NLR Proteins

Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding region and LEUCINE-rich repeats. Their general structure consists of any of a variety of effector domains at their N-termini such as a caspase recruitment domain (CARD), a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE of animals and plants. Members of the NLR protein family include the NOD SIGNALING ADAPTOR PROTEINS.

Also Known As:

NLR Protein; NOD-like Receptors; Nucleotide-binding Domain Leucine-rich Repeat Proteins; NOD like Receptor; NOD like Receptors; Nucleotide Binding Domain Leucine Rich Repeat Protein; Nucleotide binding Domain Leucine rich Repeat Proteins; Protein, NLR; Proteins, NLR; Receptor, NOD-like; Receptors, NOD-like; NOD-like Receptor; Nucleotide-Binding Domain Leucine-Rich Repeat Protein

Networked: 1729 relevant articles (31 outcomes, 178 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - NLR Proteins: 1729

Experts

1.	Kanneganti, Thirumala-Devi: 15 articles (01/2018 - 06/2007)
2.	Girardin, Stephen E: 12 articles (01/2020 - 01/2007)
3.	Núñez, Gabriel: 8 articles (01/2017 - 06/2007)
4.	Lamkanfi, Mohamed: 8 articles (08/2015 - 06/2007)
5.	Wang, Lei: 7 articles (11/2022 - 12/2015)
6.	Li, Xu: 7 articles (10/2022 - 11/2015)
7.	Wang, Jing: 7 articles (06/2022 - 09/2016)
8.	Li, Jing: 7 articles (01/2022 - 09/2017)
9.	Zhao, Jing: 7 articles (01/2021 - 01/2018)
10.	Muruve, Daniel A: 7 articles (01/2019 - 12/2007)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "Our study therefore concluded that QF may reduce airway inflammation in asthmatic mice by regulating respiratory microbiota, and to the possibly downregulate MAPK and Nod-like receptor signaling pathways as its underlying mechanism." 03/31/2015 - "To our knowledge, this is the first study on NOD-like receptors in platelets that link thrombotic events to inflammation." 01/01/2015 - "Recent studies have shown that mitochondrial production of ROS and inflammation may be closely linked through a redox sensor known as nod-like receptor pyrin domain-containing 3 (NLRP3). " 08/11/2023 - "KEGG pathway enrichment analysis showed that differentially expressed genes between PTB patients and healthy controls were significantly related to inflammation, such as the NOD-like receptor signaling pathway and NF-κB signaling pathway. " 05/01/2022 - "NOD-like receptor (NLR)X1 (NLRX1) is a negative regulator of inflammation by inhibiting nuclear factor-κB (NF-κB) signaling and downstream pro-inflammatory factors. "
2.	Hypoxia (Hypoxemia) 12/01/2021 - "Under hypoxic stress, the transcript levels of genes involved in the NOD-like receptor signaling pathway initially increased rapidly but then decreased over time, suggesting that the NOD-like receptor-mediated immune response plays an essential role in hypoxia tolerance and resistance in hybrid yellow catfish. " 10/07/2020 - "NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure." 09/29/2023 - "The effect of hypoxia-inducible factor 1α (HIF-1α) on NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation in the pathogenesis of sinonasal mucosa is unclear. " 01/01/2022 - "Enrichment analyses revealed that these DEARGs were mainly enriched in the nucleotide-binding oligomerization domain (NOD)-like receptor signaling pathway, PI3K-Akt signaling pathway, response to hypoxia, response to nutrient levels, and autophagy. " 01/01/2021 - "In addition, luteolin also downregulated hypoxia-inducible factor-1α (HIF-1α) and NOD-like receptor 3 (NLRP3) expression in septic neonates and in LPS-stimulated neonatal macrophages. "
3.	Porcine Reproductive and Respiratory Syndrome (PRRS) 07/01/2023 - "Cytosolic PRRs that include NOD-like receptors (NLRs) are crucial for inducing inflammatory processes in the liver. " 01/01/2022 - "Nod-Like Receptor (NLR) is the largest family of Pathogen Recognition Receptors (PRRs) that patrols the cytosolic environment. " 02/01/2021 - "NOD-like receptors (NLRs) are a subgroup of cytosolic PRRs. " 01/01/2020 - "Regulatory Nod-like receptors (NLRs) are a subgroup of the cytosolic NLR family of pathogen recognition receptors (PRRs). " 08/01/2016 - "Nod like receptors (NLRs) are a large group of cytoplasmic PRRs believed to play an important role in bacterial recognition in higher vertebrates. "
4.	Body Weight (Weight, Body) 11/01/2022 - "Orally supplemental zinc reduced (P = 0.007) the bacterial load in the liver and improved (P < 0.05) the body weight, the bursa index, the serum IgA content, the villus height/crypt depth ratio, and the NOD-like receptor family pyrin domain containing 3 (NLRP3) protein expression, as well as tended to increase (P = 0.064) the protein abundance of caspase-1 of the jejunum, but did not alleviate the high level of neutrophil proportion and IL-1β mRNA expression of the jejunum (P > 0.05). " 12/01/2020 - "Fabp4-Cre-mediated overexpression of omentin-1 significantly increased serum omentin-1 level, serum anti-inflammatory factor levels, and expression of M2-specific mRNAs; inhibited body weight and adipose tissue weight gain; improved glucose tolerance, insulin tolerance, and insulin sensitivity; decreased serum levels of insulin and proinflammatory factors, adipocyte size, and expression of M1-specific mRNAs; suppressed macrophage infiltration; downregulated expression of proinflammatory factors; upregulated expression of anti-inflammatory factors; and inhibited thioredoxin-interacting protein (TXNIP)/NOD-like receptor 3 (NLRP3) signaling in the adipose tissue of obese mice. "
5.	Neuroinflammatory Diseases 09/29/2023 - "The Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses indicated that the NOD-like receptor signaling pathway was inhibited in the neuroinflammation effects of exercise in aging mice in both brain regions. " 03/01/2020 - "The NOD-like receptor family pyrin domain containing 3 (NLRP3) is an important regulator of neuroinflammation. " 04/18/2023 - "NOD-like receptor NLRC5 promotes neuroinflammation and inhibits neuronal survival in Parkinson's disease models." 03/01/2022 - "The NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated neuroinflammation is linked to neuronal necroptosis in cerebral ischemia-reperfusion (I/R) injury, especially in cerebral ischemic penumbra. " 01/01/2022 - "In this study, we found that microglia were activated in M1 after SCI, which triggered Nod-like receptor protein 3 (NLRP3) related chronic neuroinflammation and neuronal damage in vivo. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Inflammasomes
3.	NF-kappa B (NF-kB)
4.	Toll-Like Receptors (Toll-Like Receptor)
5.	Nucleotides
6.	Cytokines
7.	Caspase 1 (ICE Protease)
8.	Toll-Like Receptor 4
9.	Reactive Oxygen Species (Oxygen Radicals)
10.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy
3.	Secondary Prevention
4.	Cardiopulmonary Resuscitation (CPR)
5.	Ligation