beta-Arrestin 2

A beta-arrestin that functions similarly to BETA-ARRESTIN 1 in regulating signaling by G-PROTEIN-COUPLED RECEPTORS. It is expressed at high levels in the central nervous system where it may regulate signaling by SYNAPTIC RECEPTORS.

Also Known As:

Networked: 30 relevant articles (0 outcomes, 7 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Halushka, Perry V: 3 articles (07/2010 - 01/2008)
2.	Beaulieu, Jean-Martin: 3 articles (01/2009 - 07/2005)
3.	Caron, Marc G: 3 articles (01/2009 - 07/2005)
4.	Gainetdinov, Raul R: 3 articles (01/2009 - 07/2005)
5.	Cook, James A: 2 articles (07/2010 - 01/2008)
6.	Fan, Hongkuan: 2 articles (07/2010 - 01/2008)
7.	Zingarelli, Basilia: 2 articles (07/2010 - 01/2008)
8.	Lefkowitz, Robert J: 2 articles (01/2008 - 07/2005)
9.	Marion, Sébastien: 2 articles (01/2008 - 07/2005)
10.	Sotnikova, Tatyana D: 2 articles (01/2008 - 07/2005)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "In this study, structural and dynamical properties of one of β -arrestin2 (arrestin 3) variants, A248T, which has been identified in some cancer tissue samples, were investigated via molecular dynamics simulations. " 02/21/2003 - "Oncoprotein Mdm2 is a master negative regulator of the tumor suppressor p53 and has been recently shown to regulate the ubiquitination of beta-arrestin 2, an important adapter and scaffold in signaling of G-protein-coupled receptors (GPCRs). " 06/01/2008 - "Furthermore, TP-beta mediated multiple biological effects by signaling through either G-protein alpha subunit 12 or beta-arrestin 2. Treatment of mice with the TP receptor antagonist GR32191, alone or in combination with cisplatin, significantly delayed tumor onset and prolonged survival of mice transplanted with TCC-SUP bladder cancer cells compared with vehicle or cisplatin alone. "
2.	Sepsis (Septicemia) 01/01/2008 - "These studies demonstrate that beta-arrestin 2 is a negative regulator of PMN activation and pulmomary leukosequestration in response to polymicrobial sepsis." 07/01/2010 - "Our data demonstrate that beta-arrestin 2 functions to negatively regulate the inflammatory response in polymicrobial sepsis." 07/01/2010 - "We hypothesized that beta-arrestin 2 is a critical modulator of inflammatory response in experimental sepsis. " 07/01/2010 - "Beta-arrestin 2 negatively regulates sepsis-induced inflammation."
3.	Pain (Aches) 03/04/2013 - "Furthermore, although this pain model did not alter Ca2+ current density, the contribution of N-type Ca2+ channels to the total current appeared to be regulated by the presence of beta-arrestin 2. Our results indicate that there is an upregulation of delta opioid receptor function following chronic pain. " 12/24/1999 - "Moreover, they suggest that inhibition of beta-arrestin 2 function might lead to enhanced analgesic effectiveness of morphine and provide potential new avenues for the study and treatment of pain, narcotic tolerance, and dependence."
4.	Breast Neoplasms (Breast Cancer) 10/01/2009 - "beta-Arrestin 2 increased uptake of CXCL12 in cells expressing CXCR7, emphasizing the functional relevance of the interaction between CXCR7 and beta-arrestin 2. In an orthotopic xenograft model of human breast cancer, we used bioluminescence imaging to quantify changes in the association of CXCR7 and beta-arrestin 2. These studies demonstrate ligand-dependent interactions of CXCR7 with beta-arrestin 2 that promote accumulation of chemokines and establish an imaging assay for the dynamic regulation of CXCR7 by chemokines and candidate therapeutic agents in cell-based assays and living mice." 07/01/2009 - "Moreover, we found that the mRNA levels of LPA1, LPA2, beta-arrestin 2, and Ral GTPases are elevated in the advanced stages of breast cancer. "
5.	Urinary Bladder Neoplasms (Bladder Cancer) 10/02/2023 - "Mechanistic studies showed that WDR4 can promote the nuclear localization of DEAD-box helicase 20 (DDX20) and act as an adaptor to bind DDX20 and Early growth response 1 (Egr1), thereby inhibiting Egr1-promoted transcriptional expression of arrestin beta 2 (ARRB2) and ultimately contributing to the progression of bladder cancer. " 06/01/2008 - "Furthermore, TP-beta mediated multiple biological effects by signaling through either G-protein alpha subunit 12 or beta-arrestin 2. Treatment of mice with the TP receptor antagonist GR32191, alone or in combination with cisplatin, significantly delayed tumor onset and prolonged survival of mice transplanted with TCC-SUP bladder cancer cells compared with vehicle or cisplatin alone. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Messenger RNA (mRNA)
3.	Analgesics (Analgesic Drugs)
4.	Chemokines
5.	Cytokines
6.	Narcotics (Narcotic Analgesics)
7.	Morphine (MS Contin)
8.	Ligands
9.	Dopamine Receptors (Dopamine Receptor)
10.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)

Related Therapies and Procedures

1.	Therapeutics