The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese.

Abstract

The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed low values of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

• Authors: Fu Ou-Yang, Yu-Da Lin, Li-Yeh Chuang, Hsueh-Wei Chang, Cheng-Hong Yang, Ming-Feng Hou
• Journal: BioMed research international (Biomed Res Int) Vol. 2015 Pg. 281263 ( 2015) ISSN: 2314-6141 [Electronic] United States
• PMID: 26380267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channels
• ORAI1 Protein
• ORAI1 protein, human

Topics

• Algorithms
• Breast Neoplasms (epidemiology, genetics)
• Calcium Channels (genetics)
• Case-Control Studies
• Computational Biology (methods)
• Databases, Genetic
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• ORAI1 Protein
• Polymorphism, Single Nucleotide (genetics)
• Risk
• Taiwan (epidemiology)