Rotator Cuff Tear Arthropathy

Rapidly destructive shoulder joint and bone disease found mainly in elderly, and predominantly in women. It is characterized by SHOULDER PAIN; JOINT INSTABILITY; and the presence of crystalline CALCIUM PHOSPHATES in the SYNOVIAL FLUID. It is associated with ROTATOR CUFF INJURIES.

Also Known As:

Networked: 271 relevant articles (14 outcomes, 34 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteoarthritis
2.	Pain (Aches)
3.	Rotator Cuff Injuries
4.	Arthritis (Polyarthritis)
5.	Shoulder Fractures

Experts

1.	Edwards, T Bradley: 8 articles (06/2021 - 05/2007)
2.	Hsu, Jason E: 6 articles (12/2022 - 11/2016)
3.	Romeo, Anthony A: 6 articles (12/2020 - 03/2014)
4.	Williams, Gerald R: 6 articles (01/2020 - 02/2003)
5.	Matsen, Frederick A: 5 articles (12/2022 - 11/2016)
6.	Elkousy, Hussein A: 5 articles (06/2021 - 05/2012)
7.	Nicholson, Gregory P: 5 articles (12/2020 - 09/2011)
8.	Levine, William N: 5 articles (01/2016 - 03/2008)
9.	Bigliani, Louis U: 5 articles (02/2015 - 03/2008)
10.	Rasmussen, Jeppe V: 4 articles (01/2022 - 09/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Rotator Cuff Tear Arthropathy:

