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N- (2- methylfuro(2,3- d)pyrimidin- 4- yl)acrylamide

inhibits the NF-kappaB signaling pathway; structure in first source

Also Known As:

HK-156

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acrylamides: 12
    - N-(2-methylfuro(2,3-d)pyrimidin-4-yl)acrylamide: 1
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - Acrylamides: 12
        N-(2-methylfuro(2,3-d)pyrimidin-4-yl)acrylamide: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - N-(2-methylfuro(2,3-d)pyrimidin-4-yl)acrylamide: 1

Experts

1.	Ding, Kan: 1 article (09/2012)
2.	Fang, Jian-Ping: 1 article (09/2012)
3.	Hu, You-Hong: 1 article (09/2012)
4.	Li, Jie: 1 article (09/2012)
5.	Liao, Wen-Feng: 1 article (09/2012)
6.	Liu, Yang: 1 article (09/2012)

Related Diseases

1.

Sepsis (Septicemia)

09/01/2012 - "HK-156 may therefore be a useful therapeutic agent for treating sepsis."
09/01/2012 - "HK-156 inhibits LPS-induced activation of NF-κB signaling by suppressing the phosphorylation of TAK1 in vitro, and exerts beneficial effects in a mouse sepsis model. "
09/01/2012 - "In mouse models of sepsis, pre-injection of HK-156 (50 mg/kg, iv) significantly inhibited TNFα production and reduced the mortality caused by the lethal dose of LPS. "
09/01/2012 - "A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis."

Related Drugs and Biologics

1.	Lipopolysaccharides