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PF-04880594

a RAF inhibitor; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - PF-04880594: 1
  - Pyrimidines: 510
    - PF-04880594: 1

Experts

1.	Bagrodia, Shubha: 1 article (10/2012)
2.	Burns-Naas, Leigh Ann: 1 article (10/2012)
3.	Evering, Winston: 1 article (10/2012)
4.	Hu, Wenyue: 1 article (10/2012)
5.	John-Baptiste, Annette: 1 article (10/2012)
6.	Marroquin, Lisa D: 1 article (10/2012)
7.	Palmer, Cynthia L: 1 article (10/2012)
8.	Smeal, Tod: 1 article (10/2012)
9.	Torti, Vince R: 1 article (10/2012)
10.	Troche, Gabriel: 1 article (10/2012)

Related Diseases

1.	Hyperplasia 10/01/2012 - "We showed that the RAF inhibitor PF-04880594 induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. " 10/01/2012 - "The complete inhibition of hyperplasia by MEK inhibitor in epithelial tissues does not seem to reduce RAF inhibitor efficacy and, in fact, allows doubling of the PF-04880594 dose without toxicity usually associated with such doses. " 10/01/2012 - "Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901."
2.	Flushing 10/01/2012 - "We also showed that PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells, suggesting a possible mechanism for the skin flushing observed in dogs. "

Related Drugs and Biologics

1.	Mitogen-Activated Protein Kinase Kinases (MEKs)
2.	Interleukin-8 (Interleukin 8)
3.	Cytokines
4.	mirdametinib