1.	theasinensin AIBA 07/01/2012 - "23 patients aged 68 ± 8.4 years with irreparable cuff-tear-arthropathy refractory to physiotherapeutic treatment were treated with Reco-Glenoid Total-Shoulder-Arthroplasty (TSA). " 02/01/2015 - "The study included 47 patients undergoing TSA for glenohumeral arthritis and 53 patients undergoing RTSA for rotator cuff tear arthropathy. " 03/01/2023 - "This cohort was matched (1:2) according to age, sex, body mass index (BMI), implant, and year of surgery with patients who had undergone HA or TSA for osteoarthritis or RSA for cuff tear arthropathy. " 09/01/2021 - "Patients with shoulder osteoarthritis and/or rotator cuff tear arthropathy indicated for anatomic or reverse TSA were included in this prospective study. " 06/01/2021 - "We included patients between the age of 50 and 89 years who underwent primary TSA for osteoarthritis with intact rotator cuff or primary RSA for cuff tear arthropathy. "
2.	calcium phosphateIBA 06/01/2007 - "Controversy remains about the role of basic calcium phosphate crystals in the development of cuff tear arthropathy. " 08/01/1984 - "Milwaukee Shoulder syndrome: eleven additional cases with involvement of the knee in seven (basic calcium phosphate crystal deposition disease)." 10/01/1984 - "Histopathological and ultrastructural studies of synovium in Milwaukee shoulder syndrome--a basic calcium phosphate crystal arthropathy." 01/01/2023 - "Basic calcium phosphate (BCP) crystals contribute to several syndromes associated with tendon disease, including acute calcific tendinitis and Milwaukee shoulder syndrome. " 01/01/2014 - "Milwaukee shoulder syndrome (MSS) is a rare destructive, calcium phosphate crystalline arthropathy. "
3.	ApatitesIBA 02/01/2003 - "The current study evaluated the relative correlation of apatite crystal-induced inflammation and rotator cuff deficiency in the development of cuff tear arthropathy. " 04/01/2005 - "[Milwaukee shoulder syndrome (apatite associated destructive arthritis): therapeutic aspects]." 02/01/1996 - "It has been described by several authors under varied names: hemorrhagic shoulder of the elderly, Milwaukee shoulder syndrome, rapid destructive arthritis of the shoulder, apatite-associated destructive arthritis and idiopathic destructive arthritis of the shoulder. " 02/01/2000 - "Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition." 05/01/2011 - "Milwaukee shoulder syndrome or rapid destructive arthritis of the shoulder; is a particular form of arthritis which affects mainly elderly patients, predominantly women, with limited pain and sometimes neuropathic joints, rotator cuff tear, joint instability, mildly inflammatory or noninflammatory, blood-stained effusion, calcium apatite crystals, and marked joint and bone destruction. "
4.	Hyaluronic Acid (Hyaluronan)IBA 01/01/2011 - "Ultrasound-guided viscosupplementation of subacromial space in elderly patients with cuff tear arthropathy using a high weight hyaluronic acid: prospective open-label non-randomized trial."
5.	FibrinIBA 10/01/1984 - "Light and electron microscopic study of synovial specimens from four patients with the Milwaukee shoulder syndrome disclosed vascular congestion, villous and focal synovial lining cell hyperplasia, occasional giant cells, and fibrin deposition both within and on the surface of the synovium. "
6.	Durapatite (Hydroxylapatite)IBA 01/01/2017 - "Milwaukee shoulder syndrome (MSS) is a rare, rapidly destructive arthropathy associated with calcium hydroxyapatite crystal deposition. " 03/01/1983 - "Milwaukee Shoulder syndrome: a new crystal-induced arthritis syndrome associated with hydroxyapatite crystals--a case report." 03/01/2012 - "Milwaukee shoulder syndrome (MSS) describes a destructive shoulder arthropathy associated with of calcium hydroxyapatite and calcium pyrophosphate dihydrate crystals deposition found mainly in elderly women. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, ad neutral protease with rotator cuff defects. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. "
7.	Collagenases (Collagenase)FDA Link 08/01/1987 - "Milwaukee shoulder--synovial fluid contains no active collagenase." 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, ad neutral protease with rotator cuff defects. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. " 01/01/2018 - "Milwaukee Shoulder Syndrome (MSS) is a painful progressive arthropathy in which hydroxyapatite crystal deposition in synovial tissue induces lysosomal release of collagenase and neutral proteases. "
8.	Peptide Hydrolases (Proteases)FDA Link 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, ad neutral protease with rotator cuff defects. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. " 03/01/1981 - ""Milwaukee shoulder"--association of microspheroids containing hydroxyapatite crystals, active collagenase, and neutral protease with rotator cuff defects. " 01/01/2018 - "Milwaukee Shoulder Syndrome (MSS) is a painful progressive arthropathy in which hydroxyapatite crystal deposition in synovial tissue induces lysosomal release of collagenase and neutral proteases. " 10/01/1982 - "Incubation of minced, focally calcified, chondromatosis tissue obtained at operation from a patient with Milwaukee shoulder (rotator cuff defect and glenohumeral osteoarthritis associated with synovial fluid, hydroxyapatite crystals in microspheroidal masses, collagenase, and neutral protease) with partially purified mammalian synovial cell collagenase released masses of hydroxyapatite crystals of the same size as those originally found in the patient's synovial fluid. "
9.	SolutionsIBA 03/01/2023 - "Reverse total shoulder arthroplasty (RTSA) has been well-described as a surgical solution to manage rotator cuff tear arthropathy in elderly, low demand paitents. " 01/01/2022 - "Joint replacement in weight-bearing shoulders is an effective medium-term solution for cuff tear arthropathy and glenohumeral OA, mainly for addressing pain, with slight improvements in range of motion, depending on the initial pathology. " 12/05/2019 - "Our results showed how RSA is a real solution to improve quality of life and to restore pain-free shoulder ROM in patients where cuff tear arthropathy occurs. " 10/18/2017 - "Our results showed how reverse shoulder arthroplasty is a real solution to improve quality of life, to restore pain-free ROM, function and strength of the shoulder in patients where cuff tear arthropathy occurs."
10.	Calcium PyrophosphateIBA 03/01/2012 - "Milwaukee shoulder syndrome (MSS) describes a destructive shoulder arthropathy associated with of calcium hydroxyapatite and calcium pyrophosphate dihydrate crystals deposition found mainly in elderly women. " 02/01/2000 - "Familial osteoarthritis and Milwaukee shoulder associated with calcium pyrophosphate and apatite crystal deposition." 02/01/2015 - "While an acute joint attack caused by calcium pyrophosphate crystals can mimic a gout flare, basic calcium phosphate crystal arthritis gives rise to a series of clinical manifestations, the most severe of which are calcific periarthritis, mostly asymptomatic, and a highly destructive arthritis known as Milwaukee shoulder syndrome, which is characterized by painful articular attacks. " 06/01/1994 - "Monosodium urate, calcium pyrophosphate dihydrate, and basic calcium phosphate (carbonate-substituted hydroxyapatite and octacalcium phosphate) crystal aggregates are associated with gout, pseudogout, and cartilage degeneration (osteoarthritis, Milwaukee Shoulder/Knee Syndrome), respectively. "

