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skimmin

from Hydrangea paniculata; suppresses the streptozotocin-induced diabetic nephropathy in wistar rats

Networked: 9 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        skimmin: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        skimmin: 9

Experts

1.	Chen, Xiaoguang: 2 articles (01/2013 - 10/2012)
2.	Li, Yan: 2 articles (01/2013 - 10/2012)
3.	Yang, Jingzhi: 2 articles (01/2013 - 10/2012)
4.	Zhang, Dongming: 2 articles (01/2013 - 10/2012)
5.	Zhang, Sen: 2 articles (01/2013 - 10/2012)
6.	Cui, Jingming: 1 article (05/2022)
7.	Fu, Xiaoyan: 1 article (05/2022)
8.	Su, Manxia: 1 article (05/2022)
9.	Zhao, Jia: 1 article (05/2022)
10.	Liang, Rui-Jing: 1 article (02/2021)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 10/05/2012 - "Skimmin, a major active ingredient from Hydrangea paniculata, was considered to have the possible preventive effect on the progression of diabetic nephropathy based on the traditional Chinese medicine. " 10/05/2012 - "This study suggests that the skimmin can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway." 02/01/2021 - "Skimmin, a natural coumarin derivate, has been showed to be protective against experimental diabetic nephropathy; however, its protective effect on diabetic cardiomyopathy (DCM) is not clarified. " 10/05/2012 - "Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats."
2.	Diabetic Cardiomyopathies 02/01/2021 - "Skimmin protects diabetic cardiomyopathy in streptozotocin-induced diabetic rats." 02/01/2021 - "Skimmin, a natural coumarin derivate, has been showed to be protective against experimental diabetic nephropathy; however, its protective effect on diabetic cardiomyopathy (DCM) is not clarified. "
3.	Myocardial Infarction 01/01/2023 - "Skimmin ameliorates cardiac function via the regulation of M2 macrophages in a myocardial infarction mouse model."
4.	Insulin Resistance 01/01/2020 - "In conclusion, skimmin can improve the insulin resistance by increasing glucose uptake and decreasing glucose output in vitro and in vivo." 01/01/2020 - "Skimmin Improves Insulin Resistance via Regulating the Metabolism of Glucose: In Vitro and In Vivo Models." 01/01/2020 - "Herein, we found that skimmin relieved the palmitic acid and high-fat and high sugar-induced insulin resistance. "
5.	Fibrosis (Cirrhosis) 10/05/2012 - "This study suggests that the skimmin can suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway." 02/01/2021 - "Skimmin also reduced cardiac fibrosis, and decreased proinflammation cytokines in cardiac tissues. "

Related Drugs and Biologics

1.	coumarin
2.	Palmitic Acid (Hexadecanoic Acid)
3.	Sugars
4.	Anti-Inflammatory Agents (Anti-Inflammatories)
5.	Streptozocin (Streptozotocin)
6.	Coumarins
7.	Losartan (Cozaar)
8.	Cytokines
9.	Urea (Carbamide)
10.	Nitrogen

Related Therapies and Procedures

1.	Chinese Traditional Medicine (Traditional Chinese Medicine)