Calcium Release Activated Calcium Channels

Specialized calcium channels that localize to the ENDOPLAMSIC RETICULUM and PLASMA MEMBRANE. They contain the pore subunit ORAI1 PROTEIN which is activated by STROMAL INTERACTION MOLECULES upon intracellular calcium depletion.

Also Known As:

Networked: 120 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Feske, Stefan: 16 articles (10/2020 - 05/2006)
2.	Shuttleworth, Trevor J: 12 articles (01/2018 - 08/2007)
3.	Thompson, Jill L: 9 articles (01/2018 - 08/2007)
4.	Prakriya, Murali: 7 articles (01/2019 - 05/2006)
5.	Vaeth, Martin: 6 articles (10/2020 - 10/2014)
6.	Mignen, Olivier: 6 articles (01/2013 - 08/2007)
7.	Parekh, Anant B: 5 articles (05/2012 - 03/2009)
8.	Hebbar, Sudarshan: 4 articles (01/2022 - 01/2019)
9.	Liu, Shuang: 4 articles (04/2018 - 10/2014)
10.	Maeyama, Kazutaka: 4 articles (04/2018 - 10/2014)

Related Diseases

1.	Pneumonia (Pneumonitis) 01/01/2020 - "This study aimed to investigate the safety and efficacy of Auxora, a novel, intravenously administered CRAC channel inhibitor, in adults with severe or critical COVID-19 pneumonia. " 01/01/2022 - "CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in adults with severe COVID-19 pneumonia. " 01/01/2022 - "Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. "
2.	COVID-19 01/01/2020 - "This study aimed to investigate the safety and efficacy of Auxora, a novel, intravenously administered CRAC channel inhibitor, in adults with severe or critical COVID-19 pneumonia. " 01/01/2020 - "Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. " 01/01/2022 - "CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in adults with severe COVID-19 pneumonia. " 01/01/2022 - "Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. "
3.	Asthma (Bronchial Asthma) 02/01/2011 - "Drugs that inhibit CRAC channels are proving effective in treatment of allergic responses both in vitro and in animal models of asthma. " 12/01/2015 - "In conclusion, our data provides evidence that suggests targeting CRAC channels could be of therapeutic benefit for asthma sufferers. " 12/01/2015 - "The role of CRAC channel in asthma." 04/01/2015 - "The major role of the respiratory epithelium in asthma pathogenesis was highlighted only recently and CRAC channels were proposed as the most significant route of Ca2+ entry into epithelial cells. " 04/01/2015 - "The effect of long-term administered CRAC channels blocker on the functions of respiratory epithelium in guinea pig allergic asthma model."
4.	Pancreatitis 01/15/2016 - "CRAC channel inhibitors, which have been shown to protect PACs against damage caused by agents inducing pancreatitis, therefore also inhibit Ca(2+) signal generation in PSCs and this may be helpful in treating acute pancreatitis." 01/01/2021 - "Auxora for the Treatment of Patients With Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome: Clinical Development of a Calcium Release-Activated Calcium Channel Inhibitor."
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/01/2014 - "In vivo administration of CRAC channel blockers effectively reduced the severity of experimental autoimmune encephalomyelitis by suppression of differentiation of inflammatory T cells. "

Related Drugs and Biologics

1.	zegocractin
2.	Calcium Release Activated Calcium Channels
3.	Proteins (Proteins, Gene)
4.	Adrenal Cortex Hormones (Corticosteroids)
5.	4- methyl- 4'- (3,5- bis(trifluoromethyl)- 1H- pyrazol- 1- yl)- 1,2,3- thiadiazole- 5- carboxanilide
6.	Staphylococcal Protein A (Protein A)
7.	RP3128
8.	Calcium
9.	Arachidonic Acid (Vitamin F)
10.	Cytokines

Related Therapies and Procedures

1.	Therapeutics