Therapies and Procedures

1.	Arthroplasty 07/01/2023 - "Reverse shoulder arthroplasty (RSA) is a type of surgery that has been shown to be very effective in patients with cuff tear arthropathy. " 12/01/2022 - "Cuff tear arthropathy (CTA) can be successfully treated with various types of shoulder arthroplasty. " 08/01/2022 - "Although reverse total shoulder arthroplasty (RTSA) has been shown to be effective for the treatment of cuff tear arthropathy (CTA), the patient's inability to accurately recall their preoperative shoulder condition could skew their perception of the effectiveness of the procedure. " 02/01/2022 - "Reverse total shoulder arthroplasty is widely used for the treatment of cuff tear arthropathy. " 04/01/2013 - "Reverse shoulder arthroplasty (RSA) has shown promising results for cuff tear arthropathy but the indication has been extended to fracture sequelae and revision shoulder arthroplasty with different preconditions. "
2.	Hemiarthroplasty 03/01/2019 - "Extended humeral head hemiarthroplasty can provide a safe and effective alternative for the management of selected patients with rotator cuff tear arthropathy and preserved active motion." 07/18/2023 - "However, for patients with CTA having preserved active elevation, cuff tear arthropathy hemiarthroplasty (CTAH) may offer a cost-effective alternative that avoids the complications unique to RSA. " 01/01/2021 - "An extended humeral head hemiarthroplasty may provide a less invasive alternative for select patients with cuff tear arthropathy (CTA) and preserved glenohumeral active elevation. " 01/01/2021 - "The modern use of the extended humeral head (cuff tear arthropathy) hemiarthroplasty." 12/01/2019 - "Of these, five patients, including one with humeral neck fracture and absent rotator cuff and four with cuff tear arthropathy, underwent conversion to hemiarthroplasty. "
3.	Prostheses and Implants (Prosthesis) 04/01/2004 - "This study confirms the promising early results obtained with the inverted prosthesis in the treatment of a cuff-tear arthropathy. " 12/01/2022 - "Glenoid wear and its impact on clinical results after humeral head replacement using a single prosthesis in cuff tear arthropathy with more than 8 years of follow-up." 01/01/2015 - "In general, RSA for cuff tear arthropathy demonstrated higher improvements in Constant and American Shoulder and Elbow Society scores, and range of motion compared with revision of anatomic prosthesis, failed rotator cuff repair, and fracture sequelae. " 07/01/2012 - "The semi-constraint reconstruction glenoid prosthesis model in cuff-tear-arthropathy patients significantly improves shoulder function, however, it yields controversial results, with satisfactory results in male and poor results in female patients. " 01/01/2012 - "The main indication for the reverse prosthesis is painful rotator cuff tear arthropathy. "
4.	Shoulder Prosthesis 05/01/2008 - "Patients with rotator cuff tear arthropathy can be treated successfully with a reverse total shoulder prosthesis. " 01/01/2006 - "Re: Shoulder prostheses treating cuff tear arthropathy: a comparative biomechanical study." 11/01/2004 - "Shoulder prostheses treating cuff tear arthropathy: a comparative biomechanical study." 12/01/2021 - "Reverse shoulder prostheses are increasingly used for treatment of rotator cuff tear arthropathy and other degenerative shoulder diseases. " 10/01/2010 - "Distal deltoid recession is a less invasive, extra-articular procedure that may be considered an alternative to a shoulder prosthesis and other surgical options, including muscle transfers, in patients with cuff-tear arthropathy."
5.	Salvage Therapy 05/01/2023 - "This study suggests that a superior capsular reconstruction can yield results that are comparable to other known salvage treatment options in patients with large-to-massive, irreparable rotator cuff defects with no significant cuff tear arthropathy. " 12/01/2020 - " study suggests that a superior capsular reconstruction can yield results that are comparable or superior to other known salvage treatment options in patients with large to massive rotator cuff defects without significant cuff tear arthropathy. "