[APPLICATION OF ALLOGENIC TISSUE OF THE FETAL BRAIN CORTEX AND THE OLFACTORY BULB TISSUE FOR TREATMENT OF THE BRAIN CONTUSION IN RATS].

Abstract

Impact of the allogenic tissue transplantation of the fetal cerebral large hemispheres and the оlfactory bulb tissue (OBT) on the healing processes after the brain contusion was studied in experiment. The investigation was performed on mongrel male rats: in laboratory animals of the first group in the first day after open penetrating local cerebral trauma (OPLCT) the allogenic fetal nervous tissue fragment was transplanted into the formatted tissue defect; for the second group – in the first day after cerebral trauma the allogenic OBT fragment was transplanted into the formatted tissue defect; and for the third group (control) - the OPLCT was done without further transplantation of tissues. The impact of the allogenic fetal nervous tissue transplantation was demonstrated by more active participation of glial cells during the healing process course, and the OBT transplantation was followed by activation of neoangiogenesis processes , mainly in the injured brain. The experimental simulation choosed permits to study the possibilities of application of neurogenic tissues in the brain contusion treatment, and to determine the therapy tactics.

• Authors: R R Novikov, A A Shmeleva, V V Vaslovich
• Journal: Klinichna khirurhiia (Klin Khir) 2017 Issue 3 Pg. 48-50 ISSN: 0023-2130 [Print] Ukraine
• PMID: 30277349 (Publication Type: Journal Article)

Topics

• Animals
• Animals, Outbred Strains
• Brain Contusion (pathology, surgery, therapy)
• Fetal Tissue Transplantation (methods)
• Fetus
• Histocytochemistry
• Male
• Neovascularization, Physiologic
• Neuroglia (cytology, physiology)
• Neurons (cytology, physiology)
• Olfactory Bulb (cytology, transplantation)
• Rats
• Recovery of Function
• Transplantation, Homologous
• Wound Healing (physiology)
• Wounds, Penetrating (pathology, surgery, therapy)