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4- (chlorophenyl)- (2- (3,5- dimethylpyrazol- 1- yl)- 9- methyl- 9H- purin- 6- yl)amine

positive modulator of types 2 and 3 small conductance calcium-activated potassium channels; structure in first source

Also Known As:

NS13001

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - 4-(chlorophenyl)-(2-(3,5-dimethylpyrazol-1-yl)-9-methyl-9H-purin-6-yl)amine: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Adenine: 2120
        4-(chlorophenyl)-(2-(3,5-dimethylpyrazol-1-yl)-9-methyl-9H-purin-6-yl)amine: 2

Experts

1.	Coleman, Nichole: 1 article (10/2013)
2.	Garing, April Lourdes A: 1 article (10/2013)
3.	Lam, Jenny: 1 article (10/2013)
4.	Wulff, Heike: 1 article (10/2013)
5.	Bezprozvanny, Ilya: 1 article (10/2012)
6.	Christophersen, Palle: 1 article (10/2012)
7.	Egorova, Polina: 1 article (10/2012)
8.	Eriksen, Birgitte L: 1 article (10/2012)
9.	Hougaard, Charlotte: 1 article (10/2012)
10.	Jacobsen, Thomas A: 1 article (10/2012)

Related Diseases

1.	Cerebellar Ataxia (Dysmetria) 10/26/2012 - "We conclude that SK2 channels constitute a therapeutic target for SCA2 treatment and that the developed selective SK2/3 modulator NS13001 holds promise as a potential therapeutic agent for treatment of SCA2 and possibly other cerebellar ataxias." 10/01/2013 - "Genetic KCa2 channel suppression in deep cerebellar neurons induces ataxia, while KCa2 activators like 1-EBIO, SKA-31 and NS13001 improve motor deficits in mouse models of episodic ataxia (EA) and spinal cerebellar ataxia (SCA). "
2.	Ataxia (Dyssynergia) 10/01/2013 - "Genetic KCa2 channel suppression in deep cerebellar neurons induces ataxia, while KCa2 activators like 1-EBIO, SKA-31 and NS13001 improve motor deficits in mouse models of episodic ataxia (EA) and spinal cerebellar ataxia (SCA). "
3.	Episodic Ataxia 10/01/2013 - "Genetic KCa2 channel suppression in deep cerebellar neurons induces ataxia, while KCa2 activators like 1-EBIO, SKA-31 and NS13001 improve motor deficits in mouse models of episodic ataxia (EA) and spinal cerebellar ataxia (SCA). "

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