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2- debenzoyl- 2- (3- azidobenzyl)- 10- propionyldocetaxel

structure in first source

Also Known As:

Yg-3-46a

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - Taxoids: 2650
        Paclitaxel: 22016
        2-debenzoyl-2-(3-azidobenzyl)-10-propionyldocetaxel: 1
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclodecanes
        Taxoids: 2650
        Paclitaxel: 22016
        2-debenzoyl-2-(3-azidobenzyl)-10-propionyldocetaxel: 1

Experts

1.	Cai, Pei: 1 article (12/2013)
2.	Fang, Wei-Shuo: 1 article (12/2013)
3.	Lu, Peihua: 1 article (12/2013)
4.	Sharom, Frances J: 1 article (12/2013)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2013 - "A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro."
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/01/2013 - "A novel semisynthetic taxane, 2-debenzoyl-2-(3-azidobenzyl)-10-propionyldocetaxel (Yg-3-46a) was shown to be highly cytotoxic to breast cancer cell lines MCF-7 and MCF/ADR which overexpressed P-gp via long term culture with doxorubicin, and cervical cancer cell lines Hela and Hela/βIII which overexpressed βIII-tubulin via stable transfection with TUBB3 gene. "
3.	Breast Neoplasms (Breast Cancer) 12/01/2013 - "A novel semisynthetic taxane, 2-debenzoyl-2-(3-azidobenzyl)-10-propionyldocetaxel (Yg-3-46a) was shown to be highly cytotoxic to breast cancer cell lines MCF-7 and MCF/ADR which overexpressed P-gp via long term culture with doxorubicin, and cervical cancer cell lines Hela and Hela/βIII which overexpressed βIII-tubulin via stable transfection with TUBB3 gene. "

Related Drugs and Biologics

1.	Member 1 Subfamily B ATP Binding Cassette Transporter
2.	Tubulin
3.	Doxorubicin (Adriamycin)
4.	taxane