Abstract | PURPOSE: Cancer-associated fibroblasts (CAF) are a major component of the colorectal cancer tumor microenvironment. CAFs play an important role in tumor progression and metastasis, partly through TGF-β signaling pathway. We investigated whether the TGF-β family coreceptor endoglin is involved in CAF-mediated invasion and metastasis. EXPERIMENTAL DESIGN: RESULTS: CONCLUSIONS:
Endoglin-expressing CAFs contribute to colorectal cancer progression and metastasis. TRC105 treatment inhibits CAF invasion and tumor metastasis, indicating an additional target beyond the angiogenic endothelium, possibly contributing to beneficial effects reported during clinical evaluations.See related commentary by Becker and LeBleu, p. 6110.
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Authors | Madelon Paauwe, Mark J A Schoonderwoerd, Roxan F C P Helderman, Tom J Harryvan, Arwin Groenewoud, Gabi W van Pelt, Rosalie Bor, Danielle M Hemmer, Henri H Versteeg, B Ewa Snaar-Jagalska, Charles P Theuer, James C H Hardwick, Cornelis F M Sier, Peter Ten Dijke, Lukas J A C Hawinkels |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 24
Issue 24
Pg. 6331-6344
(12 15 2018)
ISSN: 1557-3265 [Electronic] United States |
PMID | 29945992
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | ©2018 American Association for Cancer Research. |
Chemical References |
- Biomarkers
- Endoglin
- Ligands
- Transforming Growth Factor beta
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Topics |
- Animals
- Biomarkers
- Cancer-Associated Fibroblasts
(metabolism, pathology)
- Cell Line, Tumor
- Cell Movement
- Cell Survival
(genetics)
- Colorectal Neoplasms
(genetics, metabolism, mortality, pathology)
- Disease Models, Animal
- Endoglin
(genetics, metabolism)
- Fibroblasts
(metabolism)
- Fluorescent Antibody Technique
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Ligands
- Male
- Mice
- Neoplasm Metastasis
- Neoplasm Staging
- Prognosis
- Signal Transduction
- Transforming Growth Factor beta
(metabolism)
- Tumor Microenvironment
(genetics)
- Zebrafish
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