Suppressor of Cytokine Signaling 3 Protein

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

Also Known As:

Networked: 46 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	La Manna, Sara: 2 articles (04/2022 - 05/2020)
2.	Leone, Marilisa: 2 articles (04/2022 - 05/2020)
3.	Marasco, Daniela: 2 articles (04/2022 - 05/2020)
4.	Mercurio, Flavia Anna: 2 articles (04/2022 - 05/2020)
5.	Cenci, Tonia: 2 articles (05/2018 - 05/2017)
6.	Martini, Maurizio: 2 articles (05/2018 - 05/2017)
7.	Pierconti, Francesco: 2 articles (05/2018 - 05/2017)
8.	Rodov, Sofya: 2 articles (10/2006 - 11/2004)
9.	Vanasse, Gary J: 2 articles (10/2006 - 11/2004)
10.	Zieske, Arthur W: 2 articles (10/2006 - 11/2004)

Related Diseases

1.	Acute Lung Injury 05/04/2023 - "SOCS3 Protein Mediates the Therapeutic Efficacy of Mesenchymal Stem Cells against Acute Lung Injury."
2.	Inflammation (Inflammations) 01/01/2016 - "In this study, we report that SOCS3 protein was elevated in bronchoalveolar lavage fluid of both virus- and bacteria-infected mice, as well as in an in vivo LPS model of acute inflammation. " 05/14/2020 - "Recombinant SOCS3 protein suppresses the effects of inflammation, and its deletion in neurons or in immune cells increases pathological blood vessels growth. " 11/10/2014 - "SOCS3 protein plays a vital role in immune processes and inflammation of the central nervous system. " 03/01/2010 - "Increased expression of SOCS3 protein was identified in liver specimens from patients with chronic HBV-infection and this correlated with the severity of liver inflammation. " 04/09/2022 - "SOCS3 (suppressor of cytokine signaling 3) protein suppresses cytokine-induced inflammation and its deletion in neurons or immune cells increases the pathological growth of blood vessels. "
3.	Hepatocellular Carcinoma (Hepatoma) 10/01/2015 - "Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. " 01/01/2018 - "The expression of SOCS3 mRNA in hepatocellular carcinoma cells was higher and SOCS3 protein expression was down-regulated or up-regulated in the knockdown or overexpression of BORIS mRNA hepatocarcinoma cells,so BORIS has a positive regulatory effect on SOCS3 protein expression in hepatocarcinoma cells. "
4.	Neoplasms (Cancer) 01/31/2023 - "The SOCS3 protein expression and SOCS3 promoter methylation status of the tumor tissues in these patients were also tested by immunohistochemistry and polymerase chain reaction (PCR), respectively. " 07/01/2016 - "Interestingly vice versa, SOCS3 protein levels were significantly higher in tumor tissue than in healthy tissue. " 05/01/2017 - "Moreover we demonstrated that the immunohystochemical analysis of SOCS3 protein expression in prostatic cancer biopsies may provide a useful and easier method than SOCS3 methylation analysis to individuate in cancer with intermediate-high grade Gleason score a subgroup of prostate cancer with a more aggressive behavior. " 01/01/2017 - "SOCS3 protein, the negative regulatory protein of JAK-STAT signaling pathway, may also plays critical regulatory roles in cancer initiation and progression. " 03/23/2018 - "SOCS3 protein may be a useful indicator for malignancy and prognosis of colorectal carcinoma and also a new target for gene therapy."
5.	Infections 02/13/2014 - "HSV-1 infection increased the number of Socs3 positive cells and modified the intracellular distribution of Socs3 protein, in infected cells. " 03/01/2010 - "In accordance with the IHC-findings, in vitro analyses demonstrated that HBV infection of HuH7 cells was associated with increased expression of SOCS3 protein. " 06/01/2004 - "In conclusion, the SOCS3 protein appears to be mainly responsible for the suppression of IFN signaling and IFN production that occurs during HSV-1 infection." 06/01/2004 - "Maximal levels of SOCS3 protein were detected at around 1 to 2 h after infection. " 03/01/2010 - "Increased expression of SOCS3 protein was identified in liver specimens from patients with chronic HBV-infection and this correlated with the severity of liver inflammation. "

Related Drugs and Biologics

1.	Cytokines
2.	Proteins (Proteins, Gene)
3.	Messenger RNA (mRNA)
4.	Tyrosine (L-Tyrosine)
5.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
6.	Leptin
7.	Insulin (Novolin)
8.	Endocannabinoids
9.	Chemokine CXCL6
10.	Janus Kinase 2

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)