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4- (4- (hydroxymethyl)- 3- methyl- 2,5- dioxo- 4- phenylimidazolidin- 1- yl)- 2- (trifluoromethyl)benzonitrile

structure in first source

Also Known As:

GLPG0492

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - Imidazolidines: 39
        Hydantoins: 306
        4-(4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenylimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile: 2

Experts

1.	Namour, Florence: 2 articles (09/2014 - 06/2013)
2.	Auberval, Marielle: 1 article (09/2014)
3.	Blanqué, Roland: 1 article (09/2014)
4.	Clément-Lacroix, Philippe: 1 article (09/2014)
5.	Cottereaux, Céline: 1 article (09/2014)
6.	Delerive, Philippe: 1 article (09/2014)
7.	Lepescheux, Liên: 1 article (09/2014)
8.	Merciris, Didier: 1 article (09/2014)
9.	Minet, Dominique: 1 article (09/2014)
10.	Camerino, Giulia Maria: 1 article (06/2013)

Related Diseases

1.	Sarcopenia 06/01/2013 - "We focused on GLPG0492, a new non-steroidal selective androgen receptor modulator that is currently under development for musculo-skeletal diseases such as sarcopenia and cachexia. "
2.	Paralysis (Palsy) 09/03/2014 - "Taken together, these results unveil the potential of GLPG0492, a non-steroidal SARM, as treatment for, at least, musculo-skeletal atrophy consecutive to coma, paralysis, or limb immobilization."
3.	Muscular Dystrophies (Muscular Dystrophy) 06/01/2013 - "GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy."
4.	Muscular Atrophy (Muscle Atrophy) 09/03/2014 - "GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. " 09/03/2014 - "Our objective was to demonstrate the activity of SARM molecule (GLPG0492) on a immobilization muscle atrophy mouse model as compared to testosterone propionate (TP) and to identify putative biomarkers in the plasma compartment that might be related to muscle function and potentially translated into the clinical space. "
5.	Hypertrophy 09/03/2014 - "GLPG0492 treatment partially prevents immobilization-induced muscle atrophy with a trend to promote muscle fiber hypertrophy in a dose-dependent manner. "

Related Drugs and Biologics

1.	Testosterone Propionate
2.	Biomarkers (Surrogate Marker)
3.	Androgen Receptors (Androgen Receptor)