ORAI1 Protein

The pore-forming subunit of calcium release activated calcium channels. It is activated by STROMAL INTERACTION MOLECULE 1 upon intracellular calcium depletion.

Also Known As:

Calcium Release-Activated Calcium Channel Protein 1; ORAI Calcium Release-Activated Calcium Modulator 1; Calcium Release Activated Calcium Channel Protein 1; ORAI Calcium Release Activated Calcium Modulator 1

Networked: 23 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120
        ORAI1 Protein: 23
        C elegans ORAI-1 protein
        Drosophila olf186-F protein
        human ORAI1 protein
        mouse Orai1 protein
        rat Orai1 protein
        Xenopus ORAI1 protein
        zebrafish orai1b protein
  - Membrane Proteins: 10078
    - Membrane Glycoproteins: 2252
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120
        ORAI1 Protein: 23
        C elegans ORAI-1 protein
        Drosophila olf186-F protein
        human ORAI1 protein
        mouse Orai1 protein
        rat Orai1 protein
        Xenopus ORAI1 protein
        zebrafish orai1b protein
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Calcium Channels: 3471
        Calcium Release Activated Calcium Channels: 120
        ORAI1 Protein: 23
        C elegans ORAI-1 protein
        Drosophila olf186-F protein
        human ORAI1 protein
        mouse Orai1 protein
        rat Orai1 protein
        Xenopus ORAI1 protein
        zebrafish orai1b protein

Experts

1.	Li, Ming: 3 articles (04/2022 - 12/2020)
2.	Loor, Juan J: 3 articles (04/2022 - 12/2020)
3.	Xu, Chuang: 3 articles (04/2022 - 12/2020)
4.	Yang, Wei: 3 articles (04/2022 - 12/2020)
5.	Zhang, Bingbing: 3 articles (04/2022 - 12/2020)
6.	Guo, Han: 2 articles (04/2022 - 12/2020)
7.	Ma, Xinru: 2 articles (04/2022 - 12/2020)
8.	Wang, Jingjing: 2 articles (04/2022 - 07/2021)
9.	Wen, Jianan: 2 articles (04/2022 - 07/2021)
10.	Wang, Shuang: 2 articles (07/2021 - 12/2020)

Related Diseases

1.	Inflammation (Inflammations) 12/01/2022 - "STIM1(Stromol interaction molecule 1)/ORAI1 (Orai calcium release-activated calcium modulator 1) is an important inflammatory receptor, participating in the regulation of intracellular calcium signals by inflammation. " 04/01/2022 - "Therefore, the purpose of this research was to evaluate the effect of high-concentrate feeding on STIM1 (stromal interaction molecule 1)/ORAI1 (Orai calcium release-activated calcium modulator 1)-mediated inflammation, endoplasmic reticulum stress (ERS), and apoptosis in the mammary tissue of dairy cows. " 01/01/2021 - "To explore the role of STIM1-gated SOCE in vascular endothelial cell calcium overload and inflammation, we established a human septic serum or lipopolysaccharide (LPS)-induced human umbilical vein endothelial cell (HUVEC) experimental system and derived ribonucleic acid interference (RNAi)-mediated STIM1, ORAI1 (orai gene [HGNC: 25896 Entrez Gene: 84876] coding protein, ORAI Calcium Release-Activated Calcium Modulator 1), and transient receptor potential channel 1 (TRPC1) (core components of store-operated Ca2+[SOC]) downregulated HUVECs, as well as STIM1 overinduced HUVECs. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2012 - "We have previously shown that the downregulation of Orai1 protein representing the major molecular component of endogenous SOCE in human prostate cancer cells, and constituting the principal source of Ca(2+) influx used by the cell to trigger apoptosis, contributes to the establishment of an apoptosis-resistant phenotype (Cell Death Dis. " 09/16/2010 - "Here, we show that the recently identified Orai1 protein represents the major molecular component of endogenous store-operated Ca(2+) entry (SOCE) in human prostate cancer (PCa) cells, and constitutes the principal source of Ca(2+) influx used by the cell to trigger apoptosis. "
3.	Breast Neoplasms (Breast Cancer) 05/24/2022 - "Using CRISPR-Cas9 gene editing, ORAI1 protein expression was disrupted in MDA-MB-231 and MDA-MB-468 basal breast cancer cells. " 01/01/2015 - "The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. "
4.	Triple Negative Breast Neoplasms 10/15/2020 - "Here, we found a new P4-dependent Ca2+ mobilization pathway in MDA-MB-231 cells and other triple-negative breast cancer cells, as well as in MCF7 cells that involved Stromal interaction molecule 2 (STIM2), Calcium release-activated calcium channel protein 1 (Orai1), and Transient Receptor Potential Channel 1 (TRPC1). "
5.	Chronic Obstructive Pulmonary Disease (COPD) 04/01/2022 - "The abnormal polarization of the neutrophils from the COPD patients was altered by the influence of store-operated calcium entry (SOCE) component matrix interaction molecules 1 and 2 and calcium release-activated calcium channel protein 1 [stromal interaction molecule 1 (STIM1), Stromal interaction molecule 2 (STIM2), and calcium release-activated calcium modulator 1 (ORAI1)]. "

Related Drugs and Biologics

1.	Stromal Interaction Molecule 1
2.	Proteins (Proteins, Gene)
3.	Calcium
4.	Transient Receptor Potential Channels
5.	Stromal Interaction Molecule 2
6.	Sarcoplasmic Reticulum Calcium-Transporting ATPases
7.	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)
8.	Calcineurin
9.	Thapsigargin
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Lasers (Laser)