HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

KPT-185

binds CRM1 to inhibit nuclear export; has antineoplastic activity

Networked: 12 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - KPT-185: 12
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - KPT-185: 12

Experts

1.	Shacham, Sharon: 7 articles (01/2018 - 02/2013)
2.	Landesman, Yosef: 5 articles (09/2019 - 06/2013)
3.	Kauffman, Michael: 5 articles (03/2017 - 02/2013)
4.	Aboukameel, Amro: 3 articles (09/2019 - 02/2013)
5.	Azmi, Asfar S: 3 articles (09/2019 - 02/2013)
6.	Baloglu, Erkan: 2 articles (09/2019 - 01/2018)
7.	Philip, Philip A: 2 articles (09/2019 - 02/2013)
8.	Senapedis, William: 2 articles (09/2019 - 11/2015)
9.	McCauley, Dilara: 2 articles (03/2017 - 03/2014)
10.	Han, Xiaohong: 2 articles (01/2015 - 01/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2014 - "Further studies will assess anti-tumor activity of KPT-185 in a clinical trial for NSCLC patients." 01/01/2014 - "The current study demonstrated the anti-tumor effects of KPT-185 in NSCLC cells, including EGFR-TKI-resistant NSCLC cell lines. " 01/01/2015 - "KPT-185 displayed potent antiproliferative properties and induced cell-cycle arrest and apoptosis in several NHL cell lines and patients' tumor cells. " 06/15/2014 - "Our lead SINE KPT-185 inhibits PDAC cell growth, cell migration, tumor invasion and induces apoptosis and G2-M cell cycle arrest in low nano molar range (IC50s~150 nM). " 06/15/2014 - "Mechanistically we demonstrate that the activity of KPT-185 is associated with nuclear retention of Fbw7; which degrades nuclear Notch-1 leading to decreased tumor promoting markers such as C-Myc, Cyclin-D1, Hes1 and VEGF. "
2.	Stomach Neoplasms (Stomach Cancer) 01/01/2018 - "In the current study, we investigated the anti-tumor efficacy of selective inhibitors of nuclear export (SINE) compounds KPT-185, KTP-276 and clinical stage selinexor (KPT-330) in gastric cancer. " 09/28/2019 - "Anti-tumor activity was observed with specific inhibitor of nuclear export (SINE) compounds (selinexor/XPOVIO), second-generation compound KPT-8602/eltanexor, KPT-185 and +ve control Leptomycin B in three distinct gastric cancer cell lines. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 06/01/2013 - "We tested the efficacy of the CRM1 inhibitors KPT-185 and 251 in several renal cell carcinoma cell lines and in a renal cell carcinoma xenograft model. " 06/01/2013 - "KPT-185 attenuated CRM1 and showed increased cytotoxicity in renal cell carcinoma cells in vitro with evidence of increased apoptosis as well as cell cycle arrest. " 06/01/2013 - "KPT-185 caused p53 and p21 to remain primarily in the nucleus in all renal cell carcinoma cell lines, suggesting that the mechanism of action of these compounds depends on tumor suppressor protein localization. "
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2014 - "This study assessed the therapeutic efficiency of the novel CRM1 inhibitor KPT-185 on non-small cell lung cancer (NSCLC). "
5.	Triple Negative Breast Neoplasms 03/01/2014 - "We investigated the antitumor mechanisms of the drug-like selective inhibitors of nuclear export (SINE) XPO1 antagonists KPT-185, KPT-251 KPT-276, and KPT-330 in estrogen receptor-positive and triple-negative breast cancer (TNBC) cell lines and xenograft models of human breast tumors. "

Related Drugs and Biologics

1.	selinexor
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)
4.	Cyclin D1
5.	RNA (Ribonucleic Acid)
6.	Estrogen Receptors
7.	Proteins (Proteins, Gene)
8.	Platinum
9.	KPT-276
10.	5- (2'- naphthyl)- 7- 4- chlorophenyl- (2,3,6,8- tetrahydro)pyrrolo- (3,4- e)(1,4)- diazepine- 6- thioxo- 8- (1H,7H)one