tumor types, including hepatocellular carcinoma (HCC). " 08/01/2010 - "CD133 antigen has been used to identify cancer stem cells in several solid tumor types, including hepatocellular carcinomas (HCCs). " 01/01/2013 - "CD133/prominin-1-mediated autophagy and glucose uptake beneficial for hepatoma cell survival." 11/01/2017 - "CD133 antigen is a transmembrane glycoprotein and regarded as a cancer stem cells marker in hepatocellular carcinoma. " 11/10/2020 - "Prominin 1 (PROM1) is one of a few clinically relevant progenitor markers in human alcoholic hepatitis (AH) and hepatocellular carcinoma (HCC), and mouse liver tumor initiating stem cell-like cells (TICs). "
2.	Adenocarcinoma of Lung 06/01/2012 - "High expression of octamer-binding transcription factor 4A, prominin-1 and aldehyde dehydrogenase strongly indicates involvement in the initiation of lung adenocarcinoma resulting in shorter disease-free intervals."
3.	Neoplasms (Cancer) 10/17/2023 - "CD133 (prominin 1) is widely viewed as a cancer stem cell marker in association with drug resistance and cancer recurrence. " 01/01/2023 - "CD133, also called prominin-1, is widely known as a cancer stem cell marker, and its high expression correlates with a poor prognosis in many cancers. " 11/08/2021 - "</br></br> <b> Results:</b> Statistically significant prominin-1 expression was detected in cases with dysplasia and malignancy. " 01/01/2021 - "In cancer cells, miR-34a overexpression downregulated prominin 1, while miR-34a knockdown upregulated prominin 1. Moreover, miR-34a overexpression reduced the enchaining effects of prominin 1 on LC cell proliferation. " 01/01/2021 - "In addition, prominin 1 and miR-34a were inversely correlated across cancer tissue samples. "
4.	Lung Neoplasms (Lung Cancer) 01/01/2014 - "The electronic and manual searches were performed through the database of Pubmed, Medline, Web of Science, Scopus, and Chinese CNKI (from January 1, 1982 to January 1, 2014) for titles and abstracts by using the following keywords: "CD133", "ac133" or "Prominin-1", and "lung cancer" to identify the studies eligible for our analysis. " 07/01/2011 - "The objective of the current study was to investigate the effect of the strong STAT3 inhibitor, cucurbitacin I, in prominin-1 (CD133)-positive lung cancer cells. " 09/10/2013 - "The stem cell-like resistance to injury and proliferative potentials of bronchioalveolar stem cells (BASCs) and alveolar epithelial type II cells (AEC2), as well as cells that express the cancer stem cell marker glycoprotein prominin-1 (CD133) or markers for side populations make them potential reservoirs of lung cancer stem cells. " 01/31/2014 - "This study investigated gene mutations in a Han Chinese family of lung cancer using the whole genome exome sequencing and subsequent Sanger sequencing validation and then confirmed alteration of prominin 1(PROM1) and cyclic AMP-response element binding protein-regulated transcription co-activator2 (CRTC2) in blood samples of 343 sporadic lung cancer patients vs. 280 healthy controls as well as in 200 pairs of lung cancer and the corresponding normal tissues using PCR-restriction fragment length polymorphism and directed DNA sequencing of PCR products. "
5.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2014 - "In this study, CSCs were isolated from colorectal cancer cells using PROM1/CD133 (prominin 1) expression, which is a surface marker commonly found on stem cells of various tissues. " 09/01/2016 - "In colorectal cancer, the CD133 antigen defines distinct cell subpopulations that are rich in tumor-initiating cells; however, the drug resistance properties of these CD133-positive cells have not been well defined. " 07/01/2012 - "The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues. " 07/01/2012 - "Our observations indicate that the presence of the CD133 antigen does not identify a stem cell population of SW620 colorectal cancer cells. " 01/01/2010 - "O'Brien and Ricci et al. have proved that in primary colorectal tumors there are colorectal tumor stem cells (initiating cells) which are marked by CD133 antigen. "

Related Drugs and Biologics

1.	Transcription Factors (Transcription Factor)
2.	Glucose (Dextrose)
3.	Aldehyde Dehydrogenase
4.	Proteins (Proteins, Gene)
5.	AC133 Antigen
6.	Biomarkers (Surrogate Marker)
7.	Nestin
8.	Epithelial Cell Adhesion Molecule
9.	Osteopontin
10.	Vascular Endothelial Growth Factor Receptor-3 (Flt 4)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chemoradiotherapy
4.	Radiotherapy
5.	Injections