Protein Corona

A layer of protein coating adsorbed by NANOPARTICLES upon entry into PLASMA or other protein-containing biological fluids, which affects how nanoparticles are internalized by cells and cleared from the body.

Also Known As:

Networked: 173 relevant articles (12 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Caracciolo, Giulio: 14 articles (04/2022 - 05/2013)
2.	Pozzi, Daniela: 13 articles (04/2022 - 05/2013)
3.	Digiacomo, Luca: 10 articles (04/2022 - 01/2016)
4.	Palchetti, Sara: 9 articles (01/2021 - 05/2013)
5.	Caputo, Damiano: 8 articles (04/2022 - 01/2019)
6.	Mahmoudi, Morteza: 7 articles (07/2021 - 01/2014)
7.	Quagliarini, Erica: 6 articles (04/2022 - 01/2020)
8.	Capriotti, Anna Laura: 6 articles (08/2020 - 05/2013)
9.	Chen, Chunying: 5 articles (01/2022 - 02/2015)
10.	Coppola, Roberto: 5 articles (01/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2022 - "Notably, to the best of our knowledge, the protein corona formed nanoprobes was exploited for direct tumor cell and tissue detection with high efficacy for the first time, demonstrating their promising potential in clinical tumor detection." 01/01/2022 - "Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy." 01/01/2021 - "Magnetothermal regulation of in vivo protein corona formation on magnetic nanoparticles for improved cancer nanotherapy." 02/27/2020 - "Our findings demonstrate that the protein corona formation by both healthy and Tf depleted human plasma diminishes the targeting efficacy of Au NPs within human cancer cells despite a preservation of targeting ability by plasma with excess Tf (10-fold). " 01/01/2022 - "In the in vitro and in vivo studies, the protein corona exhibited completely different effects on the active and passive cancer-targeting capability of the particles. "
2.	Inflammation (Inflammations) 07/19/2013 - "The protein corona may influence cellular uptake, inflammation, accumulation, degradation and clearance of the nanoparticles. " 08/01/2021 - "While the nanocarrier surface chemistry has long been the focus of protein corona formation, the influence of nanostructure has remained unclear despite established influences on biodistribution, clearance, and inflammation. " 01/05/2016 - "Protein corona acts as a protective shield against Fe3O4-PEG inflammation and ROS-induced toxicity in human macrophages." 05/14/2020 - "Protein corona fingerprinting to differentiate sepsis from non-infectious systemic inflammation." 04/14/2021 - "The protein corona also has many repercussions on cellular intake, inflammation, accumulation, degradation, and clearance of the nanoparticles from the body depending on the exposed part of the proteins. "
3.	Infections 08/28/2023 - "Effect of Protein Corona on the Specificity and Efficacy of Nanobioconjugates to Treat Intracellular Infections." 01/01/2021 - "The central aim of this short perspective is to suggest a few possible nanobased technologies (i.e., protein corona sensor array and magnetic levitation) that could discriminate COVID-19-infected people while still in the early stages of infection who are at high risk of death. " 08/14/2021 - "The present study enhances the understanding of the role of protein corona in the bio-behaviors of SARS-CoV-2, which may aid the more precise and personalized treatment for COVID-19 infection in the clinic." 10/06/2023 - "In view of the tunable physicochemical properties and the related unique biological behavior (e.g., size-, shape-, and surface charge-dependent penetration, protein corona endowed targeting, catalytic- and electronic-related oxidative stress, optical- and magnetic-associated hyperthermia, etc.), nanomaterials-based therapeutics are widely used for the treatment of biofilm-associated infections. " 11/01/2022 - "aureus-related osteomyelitis and pneumonia mice models, DSPG sLip was demonstrated as a promising antibiotic nanocarrier for managing MRSA infection, indicating the benefits of lipid composition-based protein corona modulation in liposomal antibiotic delivery for bacterial infection treatment."
4.	Hyperthermia 12/01/2013 - "For targeted hyperthermia applications the study of the formation of a protein corona around nanoparticles with site-specific biomolecules on the surface is essential to achieve improved circulation times in the blood and reduced non-specific uptake by non-targeted organs for a high specific accumulation in the target tissue." 05/01/2021 - "Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. " 01/08/2014 - "Potential changes in the protein corona following hyperthermia treatment may influence the final biological fate of plasmonic NPs in clinical applications and help elucidate safety considerations for hyperthermia applications. " 08/01/2022 - "Here, a protein corona-bridged GO nanoplatform with high drug loading, longstanding hyperthermia, and controllable drug release, was engineered for amplified tumor therapeutic benefits. " 10/06/2023 - "In view of the tunable physicochemical properties and the related unique biological behavior (e.g., size-, shape-, and surface charge-dependent penetration, protein corona endowed targeting, catalytic- and electronic-related oxidative stress, optical- and magnetic-associated hyperthermia, etc.), nanomaterials-based therapeutics are widely used for the treatment of biofilm-associated infections. "
5.	Brain Neoplasms (Brain Tumor) 12/28/2021 - "The formation of the ApoE-enriched protein corona significantly improved the cellular uptake of Aβ-CN-PMs on C6 cells and human umbilical vein endothelial cells (HUVECs) and enhanced permeability to the blood-brain tumor barrier in vitro. " 01/01/2021 - "The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood-brain barrier and attenuates their targeting ability to brain tumor." 11/01/2020 - "This work promised not only a potential protein corona-mediated COF-based drug delivery platform with good biocompatibility for effective and precise brain tumor therapy, but also an endogenous protein corona-mediated targeting strategy for general cancer therapy." 03/12/2021 - "We have demonstrated that precoating liposomal TMZ with a protein corona made of human plasma proteins can increase drug penetration in a 3D brain cancer model derived from U87 human glioblastoma multiforme cell line leading to marked inhibition of tumour growth. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Liposomes (Liposome)
3.	Therapeutic Uses
4.	Prodrugs
5.	maleimide
6.	Disulfides
7.	Apolipoproteins E (ApoE)
8.	Gd@C82(OH)22
9.	Gold
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Lasers (Laser)
4.	Precision Medicine
5.	Immunotherapy