Brain Contusion

A bruise of the brain from an impact of the skull.

Also Known As:

Cerebellar Contusion; Cerebral Contusion; Contusio Cerebri; Cortical Contusion; Brain Contusions; Cerebellar Contusions; Cerebral Contusions; Contusion, Brain; Contusion, Cerebellar; Contusion, Cerebral; Contusion, Cortical; Contusions, Brain; Contusions, Cerebellar; Contusions, Cerebral; Contusions, Cortical; Cortical Contusions

Networked: 514 relevant articles (19 outcomes, 90 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Edema (Dropsy)
2.	Cerebral Infarction
3.	Brain Injuries (Brain Injury)
4.	Brain Ischemia (Cerebral Ischemia)
5.	Traumatic Subarachnoid Hemorrhage

Experts

1.	Hoane, Michael R: 18 articles (01/2019 - 05/2006)
2.	Holmin, Staffan: 8 articles (09/2006 - 06/2002)
3.	Mathiesen, Tiit: 7 articles (12/2014 - 06/2002)
4.	Chang, Ching-Ping: 6 articles (12/2019 - 01/2011)
5.	Scheff, Stephen W: 6 articles (01/2018 - 12/2002)
6.	Soustiel, Jean F: 6 articles (01/2017 - 01/2004)
7.	Anderson, Gail D: 6 articles (09/2015 - 09/2011)
8.	Kantor, Eric D: 6 articles (09/2015 - 09/2011)
9.	Sahuquillo, Juan: 5 articles (01/2020 - 10/2006)
10.	Simard, J Marc: 5 articles (01/2020 - 12/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Brain Contusion:

