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2-acetyloxybenzoic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester

releases hydrogen sulfide; structure in first source

Also Known As:

ACS14

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sparatore, Anna: 4 articles (12/2012 - 12/2010)
2.	Del Soldato, Piero: 2 articles (12/2012 - 12/2010)
3.	Han, Xiao: 1 article (07/2019)
4.	Huang, Nan: 1 article (07/2019)
5.	Wang, Hao-Hao: 1 article (07/2019)
6.	Yang, Ping: 1 article (07/2019)
7.	Zhao, An-Sha: 1 article (07/2019)
8.	Zou, Dan: 1 article (07/2019)
9.	Fan, Yuqi: 1 article (12/2012)
10.	Gu, Ting: 1 article (12/2012)

Related Diseases

1.	Atherosclerotic Plaque (Atheroma) 12/15/2012 - "We found that ACS14, but not aspirin, significantly downregulated CX3CR1 expression in atherosclerotic plaques. " 12/15/2012 - "The present study investigated the effect of a novel H(2)S-releasing aspirin, ACS14 (2-acetyloxybenzoic acid 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester), on atherosclerotic plaques in fat-fed apoE(-/-) mice and the underlying mechanism with respect to CX3C chemokine receptor 1 (CX3CR1) in macrophages. "
2.	Atherosclerosis 12/15/2012 - "These data indicate that ACS14 may prevent the progression of atherosclerosis by downregulating macrophage CX3CR1 expression via a PPAR-γ-dependent mechanism." 12/15/2012 - "ACS14 considerably impeded the formation and development of atherosclerosis as compared to a molar equivalent dose of aspirin. " 12/15/2012 - "Twelve weeks after ACS14 or aspirin treatment, mice were sacrificed to evaluate the extent of atherosclerosis and CX3CR1 expression in brachiocephalic artery (BCA). " 12/15/2012 - "Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice."
3.	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/01/2010 - "We investigated the effects of the hydrogen sulfide (H₂S)-releasing derivatives of aspirin (ACS14) and salicylic acid (ACS21) in a rat model of metabolic syndrome induced by glutathione (GSH) depletion, causing hypertension and other pathological cardiovascular alterations. "
4.	Thrombosis (Thrombus) 12/01/2012 - "ACS14 led to a significantly longer arterial occlusion time after light-dye-induced endothelial injury as well as decreased thrombus formation after ferric chloride-induced injury in the carotid artery. "
5.	Necrosis 07/01/2019 - "Meanwhile, the tumour necrosis factor alpha release in macrophage was also declined by 15% in ACS14 groups than the others. "

Related Drugs and Biologics

1.	Aspirin (Acetylsalicylic Acid)
2.	Apolipoproteins E (ApoE)
3.	CX3C Chemokine Receptor 1
4.	Hydrogen Sulfide (Sulfide, Hydrogen)
5.	Peroxisome Proliferator-Activated Receptors (PPAR)
6.	Salicylic Acid (2 Hydroxybenzoic Acid)
7.	Thromboxanes
8.	Insulin (Novolin)
9.	Glutathione (Reduced Glutathione)
10.	Coloring Agents (Dyes)