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RKI-1447

an antineoplastic agent that inhibits ROCK1 and ROCK2; structure in first source

Networked: 6 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - RKI-1447: 6
- Sulfur Compounds: 278
  - Thiazoles: 392
    - RKI-1447: 6
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - RKI-1447: 6

Experts

1.	Jiang, Wentao: 1 article (02/2020)
2.	Wang, Jinshan: 1 article (02/2020)
3.	Chang, Hong: 1 article (01/2020)
4.	Chen, Hui: 1 article (01/2020)
5.	Chen, Qin: 1 article (01/2020)
6.	Huang, Yingpeng: 1 article (01/2020)
7.	Li, Liyi: 1 article (01/2020)
8.	Li, Pihong: 1 article (01/2020)
9.	Lu, Mingdong: 1 article (01/2020)
10.	Yu, Yaojun: 1 article (01/2020)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 02/06/2020 - "CONCLUSIONS In a mouse model of NAFLD, RKI-1447 inhibited ROCK and modulated insulin resistance, oxidative stress, and inflammation through the ROCK/TLR4/TBK1/IRF3 pathway." 02/06/2020 - "The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid." 02/06/2020 - "BACKGROUND This study aimed to investigate the effects of RKI-1447, a selective inhibitor of Rho-associated ROCK kinases, in a mouse model of nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet, and in oleic acid-treated HepG2 human hepatocellular carcinoma cells in vitro. " 02/06/2020 - "RKI-1447 reduced the histological changes in the mouse model of NAFLD in mice fed a high-fat diet and significantly inhibited the generations of triglyceride, IL-6, and TNF-alpha. " 02/06/2020 - "RESULTS In the mouse model of NAFLD, RKI-1447 reduced insulin resistance and the levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol, triglyceride, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), malondialdehyde (MDA), and superoxide dismutase (SOD). "
2.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2020 - "Taken together, this study demonstrated that inhibition of ROCK signaling pathway by RKI-1447 could suppress CRC via cytoskeleton associated mitochondrial dysfunction and cellular bioenergetics disruption. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/06/2020 - "The HepG2 human hepatocellular carcinoma cells were treated with or without RKI-1447 for 2 h and treated with oleic acid for 24 h. " 02/06/2020 - "The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid." 02/06/2020 - "BACKGROUND This study aimed to investigate the effects of RKI-1447, a selective inhibitor of Rho-associated ROCK kinases, in a mouse model of nonalcoholic fatty liver disease (NAFLD) induced by a high-fat diet, and in oleic acid-treated HepG2 human hepatocellular carcinoma cells in vitro. "
4.	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/01/2019 - "This study investigated the hypotensive effect of RKI-1447, a Rho kinase inhibitor, in a porcine ex vivo pigmentary glaucoma model. "
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics." 12/24/2019 - "The approach was validated with the breast cancer cell line MDA-MB-231, the colorectal cancer cells HCT116, and the prostate cancer cells PC3; and known drugs, respectively RKI-1447, Docetaxel, and Mitoxantrone. "

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	rho-Associated Kinases
3.	Oleic Acid (Oleate)
4.	Mitogen-Activated Protein Kinase Kinases (MEKs)
5.	Ribosomal Protein S6 Kinases (S6 Kinase)
6.	Interleukin-6 (Interleukin 6)
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
8.	Triglycerides (Triacylglycerol)
9.	Superoxide Dismutase
10.	Mitoxantrone (Novantrone)