1.	Progesterone FDA LinkGeneric 06/01/2008 - "Efficacy of progesterone following a moderate unilateral cortical contusion injury." 01/20/2012 - "Male Wistar 20-month-old rats were subjected to a moderate unilateral parietal cortical contusion injury and were treated with or without progesterone (n=54/group). " 09/01/2011 - "Microarray-based transcriptional profiling was used to determine the effect of progesterone in the cortical contusion (CCI) model. " 05/01/1997 - "To test progesterone's possible antiperoxidation effect, we compared brain levels of 8-isoprostaglandin F2 alpha (8-isoPGF2 alpha), a marker of lipid peroxidation, 24, 48, and 72 h after cortical contusion in male rats treated with either progesterone or the oil vehicle. " 09/01/1994 - "Progesterone facilitates cognitive recovery and reduces secondary neuronal loss caused by cortical contusion injury in male rats."
2.	Glyburide (Glibenclamide)FDA LinkGeneric 01/09/2020 - "A Phase-2 study evaluating the safety and efficacy of intravenous glibenclamide (BIIB093) in brain contusion is actively enrolling subjects. " 10/01/2023 - "Glibenclamide for Brain Contusions: Contextualizing a Promising Clinical Trial Design that Leverages an Imaging-Based TBI Endotype." 01/01/2023 - "Our goal to inform TBI precision medicine is contextually timely given ongoing phase 2/planned phase 3 trials of glibenclamide in brain contusion. " 01/01/2023 - "Blinded randomized controlled preclinical trial of glibenclamide on MRI endophenotypes in two established severe TBI models: controlled cortical impact (CCI, isolated brain contusion) and CCI+hemorrhagic shock (HS, clinically common second insult). " 05/01/2017 - "This study investigated effects of oral glibenclamide on brain contusion volume and functional outcome of patients with moderate and severe traumatic brain injuries. "
3.	salicylhydroxamic acid (SHAM)IBA 01/01/2018 - "Temporal profiles of serum levels at baseline and post-injury were measured in male Sprague Dawley rats subjected to very mild-, mild unilateral-cortical contusion, or naïve surgery and in male Sprague Dawley rats following a diffuse TBI or sham surgery. " 01/01/2018 - "Moderate cortical contusion injury (CCI) or sham surgery was performed when the rats attained 60-70 days of age. " 04/01/2015 - "Fifty adult male SD rats were randomly divided into 0 h, 6 h, 12 h, 24 h, 3 d, 5 d, 7 d, 10 d after focal cerebral contusion, control and sham-operated groups (5 rats each group). " 02/01/2015 - "Then the rats were randomly allocated into 8 groups: 2 h, 6 h, 12 h, 1 d, 3 d, and 7 d after cerebral contusion, sham-operation and normal control. " 01/01/2012 - "A 2 × 2 (lesion × treatment) experimental design was constructed with 31 weight restricted male Long-Evans rats which received either bilateral cortical contusions to the medial frontal cortex or sham preparations following the acquisition of the SSRT task (matched based on pre-surgical performance). "
4.	Dexamethasone (Maxidex)FDA LinkGeneric 01/22/2021 - "This is a confirmative trial to elucidate the therapeutic efficacy of dexamethasone in a very specific group of TBI patients: patients with brain contusions and pericontusional edema. " 01/22/2021 - "The DEXCON TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of dexamethasone on the prognosis of TBI patients with brain contusions and pericontusional edema. " 01/22/2021 - "Dexamethasone for the treatment of traumatic brain injured patients with brain contusions and pericontusional edema: Study protocol for a prospective, randomized and double blind trial." 10/23/2020 - "The objective is to study the effect of dexamethasone in patients with brain contusions, and to assess its effect on the vasogenic component of the pericontusional edema.Prospective" 10/23/2020 - "-observational study to quantify, using magnetic resonance imaging, the volume of the edema before and after 10 days of dexamethasone in patients with brain contusions. "
5.	Apolipoproteins E (ApoE)IBA 12/29/2015 - "Our data demonstrate that the expression of ApoE and S-100 correlated with the progression of focal cerebral contusion. " 12/29/2015 - "Based on a rat model of cerebral contusion, immunohistochemistry was used to analyze the expressions of S-100 and ApoE at different time points after injury. " 02/01/2003 - "In 110 black Zulu-speaking patients with traumatic cerebral contusions, genotypes for APOE were analyzed. " 02/01/2003 - "Venous blood was collected at the time of admission to determine the APOE genotype in black Zulu-speaking patients who presented with traumatic cerebral contusions. " 12/29/2015 - "This study explored the effect of focal cerebral contusion on the expression of ApoE and S-100, and its significance in determining the time of brain injury. "
6.	Peptides (Polypeptides)IBA 10/01/2008 - "We investigated the effect of delivering an inhibitory peptide that neutralizes Nogo-A on neuronal recovery following mild cortical contusion injury. " 10/01/2008 - "Nogo-A inhibitory peptide (NEP1-40) increases pan-cadherin expression following mild cortical contusion injury in rats." 07/01/2007 - "The present study evaluated the preclinical efficacy of COG1410, a small molecule ApoE-mimetic peptide (1410 daltons), following cortical contusion injury (CCI). " 07/01/2007 - "The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury." 12/25/2010 - "COG1410, a small, novel ApoE-mimetic peptide derived from the receptor binding region of apolipoprotein E (ApoE), has been classified as anti-inflammatory in nature and improves motor, sensorimotor, and cognitive dysfunction following cortical contusion injury (CCI). "
7.	COG1410IBA 07/01/2007 - "The present study evaluated the preclinical efficacy of COG1410, a small molecule ApoE-mimetic peptide (1410 daltons), following cortical contusion injury (CCI). " 07/01/2007 - "The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performance and reduces injury magnitude following cortical contusion injury." 12/25/2010 - "COG1410, a small, novel ApoE-mimetic peptide derived from the receptor binding region of apolipoprotein E (ApoE), has been classified as anti-inflammatory in nature and improves motor, sensorimotor, and cognitive dysfunction following cortical contusion injury (CCI). " 01/01/2009 - "We have previously shown that a single dose of COG1410, a small molecule ApoE-mimetic peptide derived from the apolipoprotein E (ApoE) receptor binding region, improves sensorimotor and motor outcome following cortical contusion injury (CCI). "
8.	RolipramIBA 01/04/2013 - "Total parietotemporal cortical contusion and cavity volume were significantly increased in rolipram-treated as compared to vehicle-treated CCI animals. " 11/01/2007 - "Rolipram treatment restored cAMP to sham levels and significantly reduced cortical contusion volume and improved neuronal cell survival in the parietal cortex and CA3 region of the hippocampus. " 09/01/2012 - "However, postinjury administration of (±)-rolipram significantly increased cortical contusion volume and increased atrophy of the cortex compared with vehicle-treated animals at 10 days postinjury. "
9.	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/01/1999 - "Thus, injury-induced decreases in the expression of BDNF and trkB may confer vulnerability to neurons within the cortical contusion." 11/01/2018 - "We thus conclude that post-ischaemic ISRW exercise rehabilitation attenuates cognitive deficits, as well as brain contusions, in TBI rats by stimulating the cerebral HSP20/BDNF/TrkB signalling axis." 11/01/2018 - "In addition to increasing hippocampal and cortical expression of HSP20, brain-derived neurotrophic factor (BDNF), and the tropomyosin receptor kinase B (TrkB) ratio, PE rehabilitation significantly attenuated brain contusion and improved cognitive deficits in the rat model. " 06/23/2008 - "Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats."
10.	Phosphotransferases (Kinase)IBA 11/09/2021 - "Using a model of cerebral contusion and RIPK3 and mixed lineage kinase like knockout (MLKL-/-) mice, we found evidence for activation of RIPK3 and MLKL and assembly of a RIPK1-RIPK3-MLKL necrosome complex in pericontusional brain tissue. " 12/01/1999 - "We measured the expression of Cyclin D1 and its kinase cdk4, 48 h after induction of cortical contusion in the rat. " 11/01/2018 - "In addition to increasing hippocampal and cortical expression of HSP20, brain-derived neurotrophic factor (BDNF), and the tropomyosin receptor kinase B (TrkB) ratio, PE rehabilitation significantly attenuated brain contusion and improved cognitive deficits in the rat model. "

