Protein corona mediated liposomal drug delivery for bacterial infection management.

Abstract

Liposomes have been widely investigated as a class of promising antibiotic delivery systems for the treatment of life-threatening bacterial infections. However, the inevitable formation of protein corona on the liposomal surface can heavily impact in vivo performance. A better understanding of the effects of protein corona on liposomal behavior can significantly improve antibacterial liposomal drug development. Here, the critical role of protein corona in mediating liposome-bacteria interactions was elucidated. Adsorption of negatively charged protein on cationic liposome weakened electrostatic attraction-enhanced liposomal binding to the bacteria. Cumulative complement deposition on anionic liposome composed of phosphatidylglycerol (DSPG sLip) contributed to a superior binding affinity of DSPG sLip to planktonic bacteria and biofilms, which was exploited to enhance bacteria-targeted drug delivery. In both S. aureus-related osteomyelitis and pneumonia mice models, DSPG sLip was demonstrated as a promising antibiotic nanocarrier for managing MRSA infection, indicating the benefits of lipid composition-based protein corona modulation in liposomal antibiotic delivery for bacterial infection treatment.

• Authors: Qianwen Shao, Tianhao Ding, Feng Pan, Guanghui Li, Shun Shen, Jun Qian, Changyou Zhan, Xiaoli Wei
• Journal: Asian journal of pharmaceutical sciences (Asian J Pharm Sci) Vol. 17 Issue 6 Pg. 855-866 (Nov 2022) ISSN: 2221-285X [Electronic] Netherlands
• PMID: 36600900 (Publication Type: Journal Article)
• Copyright: © 2022 Shenyang Pharmaceutical University. Published by Elsevier B.V.