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MDC-1112

structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Valerates: 135
      - Pentanoic Acids: 1
        Valproic Acid: 9766
        MDC-1112: 2
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - MDC-1112: 2
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Valerates: 135
      - Pentanoic Acids: 1
        Valproic Acid: 9766
        MDC-1112: 2

Experts

1.	Luo, Dingyuan: 2 articles (01/2020 - 12/2019)
2.	Mackenzie, Gerardo G: 2 articles (01/2020 - 12/2019)
3.	Rigas, Basil: 2 articles (01/2020 - 12/2019)
4.	Digiovanni, Matthew G: 1 article (01/2020)
5.	Lacomb, Joseph F: 1 article (01/2020)
6.	Wei, Ran: 1 article (01/2020)
7.	Williams, Jennie L: 1 article (01/2020)
8.	Bartels, Lauren E: 1 article (12/2019)
9.	Bonfiglio, James V: 1 article (12/2019)
10.	Fletchinger, Teresa C: 1 article (12/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "In vivo, MDC-1112 and GEM, given alone, reduced patient-derived pancreatic tumor xenograft growth by 58% and 87%, respectively; whereas MDC-1112/GEM combination reduced tumor growth by 94%, inducing tumor stasis. " 01/01/2020 - "MDC-1112 alone strongly reduced patient-derived pancreatic tumor xenograft growth, and extended survival of LSL-KrasG12D/+; LSL-Trp53R172H/+; Pdx1-Cre (KPC) mice. "
2.	Glioblastoma (Glioblastoma Multiforme) 12/31/2019 - "The novel agent MDC-1112 is an effective anticancer agent in multiple animal models of glioblastoma, and its mechanism of action involves the inhibition of STAT3 phosphorylation, primarily at its Serine 727 residue."

Related Drugs and Biologics

1.	Serine (L-Serine)
2.	Antineoplastic Agents (Antineoplastics)