Mitochondrial Uncoupling Proteins

Mitochondrial anion carrier proteins that function as dimers and form proton channels in the INNER MITOCHONDRIAL MEMBRANE which creates proton leaks and uncouples OXIDATIVE PHOSPHORYLATION from ATP synthesis, resulting in the generation of heat instead of ATP.

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Networked: 397 relevant articles (10 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Roca, Pilar: 7 articles (08/2013 - 07/2002)
2.	Oliver, Jordi: 5 articles (08/2013 - 01/2009)
3.	Valle, Adamo: 4 articles (08/2013 - 01/2009)
4.	Kakuma, Tetsuya: 4 articles (01/2013 - 06/2003)
5.	Masaki, Takayuki: 4 articles (01/2013 - 06/2003)
6.	Yoshimatsu, Hironobu: 4 articles (01/2013 - 06/2003)
7.	Harper, Mary-Ellen: 4 articles (08/2006 - 08/2002)
8.	Barnstable, Colin J: 3 articles (05/2022 - 11/2003)
9.	Crispim, Daisy: 3 articles (11/2020 - 01/2013)
10.	Jin, Xi: 3 articles (01/2017 - 05/2009)

Related Diseases

1.	Insulin Resistance 10/01/2017 - "Serum levels of uncoupling proteins in patients with differential insulin resistance: A community-based cohort study." 08/01/2005 - "Decreased uncoupling protein (UCP)3 is associated with insulin resistance in muscle of pre-diabetic and diabetic individuals, but the function of UCP3 remains unclear. " 02/23/2001 - "An up-regulation of skeletal muscle uncoupling proteins (UCPs) has been associated with physiologic states of insulin resistance and enhanced fat metabolism in rodents. " 02/23/2001 - "Upregulation of uncoupling protein homologues in skeletal muscle but not adipose tissue in posttraumatic insulin resistance." 03/17/2022 - "Therefore, in this review, we gathered up-to-date knowledge on skeletal muscle uncoupling proteins and their effect on insulin sensitivity in mouse models of obesity and diabetes."
2.	Obesity 01/01/2017 - "Studies have described how genetics contributes to the development of obesity, and uncoupling proteins 1 and 2 (UCP1 and UCP2) and beta-3-adrenoceptor (ADRB3) have been implicated in the metabolic pathways that culminate in this condition. " 01/01/2016 - "Uncoupling proteins 2 (UCP2) plays an important role in energy regulation, previous studies suggested that UCP2 is an excellent candidate gene for human obesity and growth-related traits in cattle and chicks. " 01/01/2014 - "The relationship between uncoupling protein (UCP) 1-3 polymorphisms and susceptibility to obesity has been investigated in several genetic studies. " 08/15/2008 - "The present study reports that the I. paraguariensis extract can have a protective effect against a HFD-induced obesity in rats through an enhanced expression of uncoupling proteins and elevated AMPK phosphorylation in the visceral adipose tissue." 03/17/2022 - "From this perspective, uncoupling proteins were studied in correlation to the pathogenesis of diabetes and obesity and their possible treatments. "
3.	Type 2 Diabetes Mellitus (MODY) 01/01/2013 - "Some studies have reported associations between five uncoupling protein (UCP) 1-3 polymorphisms and type 2 diabetes mellitus (T2DM). " 01/01/2011 - "this study examined the association of -866G/A, Ala55Val, 45bpI/D, and -55C/T polymorphisms at the uncoupling protein (UCP) 3-2 loci with type 2 diabetes in Asian Indians. " 07/28/2022 - "Protective Role of Mitochondrial Uncoupling Proteins against Age-Related Oxidative Stress in Type 2 Diabetes Mellitus." 01/01/2021 - "The relationship between uncoupling protein (UCP) 1-3 polymorphisms and susceptibility to type 2 diabetes mellitus (T2DM) has been extensively studied, while conclusions remain contradictory. " 12/01/2018 - "There are disparities for the association between uncoupling proteins (UCP) and type 2 diabetes (T2DM). "
4.	Mitochondrial Diseases (Mitochondrial Disease) 07/01/2012 - "Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction." 01/01/2019 - "Although this process was originally considered a mitochondrial dysfunction, the identification of UCP-1 as an endogenous physiological uncoupling protein suggests that the process could be involved in many other biological processes. " 01/01/2016 - "During the later stage of acute heat stress, down-regulation of avian uncoupling protein worsens the oxidative stress situation causing mitochondrial dysfunction and tissue damage. " 02/01/2013 - "Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude." 11/01/2013 - "Numerous studies link UCP2, a member of the uncoupling protein family, to protection of neurons from mitochondrial dysfunction and oxidative damage in various mouse models of acute stress and neurodegeneration, including Parkinson's disease. "
5.	Morbid Obesity 12/01/1996 - "Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity." 08/01/2015 - "The catalytic antioxidant MnTBAP was administered to the uncoupling protein-diphtheria toxin A (UCP-DTA) mouse model of insulin resistance (IR) and obesity, at early and late time points in the evolution of IR, and to db/db mice with severe obesity and type-two diabetes. " 12/14/2009 - "In the present study, we show that wholebody disruption of Brd2, an unusual MHC gene, causes lifelong severe obesity in mice with pancreatic islet expansion, hyperinsulinaemia, hepatosteatosis and elevated pro-inflammatory cytokines, but, surprisingly, enhanced glucose tolerance, elevated adiponectin, increased weight of brown adipose tissue, heat production and expression of mitochondrial uncoupling proteins in brown adipose tissue, reduced macrophage infiltration in white adipose tissue, and lowered blood glucose, leading to an improved metabolic profile and avoiding eventual Type 2 diabetes. "

Related Drugs and Biologics

1.	Peroxisome Proliferator-Activated Receptors (PPAR)
2.	Glucose (Dextrose)
3.	Adenosine Triphosphate (ATP)
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Insulin (Novolin)
7.	Antioxidants
8.	Cytokines
9.	Mitochondrial DNA (mtDNA)
10.	Reactive Oxygen Species (Oxygen Radicals)

Related Therapies and Procedures

1.	Plant-Based Diet
2.	Vegan Diet (Diet, Vegan)
3.	Bariatric Surgery
4.	Caloric Restriction
5.	Punctures