Glycodelin

A lipocalin that is the most abundant protein synthesized and secreted by the ENDOMETRIUM from mid-LUTEAL PHASE of the MENSTRUAL CYCLE through early PREGNANCY.

Also Known As:

Pregnancy-Associated Endometrial Alpha-2 Globulin; Progestagen-Associated Endometrial Protein; Endometrial Protein, Progestagen-Associated; Pregnancy Associated Endometrial Alpha 2 Globulin; Progestagen Associated Endometrial Protein

Networked: 125 relevant articles (1 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jeschke, Udo: 17 articles (01/2021 - 03/2005)
2.	Koistinen, Riitta: 17 articles (10/2016 - 01/2002)
3.	Friese, Klaus: 14 articles (03/2014 - 03/2005)
4.	Koistinen, Hannu: 12 articles (01/2020 - 08/2002)
5.	Seppälä, Markku: 9 articles (03/2011 - 01/2002)
6.	Mylonas, Ioannis: 9 articles (05/2010 - 03/2005)
7.	Yeung, William S B: 7 articles (01/2020 - 01/2007)
8.	Chiu, Philip C N: 6 articles (01/2020 - 01/2007)
9.	Kunert-Keil, Christiane: 6 articles (12/2013 - 03/2005)
10.	Scholz, Christoph: 6 articles (10/2012 - 01/2009)

Related Diseases

1.	Atrophy 08/01/2003 - "Data on PP-14 (glycodelin) levels may indicate that E2V/DNG is even more effective than E2/NETA in maintaining endometrial atrophy. "
2.	Endometriosis 05/01/2013 - "The aim of this study was to evaluate serum and peritoneal fluid (PF) glycodelin-A concentrations in women with ovarian endometriosis. " 05/01/2013 - "Endometriosis patients had significantly higher serum and PF glycodelin-A concentrations compared to controls, and this increase was observed in both proliferative and secretory cycle phases. " 05/01/2013 - "Elevated glycodelin-A concentrations in serum and peritoneal fluid of women with ovarian endometriosis." 05/01/2009 - "To analyze the expression of the glycodelin gene to better understand the molecular environment of endometriotic lesions and to elucidate the potential mechanisms that underlie the complex physiopathology of endometriosis. " 05/01/2009 - "Glycodelin expression in the endometrium of healthy women and in the eutopic and ectopic endometrium of women with endometriosis."
3.	Carcinoma (Carcinomatosis) 05/01/2010 - "Determination of glycodelin-A expression correlated to grading and staging in ovarian carcinoma tissue." 05/01/2005 - "Glycodelin is expressed in normal glandular epithelium of the endometrium as well as in endometrial, ovarian and cervical carcinoma cells. " 03/01/2005 - "Glycodelin, previously known as PP14, has been localized in endometrial, ovarian and cervical carcinoma cells. " 10/01/2003 - "It is concluded that, in ovarian serous carcinoma, glycodelin expression portends better prognosis, probably because of its differentiation-related disposition." 10/01/2003 - "Glycodelin expression was more frequent in well-differentiated (grade I, 79%) than in poorly differentiated carcinomas (grade III, 51%; P < 0.0001), and it was also more frequent in early-stage compared with advanced-stage carcinomas (P = 0.002). "
4.	Neoplasms (Cancer) 05/01/2010 - "The aim of this study was to assess the expression of glycodelin in malignant tumors of the ovary correlated to grading and staging. " 05/01/2005 - "The role of glycodelin in human reproduction and gynecological malignancies has been investigated in a large number of studies in recent years. " 11/01/2019 - "Glycodelin or PAEP, the serum levels of which are known to be elevated in lung and other cancers, served as a benchmark for comparison. " 01/01/2017 - "Glycodelin possesses the abilities to regulate cancer cell proliferation, differentiation, and invasion, promote cancer angiogenesis, and modulate the differentiation and function of immune cells including T cells, dendritic cells, monocyte-macrophages, natural killer cells and B cells participating in cancer development. " 01/01/2017 - "This review focuses on the expression of glycodelin in different cancers and its role in cancer development and progression. "
5.	Flushing 05/01/2011 - "At day LH+1, glycodelin concentration is increased in endometrial flushing fluid from infertile women with abnormal tubes compared to fertile controls without being a valuable predictor of subsequent pregnancy. " 05/01/2011 - "At day LH+7, glycodelin levels in endometrial flushing fluids and biopsies depended on endometrial dating. " 05/01/2011 - "Glycodelin levels in endometrial flushing fluids (EFF), biopsies, and plasma samples were related to tubal pathology, endometrial dating and IVF outcome. " 05/01/2011 - "Glycodelin in endometrial flushing fluid and endometrial biopsies from infertile and fertile women." 12/01/2010 - "Glycodelin in serum and uterine flushings was significantly elevated in the periovulatory phase when compared to control cycles. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Pregnancy-Associated Plasma Protein-A (PAPP-A)
3.	Insulin-Like Peptides
4.	Protein Isoforms (Isoforms)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Osteoprotegerin
7.	Interleukin-8 (Interleukin 8)
8.	Biomarkers (Surrogate Marker)
9.	Messenger RNA (mRNA)
10.	Progesterone

Related Therapies and Procedures

1.	Therapeutics
2.	Uterine Myomectomy
3.	Postcoital Contraception (Emergency Contraception)
4.	Ligation
5.	Immunotherapy