Forkhead Box Protein O3

A forkhead box transcription factor and transcriptional activator which triggers type 1 programmed cell death (APOPTOSIS) in the absence of APOPTOSIS INHIBITING PROTEINS, including neuronal cell death induced by OXIDATIVE STRESS. It recognizes and binds to the DNA sequence 5'-(AG)TAAA(TC)A-3' and also functions in post-transcriptional regulation of the c-MYC PROTO-ONCOGENE.

Also Known As:

Networked: 29 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chung, Young Min: 2 articles (12/2021 - 07/2010)
2.	Hu, Mickey C-T: 2 articles (12/2021 - 07/2010)
3.	Tsai, Wen-Bin: 2 articles (12/2021 - 07/2010)
4.	Zhang, Yan: 2 articles (01/2020 - 01/2020)
5.	Khan, Pragya P: 1 article (12/2021)
6.	Larrick, James W: 1 article (12/2021)
7.	Qiao, Yanli: 1 article (12/2021)
8.	Wang, Hong: 1 article (12/2021)
9.	Yu, Bo: 1 article (12/2021)
10.	Cantley, Lewis C: 1 article (01/2021)

Related Diseases

1.	Infections 01/01/2020 - "Infection with melusin-expressing adeno-associated virus ameliorated contractile properties of 7 day unloaded muscles (P ≤ 0.05) and relieved myofiber atrophy (-33%) by reducing Atrogin-1 and MurF-1 transcripts (P ≤ 0.002), despite of a two-fold increase in FoxO3 protein levels (P = 0.03). " 04/25/2023 - "Following infection in Kashmir favorella, three differentially expressed genes Nuclear Factor Kappa B (NF-κB1), Forkhead Box Protein O3 (FOXO3) and Paired box 5 (Pax5) were identified. " 01/01/2020 - "Furthermore, bioinformatics analysis and luciferase reporter assay demonstrated that miR-155-5p directly targeted forkhead box protein O3 (FOXO3) and negatively regulated FOXO3/IRF7 axis, an important regulatory pathway for type I IFN production during EV71 infection. "
2.	Atrophy 01/01/2020 - "Infection with melusin-expressing adeno-associated virus ameliorated contractile properties of 7 day unloaded muscles (P ≤ 0.05) and relieved myofiber atrophy (-33%) by reducing Atrogin-1 and MurF-1 transcripts (P ≤ 0.002), despite of a two-fold increase in FoxO3 protein levels (P = 0.03). "
3.	Neoplasms (Cancer) 07/01/2019 - "The aim of the present study was to investigate the impact of miR-148a on tumor cell viability and invasion via targeting forkhead box protein O3 (FOXO3). " 01/01/2020 - "We found remarkably decreased expression of forkhead box 3 (FoxO3) protein, a tumor inhibitor, in 5-FU-resistant SW620 and HCT-8 (SW620/5-FU and HCT-8/5-FU) cells. " 07/02/2010 - "Silencing betaTrCP1 augments FOXO3 protein level, resulting in promoting cellular apoptosis in cancer cells. " 07/02/2010 - "In animal models, increasing FOXO3 protein level by silencing betaTrCP1 suppresses tumorigenesis, whereas decreasing FOXO3 by over-expressing betaTrCP1 promotes tumorigenesis and tumor growth in vivo. " 12/01/2021 - "We showed that PD-L1 protein level was inversely associated with FOXO3 protein level in patients with ovarian, breast, and hepatocellular tumors. "
4.	Rectal Neoplasms (Rectal Cancer) 05/01/2023 - "High expression of cytoplasmic FOXO3 protein associated with poor prognosis of rectal cancer patients: A study from Swedish clinical trial of preoperative radiotherapy to big database analysis."
5.	Lung Neoplasms (Lung Cancer) 10/01/2017 - "The current study demonstrated that the selected dose of Kyn significantly upregulated the FOXO3 protein rather than FOXO3 messenger RNA (mRNA) in the lung cancer 95D cells. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Ubiquitin
3.	Proteins (Proteins, Gene)
4.	Forkhead Box Protein O1
5.	NF-kappa B (NF-kB)
6.	Transcription Factors (Transcription Factor)
7.	Metformin (Glucophage)
8.	Prolyl Hydroxylases (Prolyl Hydroxylase)
9.	Anaphase-Promoting Complex-Cyclosome Apc11 Subunit
10.	B7-H1 Antigen

Related Therapies and Procedures

1.	Radiotherapy
2.	Aftercare (After-Treatment)