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ATI-5261

stimulates efflux of cholesterol from cells

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - ATI-5261: 2
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - ATI-5261: 2
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - ATI-5261: 2

Experts

1.	Chen, Ruiying: 1 article (01/2018)
2.	Liao, Shutan: 1 article (01/2018)
3.	Wu, Hao: 1 article (01/2018)
4.	Azhar, Salman: 1 article (06/2010)
5.	Bielicki, John K: 1 article (06/2010)
6.	Cortez, Yuan: 1 article (06/2010)
7.	Johansson, Jan: 1 article (06/2010)
8.	Narayanaswami, Vasanthy: 1 article (06/2010)
9.	Patel, Arti: 1 article (06/2010)
10.	Zhang, Haiyan: 1 article (06/2010)

Related Diseases

1.	Atherosclerosis 06/01/2010 - "Treatment of fat-fed LDLR(-/-) mice with daily intraperitoneal injections of ATI-5261 (30 mg/kg) for 6 weeks reduced atherosclerosis by 30%, as judged by lesion area covering the aorta (7.9 +/- 2 vs.11.3 +/- 2.5% control, P = 0.011) and lipid-content of aortic sinus plaque (25 +/- 5.8 vs. 33 +/- 4.9% control, P = 0.014). " 06/01/2010 - "In summary, relatively short-term treatment of mice with the potent cholesterol efflux peptide ATI-5261 reduced substantial atherosclerosis. " 06/01/2010 - "Anti-atherosclerosis activity of ATI-5261 was evaluated in LDLR(-/-) and apolipoprotein (apo)E(-/-) mice approximately 5-7 months of age, following 13-18 weeks on a high-fat Western diet (HFWD). "
2.	Pre-Eclampsia (Preeclampsia) 01/01/2018 - "Apolipoprotein A1 mimetic peptide ATI-5261 reverses arterial stiffness at late pregnancy and early postpartum in a COMT-/- mouse model of preeclampsia."

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Apolipoprotein A-I (Apolipoprotein A1)
3.	Lipids
4.	Cholesterol
5.	Apolipoproteins E (ApoE)
6.	Apolipoproteins

Related Therapies and Procedures

1.	Intraperitoneal Injections