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carvacryl acetate

a derivative of carvacrol that reduces nociceptive and inflammatory response in mice; structure in first source

Networked: 6 relevant articles (2 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Monoterpenes: 522
      - carvacryl acetate: 6

Experts

1.	Sousa, Damião P: 2 articles (12/2017 - 01/2014)
2.	Costa, Luciana Muratori: 2 articles (01/2015 - 11/2013)
3.	Pires, Lúcio Fernandes: 2 articles (01/2015 - 11/2013)
4.	Silva, Oskar Almeida: 2 articles (01/2015 - 11/2013)
5.	de Almeida, Antonia Amanda Cardoso: 2 articles (01/2015 - 11/2013)
6.	de Freitas, Rivelilson Mendes: 2 articles (01/2015 - 11/2013)
7.	de Sousa, Damião Pergentino: 2 articles (01/2015 - 11/2013)
8.	Bezerra-Filho, Carlos S M: 1 article (11/2021)
9.	Cajas, Rayssa A: 1 article (11/2021)
10.	Carnaúba, Paulo U: 1 article (11/2021)

Related Diseases

1.	Infections 11/01/2021 - "In an animal with patent infection, a single oral dose of carvacryl acetate (100, 200, or 400 mg/kg) caused a significant reduction in worm burden (30-40%). " 11/01/2021 - "Similar to praziquantel, carvacryl acetate 400 mg/kg had low efficacy in pre-patent infection. " 11/01/2021 - "This study reports the anthelmintic evaluation of carvacryl acetate, a derivative of the terpene carvacrol, against Schistosoma mansoni ex vivo and in a schistosomiasis animal model harboring either adult (patent infection) or juvenile (prepatent infection) parasites. "
2.	Mucositis 12/01/2017 - "Carvacryl acetate is a promising anti-inflammatory and antioxidant agent, a fact confirmed through observations of its interactions with TRPA1 in CPT-11-induced intestinal mucositis in mice." 12/01/2017 - "We aimed to determine whether carvacryl acetate acts as a TRPA1 receptor agonist and its effects against irinotecan (CPT-11) induced intestinal mucositis in mice. " 12/01/2017 - "Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice." 12/01/2017 - "Eight amino acids residues in TRPA1 established stable interactions with carvacryl acetate, which led to pharmacological efficacy against CPT-11-induced intestinal mucositis via reduction of both neutropenia and bacteremia, increase in villi height and crypt depth, decrease in pro-inflammatory cytokines (interleukin-1β, keratinocyte chemoattractant and tumour necrosis factor-α) and decrease in malondialdehyde and nitric oxide metabolite levels in the jejunum. "
3.	Bacteremia 12/01/2017 - "Eight amino acids residues in TRPA1 established stable interactions with carvacryl acetate, which led to pharmacological efficacy against CPT-11-induced intestinal mucositis via reduction of both neutropenia and bacteremia, increase in villi height and crypt depth, decrease in pro-inflammatory cytokines (interleukin-1β, keratinocyte chemoattractant and tumour necrosis factor-α) and decrease in malondialdehyde and nitric oxide metabolite levels in the jejunum. "
4.	Schistosomiasis mansoni 11/01/2021 - "Efficacy of carvacryl acetate in vitro and following oral administration to mice harboring either prepatent or patent Schistosoma mansoni infections."
5.	Neutropenia 12/01/2017 - "Eight amino acids residues in TRPA1 established stable interactions with carvacryl acetate, which led to pharmacological efficacy against CPT-11-induced intestinal mucositis via reduction of both neutropenia and bacteremia, increase in villi height and crypt depth, decrease in pro-inflammatory cytokines (interleukin-1β, keratinocyte chemoattractant and tumour necrosis factor-α) and decrease in malondialdehyde and nitric oxide metabolite levels in the jejunum. "

Related Drugs and Biologics

1.	Monoterpenes (Monoterpenoids)
2.	Esters
3.	Amino Acids
4.	Cytokines
5.	Nitric Oxide (Nitrogen Monoxide)
6.	Malondialdehyde (Propanedial)
7.	Interleukins
8.	Chemotactic Factors
9.	Irinotecan (Camptosar)
10.	carvacrol

Related Therapies and Procedures

1.	Oral Administration