Protein Phosphatase 2C

One of four major classes of mammalian serine/threonine specific protein phosphatases. Protein phosphatase 2C is a monomeric enzyme about 42 kDa in size. It shows broad substrate specificity dependent on divalent cations (mainly manganese and magnesium). Three isozymes are known in mammals: PP2C -alpha, -beta and -gamma. In yeast, there are four PP2C homologues: phosphatase PTC1 that have weak tyrosine phosphatase activity, phosphatase PTC2, phosphatase PTC3, and PTC4. Isozymes of PP2C also occur in Arabidopsis thaliana where the kinase-associated protein phosphatase (KAPP) containing a C-terminal PP2C domain, dephosphorylates Ser/Thr receptor-like kinase RLK5.

Also Known As:

Magnesium-Dependent Protein Phosphatase 2C beta; PP2C beta; PP2Cepsilon; PP2Cgamma; PPM1 Magnesium-Dependent Protein Phosphatases; PPM1 Protein Phosphatases; PPM1D Phosphatase; PPM1E Phosphatase; PPM1G Phosphatase; Ppm1b Phosphatase; Protein Phosphatase 1D Magnesium-Dependent, delta isoform; Protein Phosphatase 2C beta; Protein Phosphatase 2C delta; Protein Phosphatase 2C epsilon; Protein Phosphatase 2C gamma; Ptc2 Phosphatase; 2C, Protein Phosphatase; Magnesium Dependent Protein Phosphatase 2C beta; PPM1 Magnesium Dependent Protein Phosphatases; Phosphatase 2C, Protein; Phosphatase, PPM1D; Phosphatase, PPM1E; Phosphatase, PPM1G; Phosphatase, Ppm1b; Phosphatase, Ptc2; Phosphatases, PPM1 Protein; Protein Phosphatase 1D Magnesium Dependent, delta isoform; Protein Phosphatases, PPM1; beta, PP2C

Networked: 37 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chuman, Yoshiro: 3 articles (10/2015 - 09/2011)
2.	Sakaguchi, Kazuyasu: 3 articles (10/2015 - 09/2011)
3.	Cao, Wei: 2 articles (05/2020 - 10/2019)
4.	Hao, Qiongyu: 2 articles (05/2020 - 10/2019)
5.	Li, Jieqing: 2 articles (05/2020 - 10/2019)
6.	Vadgama, Jay: 2 articles (05/2020 - 10/2019)
7.	Wu, Yong: 2 articles (05/2020 - 10/2019)
8.	Tanino, Keiji: 2 articles (10/2015 - 01/2012)
9.	Yoshimura, Fumihiko: 2 articles (10/2015 - 01/2012)
10.	Noguchi, Yoshie: 2 articles (06/2009 - 02/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2011 - "These results suggested that this method should be very useful for the PPM1D phosphatase assay, including high-throughput analysis and screening of specific inhibitors as anti-cancer drugs. " 01/01/2021 - "Inhibition of the DNA damage response phosphatase PPM1D reprograms neutrophils to enhance anti-tumor immune responses." 10/01/2015 - "Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation." 10/01/2019 - "Although nuclear type 2C protein phosphatase (PP2Cδ) has been demonstrated to be pro-oncogenic with an important role in tumorigenesis, the underlying mechanisms that link aberrant PP2Cδ levels with cancer development remain elusive. " 11/26/2015 - "PPM1D phosphatase, also called wild-type p53-induced phosphatase 1, promotes tumor development by inactivating the p53 tumor suppressor pathway. "
2.	Stomach Neoplasms (Stomach Cancer) 05/09/2017 - "AMPKα phosphatase Ppm1E upregulation in human gastric cancer is required for cell proliferation." 05/09/2017 - "In the current study, we tested expression and potential function of Ca2+/calmodulin-dependent protein kinase phosphatase (Ppm1E), an AMPKα phosphatase, in human gastric cancers. "
3.	Meningioma (Meningiomas) 07/01/2016 - "The aim of our study was to clarify the expression and gene copy number levels of protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), which is thought to be a regulator of the p53 protein in meningiomas of all three different WHO grades. "
4.	Disease Resistance 03/01/2022 - "In addition, we found that type 2C protein phosphatase 1 (MePP2C1) interacted with MeASMT2 to interfere with MePR1-MeASMT2 interaction, so as to inhibiting the effect of MeASMT2 and MePR1 on positively regulating cassava disease resistance. " 06/01/2009 - "Ectopic expression of a rice protein phosphatase 2C gene OsBIPP2C2 in tobacco improves disease resistance." 04/01/2023 - "Furthermore, protein phosphatase 2C 12 (MePP2C12) interacted with MeHDA9 in vivo and in vitro, and it was involved in MeHDA9-mediated disease resistance via melatonin biosynthetic pathway. " 01/01/2009 - "Four of these (a remorin, a protein phosphatase 2C (PP2C), an RNA-binding protein, and a C2-domain-containing protein) are potentially early signaling components in the interaction between AvrRpm1 and the cognate disease resistance gene product, resistance to Pseudomonas syringae pv. maculicola 1 (RPM1). " 01/01/2020 - "Several proteins were predicted as the key hub node, including Hsp70, DEAD/DEAH box RNA helicase PRH75, elongation factor EF-2, cell division cycle 5, ARF guanine-nucleotide exchange factor GNOM-like, and protein phosphatase 2C 70 protein, which interacted with several disease resistance proteins such as RLP37, RPP13 and RPS2 analogues. "
5.	Dehydration (Water Stress) 02/01/2012 - "An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves." 12/01/2009 - "Almost all dehydration-responsive LEA (late embryogenesis abundant) protein genes and group-A PP2C (protein phosphatase 2C) genes are strongly down-regulated in the srk2d/e/i triple mutants. " 12/01/2014 - "Natural regeneration from these stands was transferred to a common garden and used to investigate the expression of genes for abscisic acid (ABA)-related drought signaling [9-cis-epoxy-dioxygenase (NCED), protein phosphatase 2C (PP2C), early responsive to dehydration (ERD)] and stress protection [ascorbate peroxidase (APX), superoxide dismutase (SOD), aldehyde dehydrogenase (ALDH), glutamine amidotransferase (GAT)] that are involved in drought acclimation. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Phosphoric Monoester Hydrolases (Phosphatases)
3.	Calcium-Calmodulin-Dependent Protein Kinases
4.	Phosphoprotein Phosphatases (Phosphatases, Protein)
5.	Abscisic Acid
6.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
7.	Threonine (L-Threonine)
8.	Serine (L-Serine)
9.	Metals
10.	Ascorbate Peroxidases