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2- (4- (4- methyl- 6- phenylpyridazin- 3- yl)piperazin- 1- yl)pyrimidine

attenuates proinflammatory cytokine production

Also Known As:

MW-151; MW01-2-151SRM

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 2-(4-(4-methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine: 2
  - Pyridazines: 11
    - 2-(4-(4-methyl-6-phenylpyridazin-3-yl)piperazin-1-yl)pyrimidine: 2

Experts

1.	Augner, David P: 1 article (09/2014)
2.	Cooper, Jonathan D: 1 article (09/2014)
3.	Dearborn, Joshua T: 1 article (09/2014)
4.	Fowler, Stephen C: 1 article (09/2014)
5.	Macauley, Shannon L: 1 article (09/2014)
6.	Pearse, Yewande: 1 article (09/2014)
7.	Roberts, Marie S: 1 article (09/2014)
8.	Sands, Mark S: 1 article (09/2014)
9.	Shyng, Charles: 1 article (09/2014)
10.	Watterson, D Martin: 1 article (09/2014)

Related Diseases

1.	Neuroinflammatory Diseases 05/01/2013 - "MW-151 mitigated radiation-induced neuroinflammation at both early and late time points post-WBI, selectively mitigated the deleterious effects of irradiation on hippocampal neurogenesis, and potently mitigated radiation-induced deficits of novel object recognition consolidation and of long-term potentiation induction and maintenance. " 05/01/2013 - "We hypothesized that inhibiting neuroinflammation using MW01-2-151SRM (MW-151), a selective inhibitor of proinflammatory cytokine production, might mitigate these deleterious radiation effects by preserving/restoring hippocampal neurogenesis. " 09/24/2014 - "MW01-2-151SRM (MW151) is a blood-brain barrier penetrant, small-molecule anti-neuroinflammatory that attenuates glial cytokine upregulation in models of neuroinflammation such as traumatic brain injury, Alzheimer's disease, and kainic acid toxicity. "
2.	Alzheimer Disease (Alzheimer's Disease) 09/24/2014 - "MW01-2-151SRM (MW151) is a blood-brain barrier penetrant, small-molecule anti-neuroinflammatory that attenuates glial cytokine upregulation in models of neuroinflammation such as traumatic brain injury, Alzheimer's disease, and kainic acid toxicity. "
3.	Traumatic Brain Injuries (Traumatic Brain Injury) 09/24/2014 - "MW01-2-151SRM (MW151) is a blood-brain barrier penetrant, small-molecule anti-neuroinflammatory that attenuates glial cytokine upregulation in models of neuroinflammation such as traumatic brain injury, Alzheimer's disease, and kainic acid toxicity. "

Related Drugs and Biologics

1.	Cytokines
2.	Kainic Acid (Kainate)