Talipes

Deformity in which the foot is misaligned with respect to the TALUS in the ANKLE JOINT. While mostly congenital, as in CLUBFOOT, acquired deformities are included. Acquired talipedes are often associated with other foot deformities such as SYNDACTYLY and POLYDACTYLY.

Also Known As:

Networked: 51 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Clubfoot (Talipes Equinovarus)
2.	Congenital Abnormalities (Deformity)
3.	Hypospadias
4.	Cryptorchidism (Undescended Testes)
5.	Malignant Hyperthermia

Experts

1.	Thalluri, V: 1 article (01/2022)
2.	Tremellen, K: 1 article (01/2022)
3.	Vollenhoven, B: 1 article (01/2022)
4.	Woodman, R J: 1 article (01/2022)
5.	Zander-Fox, D: 1 article (01/2022)
6.	Ali Mahdi, Abbas: 1 article (04/2021)
7.	Chaturvedi, Pradeep: 1 article (04/2021)
8.	Gehlot, Harshit: 1 article (04/2021)
9.	Mahendra, Mayank: 1 article (04/2021)
10.	Pandey, Vaishnavi: 1 article (04/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Talipes:

1.	Complement System Proteins (Complement)IBA 11/01/2001 - "This study provides long-term outcome data which can be used to complement current prenatal counseling and shows that in cases of fetal talipes diagnosed prenatally, 90% have a structural rather than a positional deformity. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2022 - "The findings of this study, the largest of its kind, suggest that caution should be heeded when prescribing corticosteroids to women undergoing IVF/ICSI, given that this study has now identified three previously unassociated serious neonatal complications (talipes, hypospadias and cryptorchidism), plus a potential alteration in sex ratio. " 01/01/2022 - "Children born with the aid of IVF/ICSI whose mothers were treated with adjuvant corticosteroids during the first trimester had an increased risk of cryptorchidism, hypospadias and talipes. "
3.	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 04/01/2021 - "Analysis OF C677T polymorphism in methylene tetrahydrofolate reductase (MTHFR) gene as a risk factor for congenital talipes equino varus (CTEV)."
4.	SulfotransferasesIBA 08/01/2017 - "Mutations in the carbohydrate sulfotransferase 14 gene (CHST14) encoding CHST14/dermatan 4-O-sulfotransferase-1 (D4ST1), which is responsible for the biosynthesis of DS, cause a recently delineated form of Ehlers-Danlos syndrome (EDS, musculocontractural type 1), an autosomal recessive connective tissue disorder characterized by congenital malformations (specific craniofacial features, and congenital multiple contractures) and progressive fragility-related complications (skin hyperextensibility, bruisability, and fragility with atrophic scars; recurrent dislocations; progressive talipes or spinal deformities; and large subcutaneous hematomas). "
5.	Proteins (Proteins, Gene)FDA Link 01/01/1977 - "The clinical picture was characterized by a recurrent syndrome of polyradiculoneurites with a slight protein cellular dissociation in the CSF, an expressed sensitive ataxia with elements of cerebellar disorders, a drop in the acuity of sight, audition, intellectual level and a deformation of the talipes of the Friedreich type. "
6.	Phenytoin (Dilantin)FDA LinkGeneric 12/01/2003 - "The malformations of the hands and feet, and the talipes deformity are potential effects of vascular disruption, a postulated fetal effect of both phenytoin and cigarette smoking. "
7.	Methotrexate (Mexate)FDA LinkGeneric 04/01/2012 - "Based on human case reports of methotrexate exposure during pregnancy, a methotrexate embryopathy has been described that includes growth deficiency, microcephaly, hypoplasia of skull bones, wide fontanels, coronal or lambdoidal craniosynostosis, upswept frontal scalp hair, broad nasal bridge, shallow supraorbital ridges, prominent eyes, low-set ears, maxillary hypoplasia, epicanthal folds, short limbs, talipes, hypodactyly, and syndactyly. "
8.	Gutta-Percha (Guttapercha)IBA 04/01/1866 - "Surgery: The Gutta-Percha Shoe in the Treatment of Talipes."
9.	Folic Acid (Vitamin M)FDA LinkGeneric 01/01/2018 - "The two most frequently reported anomalies were anencephaly that is potentially preventable through preconception folate supplementation, and talipes which can be corrected using relatively low cost interventions. "
10.	Dihydrotachysterol (AT 10)IBA 08/01/2005 - "There is no increased risks of limb reduction defects following CVS at 10 weeks or greater, but there is an increase in Talipes from "Early Amniocentesis." In the first trimester CVS is the safer procedure."

Therapies and Procedures

1.	Physical Therapy Modalities (Physical Therapy Technique) 01/01/2001 - "The purpose of this study was to assess the efficacy of early physical therapy in a series of 189 cases of congenital talipes equino-varus (CTEV) or clubfoot. " 01/01/2001 - "[Congenital talipes equino-varus or clubfoot: value of physical therapy (report of 189 cases)]."
2.	Foot Orthoses 07/01/2010 - "Effectiveness of modified ankle foot orthosis of low-temperature thermoplastics in idiopathic congenital talipes equino varus." 07/01/2010 - "The aim of this study was to study the effectiveness of modified ankle foot orthosis fabricated from low-temperature thermoplastics, as an alternative orthosis for the maintenance of correction in idiopathic congenital talipes equino varus (CTEV) deformity. "
3.	Orthotic Devices (Orthosis) 07/01/2010 - "The aim of this study was to study the effectiveness of modified ankle foot orthosis fabricated from low-temperature thermoplastics, as an alternative orthosis for the maintenance of correction in idiopathic congenital talipes equino varus (CTEV) deformity. "
4.	Osteotomy 11/01/1973 - "Osteotomy of the calcaneus and concomitant plantar stripping in children with talipes cavo-varus." 10/17/1891 - "Osteotomy Generally; with Special Reference to Tarsectomy in Advanced and Intractable Cases of Talipes Equino-Varus." 12/01/1890 - "III. Cuneiform Osteotomy for Congenital Talipes Varus." 03/01/1887 - "II. On the Treatment of Inveterate Talipes Equino-Varus by Osteotomy." 04/01/2006 - "Severe contraction talipes calvus can be straightened and capable of loading using Imhäuser's technique with wedge osteotomy and arthrodesis in Chopart's joint. "
5.	Therapeutics 03/01/1966 - "[Therapy of congenital talipes adductus]." 01/01/1958 - "[Therapy of congenital talipes]." 06/01/1955 - "[Therapy of paralytic talipes]." 01/01/1951 - "[Surgical therapy of paralytic talipes]." 05/01/1991 - "The complications brought on by apparatus-assisted therapy of talipes equinocavovarus deformities require additional treatment but do not depreciate the method."