1- O- octadecyl- 2- O- (2- inositolylethyl)- glycero- 3- phosphatidylcholine

an analog of platelet activating factor (PAF); structure in first source

Also Known As:

1-O-octadecyl-2-O-(2-(myo-inositolyl)-ethyl)-sn-glycero-3-phosphatidylcholine; Ino-C2-PAF; inositol-C2-PAF

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Carbohydrates: 22023
- Sugar Alcohols: 143
  - Inositol: 2982
    - 1-O-octadecyl-2-O-(2-inositolylethyl)-glycero-3-phosphatidylcholine: 7
Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phospholipid Ethers: 36
        Platelet Activating Factor: 2984
        1-O-octadecyl-2-O-(2-inositolylethyl)-glycero-3-phosphatidylcholine: 7
Biological Factors: 2472
- Blood Coagulation Factors: 5376
  - Platelet Activating Factor: 2984
    - 1-O-octadecyl-2-O-(2-inositolylethyl)-glycero-3-phosphatidylcholine: 7
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Platelet Activating Factor: 2984
      - 1-O-octadecyl-2-O-(2-inositolylethyl)-glycero-3-phosphatidylcholine: 7

Experts

1.	Danker, Kerstin: 7 articles (10/2018 - 05/2010)
2.	Semini, Geo: 6 articles (10/2018 - 05/2010)
3.	Hildmann, Annette: 5 articles (10/2018 - 04/2011)
4.	Klein, Andreas: 3 articles (10/2018 - 07/2011)
5.	Lucka, Lothar: 2 articles (10/2018 - 02/2014)
6.	Shmanai, Vadim: 2 articles (10/2018 - 02/2014)
7.	Schön, Margarete: 2 articles (10/2014 - 02/2014)
8.	Schön, Michael P: 2 articles (10/2014 - 02/2014)
9.	Reutter, Werner: 2 articles (04/2011 - 05/2010)
10.	Bintig, Willem: 1 article (10/2018)

Related Diseases

1.	Inflammation (Inflammations) 02/01/2014 - "The induction of inflammation and the impact of Ino-C2-PAF were assessed in this system using a genome-wide microarray analysis. " 02/01/2014 - "To further evaluate the influence of Ino-C2-PAF we established an in vitro 2D-model of epidermal inflammation. " 02/01/2014 - "Inositol-C2-PAF down-regulates components of the antigen presentation machinery in a 2D-model of epidermal inflammation." 07/01/2011 - "Nevertheless, the most remarkable finding is represented by the ability of Ino-C2-PAF to downregulate a broad spectrum of genes associated with the regulation of the innate and acquired immune response and of genes linked to inflammation. " 05/01/2014 - "Furthermore, Ino-C2-PAF reduced the expression of genes encoding proteins associated with inflammation and the innate and acquired immune responses."
2.	Skin Diseases (Skin Disease) 10/01/2014 - "These findings suggested that Ino-C2-PAF is a potential candidate in the therapy of inflammatory skin diseases that include abnormal vascular functions. " 05/01/2010 - "We intend to highlight the potential of glycosidated phospholipids, especially Ino-C2-PAF, as a promising new group of drugs for the treatment of hyperproliferative and migration-based skin diseases."
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 10/01/2014 - "When the therapeutic potential of Ino-C2-PAF was assessed in two complementary mouse models of psoriasis, K5.hTGFβ1 transgenic and JunB/c-Jun-deficient mice, Ino-C2-PAF led to significant alleviation of the clinical symptoms and normalized the pathological cutaneous changes including vascularization. " 02/01/2014 - "Thus, it is conceivable that Ino-C2-PAF possess therapeutic potential for inflammatory skin disorders, such as psoriasis and allergic contact dermatitis. "
4.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 10/01/2018 - "We previously showed that the alkylphospholipid Inositol-C2-PAF inhibits the proliferation and migration of immortalized keratinocytes and the squamous carcinoma-derived cell line SCC-25. " 04/15/2011 - "Here, we show that Ino-C2-PAF also inhibits the motility of the skin-derived transformed cell lines HaCaT and squamous cell carcinoma (SCC)-25. "
5.	Allergic Contact Dermatitis 02/01/2014 - "Thus, it is conceivable that Ino-C2-PAF possess therapeutic potential for inflammatory skin disorders, such as psoriasis and allergic contact dermatitis. "

Related Drugs and Biologics

1.	Phospholipids (Phosphatides)
2.	Cytostatic Agents
3.	Cytokines
4.	Proteins (Proteins, Gene)
5.	Phosphotransferases (Kinase)
6.	Immunologic Factors (Immunomodulators)

Related Therapies and Procedures

1.	Therapeutics