DEAD Box Protein 58

A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

Also Known As:

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Jun: 1 article (01/2020)
2.	Jin, Shouheng: 1 article (01/2020)
3.	Xian, Huifang: 1 article (01/2020)
4.	Yang, Shuai: 1 article (01/2020)
5.	Zhang, Yuxia: 1 article (01/2020)
6.	Bendtzen, K: 1 article (10/2014)
7.	Enevold, C: 1 article (10/2014)
8.	Hermansen, M L F: 1 article (10/2014)
9.	Jacobsen, R S: 1 article (10/2014)
10.	Jacobsen, S: 1 article (10/2014)

Related Diseases

1.	Lupus Nephritis 10/01/2014 - "This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes. "
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 10/01/2014 - "This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes. "
3.	malar rash 10/01/2014 - "This study aimed to demonstrate possible associations between genetic polymorphisms in Toll-like receptor 3, interferon induced with helicase C domain 1 (IFIH1) and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 and systemic lupus erythematosus (SLE), including the phenotypes lupus nephritis and malar rash, as well as the presence of autoantibodies against nucleic acid-containing complexes. "
4.	Ectopic Pregnancy 12/01/2023 - "For pregnancy location, 18 markers had an area under the curve (AUC) ≥0.80, with three being expressed more in ectopic compared to non-ectopic pregnancies: thyrotropin subunit beta, carbonic anhydrase 3, and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. " 05/05/2023 - "For pregnancy location, 18 markers had an area under the curve (AUC) ≥ 0.80, with three being expressed more in ectopic compared to non-ectopic pregnancies: thyrotropin subunit beta, carbonic anhydrase 3, and DEAD (Asp-Glu-Ala-Asp) box polypeptide 58. "
5.	Vesicular Stomatitis 01/01/2020 - ": ATG: Autophagy-related; Baf A1: Bafilomycin A1; DDX58/RIG-I: DEAD [Asp-Glu-Ala-Asp] box polypeptide 58; EV: Empty vector; IC poly[I:C]: Intracellular polyriboinosinic polyribocytidylic acid; IFIH1/MDA5: Interferon induced with helicase C domain 1; IFN: Interferon; ISG15: ISG15 ubiquitin like modifier; IKBKE: Inhibitor of nuclear factor kappa B kinase subunit epsilon; IRF3: Interferon regulatory factor 3; KO: Knockout; LRRC: Leucine rich repeat containing; MAVS: Mitochondrial antiviral signaling protein; CGAS/MB21D1: Cyclic GMP-AMP synthase; SeV: Sendai virus; siRNA: small interfering RNA; SQSTM1/p62: Sequestosome 1; TBK1: TANK binding kinase 1; TLR: Toll like receptor; TMEM173/STING: Transmembrane protein 173; VSV: Vesicular stomatitis virus; WT: Wild type."

Related Drugs and Biologics

1.	IFIH1 Interferon-Induced Helicase
2.	Toll-Like Receptor 3
3.	Nucleic Acids
4.	Autoantibodies
5.	Thyrotropin (Thyroid-Stimulating Hormone)
6.	Carbonic Anhydrases (Carbonic Anhydrase)
7.	Toll-Like Receptors (Toll-Like Receptor)
8.	Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)
9.	Small Interfering RNA (siRNA)
10.	Ubiquitin