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1,2-bis(isothiazol-5-yl)disulfane

structure in first source

Also Known As:

NU9056

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 1,2-bis(isothiazol-5-yl)disulfane: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 1,2-bis(isothiazol-5-yl)disulfane: 5

Experts

1.	Chen, Lu: 1 article (01/2021)
2.	Lin, Guoxin: 1 article (01/2021)
3.	Peng, Qianyi: 1 article (01/2021)
4.	Qing, Wenxiang: 1 article (01/2021)
5.	Yi, Zexiong: 1 article (01/2021)
6.	Zhou, Fan: 1 article (01/2021)
7.	Bernard-Gallon, Dominique: 1 article (10/2020)
8.	Bignon, Yves-Jean: 1 article (10/2020)
9.	Boisnier, Tiphanie: 1 article (10/2020)
10.	Houfaf Khoufaf, Fatma Zohra: 1 article (10/2020)

Related Diseases

1.	Cognitive Dysfunction 01/01/2021 - "Results: NU9056 improved the survival rate of mice and alleviated LPS-induced cognitive impairment, anxiety, and depression in vivo. " 01/01/2021 - "Conclusions: NU9056 might effectively alleviate LPS-induced cognitive impairment and emotional disorder in experimental mice by inhibiting the NLRP3 inflammasome. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2012 - "Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer." 01/01/2012 - "Based on the activity of NU9056 and the specificity of the compound towards Tip60 relative to other HAT enzymes, these chemical biology studies have identified Tip60 as a potential therapeutic target for the treatment of prostate cancer." 01/01/2012 - "NU9056 treatment inhibited cellular proliferation in a panel of prostate cancer cell lines (50% growth inhibition, 8-27 µM) and induced apoptosis via activation of caspase 3 and caspase 9 in a concentration- and time-dependent manner. "
3.	Breast Neoplasms (Breast Cancer) 10/01/2020 - "In this study, the inhibition of the residual activity of TIP60 in breast cancer cell lines was investigated by using two chemical inhibitors, TH1834 and NU9056, first on the acetylation of the specific target, lysine 4 of histone 3 (H3K4) by immunoblotting, and second, by chromatin immunoprecipitation (ChIP)-qPCR (-quantitative Polymerase Chain Reaction). "
4.	Anaplastic Thyroid Carcinoma 01/01/2022 - "KAT5 Inhibitor NU9056 Suppresses Anaplastic Thyroid Carcinoma Progression through c-Myc/miR-202 Pathway."
5.	Inflammation (Inflammations) 11/01/2017 - "Moreover, the Tip60/HAT inhibitor, NU9056, was able to block EtOH-induced H4K12ac, enhancing the effect of EtOH on IL-15, RANTES, TGF-β1, and TNF-α cytokines while restoring MCP-2 levels, suggesting that H4K12ac may be playing a major role during inflammation and may serve as an inflammation regulator or a cellular stress response mechanism under chronic alcohol conditions."

Related Drugs and Biologics

1.	Lysine (L-Lysine)
2.	Histones (Histone)
3.	Enzymes
4.	Chromatin
5.	Inflammasomes
6.	Caspase 9
7.	Caspase 3 (Caspase-3)
8.	Interleukin-15 (Interleukin 15)
9.	Chemokine CCL5
10.	Cytokines