Endoglin

A membrane glycoprotein and ANGIOGENESIS FACTOR that is expressed by cells of the VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; and MONOCYTES. It functions as a co-receptor for TRANSFORMING GROWTH FACTOR BETA and modulates CELL ADHESION. Mutations in the endoglin gene are associated with cases of HEREDITARY HEMORRHAGIC TELANGIECTASIA.

Also Known As:

Networked: 1289 relevant articles (30 outcomes, 222 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bernabeu, Carmelo: 42 articles (01/2022 - 11/2002)
2.	Karumanchi, S Ananth: 31 articles (01/2019 - 06/2006)
3.	Letarte, Michelle: 26 articles (01/2017 - 11/2002)
4.	Bernabéu, Carmelo: 23 articles (12/2020 - 11/2002)
5.	Pericacho, Miguel: 22 articles (03/2022 - 03/2006)
6.	Tong, Stephen: 21 articles (01/2022 - 01/2012)
7.	Botella, Luisa M: 20 articles (06/2019 - 11/2002)
8.	Nachtigal, Petr: 18 articles (03/2021 - 01/2006)
9.	Arthur, Helen M: 18 articles (11/2020 - 04/2003)
10.	Vary, Calvin P H: 18 articles (02/2017 - 12/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2015 - "Endoglin protein, which plays an important role in angiogenesis, seems to be a target of interest for detection of cancer and for prediction of therapeutic efficacy. " 04/01/2013 - "Considering the promising results from various in vitro studies, in vivo animal models and the first clinical trial targeting endoglin, we are convinced that endoglin is a valuable tool for the diagnosis, visualization and ultimately treatment of solid cancers." 12/01/2010 - "Higher tumor endoglin expression was associated with poor overall (p = 0.021) and disease-free (p = 0.032) survival in univariate analysis, and was an independent predictor in Cox multivariate analysis (p = 0.001 and p = 0.038, respectively). " 11/01/2017 - "Increased expression of endoglin in primary tumors prior to NAC correlated with improved response in primary tumors (P=0.019) or in primary tumors and regional lymph nodes (P=0.014), when compared with reduced expression of endoglin. " 04/01/2022 - "The results of the study indicate that the increased expression of endoglin in high-grade malignancies contributes to their aggressive nature."
2.	Neoplasm Metastasis (Metastasis) 01/01/2009 - "An association of a soluble form of endoglin with lymph node and distant metastases has recently been reported in two studies. " 01/01/2008 - "An association of a soluble form of endoglin with lymph node and distant metastases has recently been reported in two studies. " 12/15/2018 - "We investigated whether the TGF-β family coreceptor endoglin is involved in CAF-mediated invasion and metastasis. " 03/01/2016 - "There was no significant association between EphA2 and the rate of metastases (p = 0.196), endoglin expression (p = 0.652), VM (p = 0.267) or with any other clinical or histopathological factors (p < 0.05). " 03/03/2011 - "Consistent with these data, ectopic expression of endoglin in MDA-MB-231 cells blocks TGF-β-enhanced cell motility and invasion and reduces lung colonization in an in vivo metastasis model. "
3.	Pre-Eclampsia (Preeclampsia) 09/15/2015 - "YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia." 11/01/2016 - "Soluble endoglin improved predictive values for preeclampsia in patients with abnormal uterine Doppler." 01/01/2022 - "Previous studies have focused on a narrow window in gestation and have not included the maternal blood concentration of soluble endoglin, an important antiangiogenic factor up-regulated in preeclampsia. " 07/01/2021 - "This study aimed to evaluate soluble endoglin (sEng) in urine as a preeclampsia predictor. " 03/01/2021 - "Further studies are required to support the use of soluble endoglin as a diagnostic tool for preeclampsia in clinical settings."
4.	Colorectal Neoplasms (Colorectal Cancer) 05/15/2010 - "Taken together, this study shows that MMP-14 mediates endoglin shedding, which may regulate the angiogenic potential of endothelial cells in the (colorectal) tumor microenvironment." 07/01/2022 - "Endoglin was observed to be more upregulated in colorectal carcinomas and associated with poor survival outcomes, compared to healthy controls. " 01/01/2020 - "Endoglin-expressing Tregs were also detected in human colorectal cancer specimens. " 01/01/2020 - "Finally, human colorectal cancer specimens were analyzed for presence of endoglin-expressing regulatory T cells (Treg). " 12/15/2018 - "In zebrafish, endoglin-expressing fibroblasts enhanced colorectal tumor cell infiltration into the liver and decreased survival. "
5.	Lymphatic Metastasis 03/01/2008 - "The addition of endoglin to a standard preoperative model (including PSA, clinical stage, and biopsy Gleason sum) significantly improved its accuracy for prediction of lymph node metastasis from 89.4% to 97.8% (P < 0.001). " 01/01/2022 - "The addition of endoglin to the preoperative standard model improved its discrimination for prediction of lymph node metastasis, ≥pT3 disease, NOCD, and RFS (differential increases in C-indices: 10%, 5%, 5.8%, and 4%, respectively). Preoperative plasma endoglin is associated with features of biologically and clinically aggressive UCB as well as survival outcomes. " 01/01/2022 - "Higher preoperative endoglin level was independently associated with an increased risk for lymph node metastasis, ≥pT3 disease, and nonorgan confined disease (NOCD; all p < 0.001). " 03/01/2008 - "Logistic regression analyses were undertaken to evaluate whether endoglin improves the accuracy of a standard preoperative model for prediction of lymph node metastasis and to build a predictive nomogram. " 03/01/2008 - "The aim of the study was to evaluate whether preoperative plasma endoglin improves the prediction of lymph node metastases in patients with clinically localized prostate cancer. "

Related Drugs and Biologics

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2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	Monoclonal Antibodies
5.	Intercellular Signaling Peptides and Proteins (Growth Factors)
6.	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)
7.	Antibodies
8.	Small Interfering RNA (siRNA)
9.	Bevacizumab (Avastin)
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Ligation
4.	Prostatectomy (Retropubic Prostatectomy)
5.	Immunotherapy