Therapies and Procedures

1.	Therapeutics 01/01/2017 - "The experimental simulation choosed permits to study the possibilities of application of neurogenic tissues in the brain contusion treatment, and to determine the therapy tactics." 08/01/1994 - "This method of bilateral cortical contusion demonstrates clear, reproducible results that would be required for the development of future pharmacologic therapies designed to promote functional recovery." 01/01/1990 - "The excision of contused brain tissue appears to be the only therapy currently available to alleviate the formation of extracellular oedema fluid in cerebral contusions. " 01/01/1979 - "Effect of therapy on prognosis of cerebral contusions." 01/01/2013 - "The first patient, a 20-year-old man who suffered severe brain contusion and subarachnoid haemorrhage after a fall downstairs, with refractory ICP of 35 mmHg, despite maximal medical therapy, eventually underwent decompressive craniectomy. "
2.	Transplantation 02/01/2014 - "In conclusion, transplantation of ADSC‑SCs significantly promoted functional recovery following brain contusion." 01/01/2013 - "The impact of enriched environment and transplantation of murine cortical embryonic stem cells on recovery from controlled cortical contusion injury." 12/01/2020 - "In this study, we used a unilateral cortical contusion injury (CCI) model of sensorimotor brain injury to examine the effects of human induced pluripotent stem cell (hiPSC) transplantation on pathology in male and female adult mice. " 01/01/2011 - "This study investigated whether transplantation of Schwann cells differentiated from adipose-derived stem cells (ADSC-SCs) of rats could promote functional improvement after contusion brain injury, with a focus on the effect on reactive gliosis. " 01/01/2011 - "In conclusion, transplantation of ADSC-SCs can effectively promote locomotor functional recovery and reduce reactive gliosis after contusion brain injury in rats."
3.	Artificial Respiration (Mechanical Ventilation) 05/25/2021 - "The results indicate that p6 point acupressure in the brain contusion patients under mechanical ventilation has been associated with improved blood pressure, pulse rate, and respiratory rate. " 05/25/2021 - "The effect of acupressure on the level of the blood pressure, respiratory rate, and heart rate in patients with the brain contusion under mechanical ventilation." 01/01/2014 - "A 24-year-old man had a motor vehicle accident with head injury and cerebral contusion who required mechanical ventilation support. " 10/01/1999 - "Both patients, a male 6 years, 6 months of age with a brain contusion and a male 2 years, 6 months of age who underwent craniectomy for Crouzon's disease, required prolonged mechanical ventilation and developed sepsis with multiple organ dysfunction. " 01/01/1980 - "The indication for mechanical ventilation was always associated injuries (cerebral contusion, para- and tetraplegia, aspiration, severe lung contusion) and not the instability of the thoracic cage."
4.	Acupressure (Shiatsu) 05/25/2021 - "The results indicate that p6 point acupressure in the brain contusion patients under mechanical ventilation has been associated with improved blood pressure, pulse rate, and respiratory rate. " 05/25/2021 - "The effect of acupressure on the level of the blood pressure, respiratory rate, and heart rate in patients with the brain contusion under mechanical ventilation." 05/25/2021 - "Acupressure by reduces muscle tension, improves blood circulation and stimulates endorphins secretion naturally reduce pain in these patients therefore the aim of this study was to evaluate effect of acupressure on the level of the blood pressure, respiratory rate, and heart rate in patients with the brain contusion under mechanical ventilation. "
5.	Decompressive Craniectomy 11/06/2013 - "Neurodegenerative diversity in human cortical contusion: histological analysis of tissue derived from decompressive craniectomy." 12/10/2012 - "Do traumatic brain contusions increase in size after decompressive craniectomy?" 01/01/2005 - "Exploring the limits of survivability: rational indications for decompressive craniectomy and resection of cerebral contusions in adults." 07/01/1979 - "Large decompressive craniectomy in management of severe cerebral contusion. " 01/01/1979 - "Assessment of outcome following large decompressive craniectomy in management of serious cerebral contusion. "