Nogo Proteins
Myelin proteins that are expressed as three isoforms: Nogo-A, Nogo-B, and Nogo-C. These share a C-terminal reticulon homology domain (RHD), consisting of two hydrophobic membrane domains flanking a 66 amino acid (Nogo-66) hydrophilic region. A long transmembrane region allows conformations that either span the entire membrane or fold into a hairpin conformation. Nogo inhibits NEURITE outgrowth and modulates wiring and the restriction of SYNAPTIC PLASTICITY in the adult central nervous system. It also regulates neurite fasciculation, branching, and extension in the developing nervous system.
Also Known As:
NI-220 Protein; NI-250 Protein; NI-35 Protein; NI-35-250; Neurite Growth Inhibitor 35-350; Nogo Protein; Nogo-66 Protein; Nogo-A Protein; Nogo-B Protein; Nogo-C Protein; Reticulon 4-B Protein; Reticulon-4 Protein; NI 220 Protein; NI 250 Protein; NI 35 250; NI 35 Protein; Neurite Growth Inhibitor 35 350; Nogo 66 Protein; Nogo A Protein; Nogo B Protein; Nogo C Protein; Reticulon 4 B Protein; Reticulon 4 Protein
Networked: 37
relevant articles (2 outcomes,
0 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Nie, Hu:
2 articles
(04/2022 - 11/2016)
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2. | Cheng, Li-Hong:
1 article
(05/2022)
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3. | Hong, Dong-Ying:
1 article
(05/2022)
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4. | Min, You-Jiang:
1 article
(05/2022)
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5. | Wang, Zhi-Qin:
1 article
(05/2022)
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6. | Yao, Hai-Hua:
1 article
(05/2022)
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7. | Ye, Wen-Guo:
1 article
(05/2022)
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8. | Cao, Yu:
1 article
(04/2022)
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9. | Li, Jia-Li:
1 article
(04/2022)
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10. | Chan, Sun-On:
1 article
(09/2021)
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Related Diseases
1. | Neurodegenerative Diseases (Neurodegenerative Disease)
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2. | Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
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3. | Spinal Cord Injuries (Spinal Cord Injury)
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4. | Neoplasms (Cancer)
07/12/2023
- " The reticulon-4 (RTN4) gene, encoding Nogo proteins, plays a critical role in apoptosis and cancer development, with genetic variations affecting its function. " 01/01/2018
- " Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. " 01/01/2014
- " Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. " 02/01/2011
- " We also confirmed the overexpression of the Nogo-A protein in 53 astrocytic and oligodendroglial tumors using Western blot analysis. " 06/15/2006
- " In recent years, knowledge about the physiological functions of the Nogo-A protein has grown considerably, and this molecule has evolved from being one of the most important axonal regrowth inhibitors present in central nervous system (CNS) myelin, to several other potentially important roles in different areas such as nervous system development, epilepsy, vascular physiology, muscle pathology and CNS tumors. "
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5. | Vascular Remodeling
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