Bone-Implant Interface

Region of interaction between the bone and PROSTHESES AND IMPLANTS which becomes bonded through cellular and extracellular interactions similar to OSSEOINTEGRATION.

Also Known As:

Bone-Prosthesis Interface; Bone Implant Interface; Bone Prosthesis Interface; Bone-Implant Interfaces; Bone-Prosthesis Interfaces; Interface, Bone-Implant; Interface, Bone-Prosthesis; Interfaces, Bone-Implant; Interfaces, Bone-Prosthesis

Networked: 180 relevant articles (1 outcomes, 19 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Goodman, Stuart B: 4 articles (01/2016 - 01/2011)
2.	Gulati, Karan: 3 articles (01/2021 - 01/2016)
3.	Raschke, Michael J: 3 articles (01/2019 - 12/2015)
4.	Schliemann, Benedikt: 3 articles (01/2019 - 12/2015)
5.	Nich, Christophe: 3 articles (01/2016 - 10/2013)
6.	Fahlgren, Anna: 3 articles (06/2013 - 04/2012)
7.	Arora, Himanshu: 2 articles (01/2021 - 01/2021)
8.	Fournier, Benjamin: 2 articles (01/2021 - 01/2021)
9.	Guo, Tianqi: 2 articles (01/2021 - 01/2021)
10.	Han, Pingping: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Osteolysis 09/01/2004 - "The purpose of the present study was to investigate the use of modified magnetic resonance imaging techniques involving commercially available software to visualize periprosthetic soft tissues, to define the bone-implant interface, and to detect the location and extent of osteolysis. " 05/01/1998 - "A new experimental implant model was developed to study whether local fluid pressure can induce osteolysis at a bone implant interface. " 02/01/1998 - "We developed an experimental implant model to study whether oscillating fluid pressure, applied during 2 hours a day, can lead to osteolysis at the bone implant interface. " 01/01/2023 - "Rationale: Inflammatory osteolysis, characterized by abundant immune cell infiltration and osteoclast (OC) formation, is a common complication induced by bacterial products and/or wear particles at the bone-prosthesis interface that severely reduces long-term stability after implantation. " 01/01/2023 - "Bone-implant interface analysis revealed osteolysis in 9 ankles (15%) and radiolucent lines in 33 ankles (55%) occurring at both component interfaces. "
2.	Infections 11/01/2021 - "This study evaluated the late resistance to haematogenous contamination by microbial pathogens of implants and bone-implant interface and the development of late clinical infection when cementless components with different surface or structural properties are implanted. " 09/01/2011 - "In another study using as a criterion for periprosthetic infection the increased (18)F-FDG activity at the bone-prosthesis interface of the femoral component, sensitivity, specificity, positive and negative predictive values for the (18)F-FDG PET study where 85%, 93%, 80% and 95%, respectively. " 12/04/2023 - "Infection and aseptic loosening can be seen as a lucency at the bone-implant interface which (if left untreated) can lead to loss of the implant. " 11/15/2019 - "Multiple percutaneous implant systems exist for clinical use internationally, each attempting to create a stable bone-implant interface while avoiding complications such as infection and loosening. " 01/01/2018 - "Only an acceptable diagnostic accuracy (sensitivity 81%; specificity 94%) was found when increased FDG uptake along the femoral bone-prosthesis-interface was considered positive for infection."
3.	Bone Resorption 01/01/2022 - "However, a limited area of bone-implant interface can increase the risk of peri-implant bone resorption due to occlusal forces. " 07/31/2021 - "Stress shielding was defined as the development of bone resorption around the prosthesis stem beginning at the bone/prosthesis interface. " 12/02/2020 - "Many features observed in literature, such as soft tissues covering on the bone-implant interface; crestal bone loss; the location of bone resorption bumps, were reproduced by the model and explained by analyzing the solid and fluid biophysical stimuli and (4) Conclusions: The results suggested the suitable depth, the steeper slope of the upper flanks, and flat roots of healing chambers can improve the bone ingrowth and osseointegration. " 10/03/2017 - "Although reducing stem stiffness can ameliorate the bone resorption, it increases stress at the bone-implant interface and can inhibit fixation. " 11/01/2015 - "The ability of PAR to inhibit PE-induced surface bone erosion may better reflect the in vivo situation, where bone resorption occurs on the surface at the bone-implant interface and may also be related to the role of osteocytes in this pathology."
4.	Pain (Aches) 07/01/1993 - " However, clinical studies of porous-coated prostheses have revealed findings of concern such as thigh pain, subsidence of the femoral prosthesis, and radiographic lucencies at the bone-prosthesis interface. " 01/01/1992 - "Special attention was paid to the high incidence of thigh pain, attempting to identify the cause through radiographic study of the bone-implant interface. " 12/01/2021 - "Affected patients noted symptoms of instability and reproducible pain at the bone-implant interface. " 01/01/2008 - "The most commonly reported complications related to cementless hip stems are loosening and thigh pain; both of these have been attributed to high levels of relative micromotion at the bone-implant interface due to insufficient primary fixation. " 01/01/1999 - "In order to better understand the mechanism responsible for pain and loosening, we thoroughly analysed the membranes surrounding the prosthesis and the bone-prosthesis interface in two trapezia, each containing a Ledoux cup, which were resected after unsuccessful implantation. "
5.	Osteoporosis 06/01/2015 - "The aim of this study was to evaluate bone healing at the bone-implant interface in rats with induced osteoporosis. " 09/01/2020 - "Osteoporosis alters the bio mechanics at the bone implant interface resulting in various degrees of fixation failure. " 01/01/2016 - "The presence of an osteoporosis drug may influence both bone quantity and quality at the bone/implant interface. " 07/01/2020 - "There are several clinically relevant questions related to the management of such cases: the effect of ageing; the initial osseointegration of implants, especially when cementless THA is used; the effect of medical osteoporosis treatment on bone-implant interface; the incidence of intraoperative and late periprosthetic fractures, and the long-term survival of both cemented and cementless total hip arthroplasty performed for proximal femoral fractures and hip osteoarthritis. " 01/01/2018 - "Our review will focus on minimodeling-based formation in 5 aspects below: 1. compare the minimodeling with remodeling regarding 10 items; 2. describe the histological observation to characterize remodeling and minimodeling formation sites; 3. present evidence of bone anabolic agents which start bone minimodeling; 4. discuss the mechanism and target cells involved in bone minimodeling; 5. interpretate the increased osteogenic potential and trabecular connectivity with minimodeling-based formation; 6. Depict modeling patterns of the bone implant interface and peri-implant osteogenesis in osteoporosis. "

Related Drugs and Biologics

1.	Cytokines
2.	Alendronate (Alendronate Sodium)
3.	Polyethylene (Polythene)
4.	polyetheretherketone
5.	Silk
6.	Hydrogels
7.	Titanium
8.	Diphosphonates (Bisphosphonates)
9.	Sitagliptin Phosphate (Januvia)
10.	Dental Implants (Dental Implant)

Related Therapies and Procedures

1.	Prostheses and Implants (Prosthesis)
2.	Experimental Implants
3.	Hip Replacement Arthroplasty (Total Hip Replacement)
4.	Bite Force (Occlusal Forces)
5.	Arthroplasty