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KL001

inhibits degradation of the cryptochrome; structure in first source

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        KL001: 4
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - KL001: 4
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - KL001: 4
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - KL001: 4

Experts

1.	Alagha, M Abdulhadi: 1 article (12/2021)
2.	Katona, Éva: 1 article (12/2021)
3.	Matta, Csaba: 1 article (12/2021)
4.	Takács, Roland: 1 article (12/2021)
5.	Vágó, Judit: 1 article (12/2021)
6.	Zákány, Róza: 1 article (12/2021)
7.	van der Veen, Daan: 1 article (12/2021)
8.	Moskalev, Alexey A: 1 article (08/2021)
9.	Shaposhnikov, Mikhail V: 1 article (08/2021)
10.	Solovev, Ilya A: 1 article (08/2021)

Related Diseases

1.	Starvation 08/20/2021 - "KL001 5 µM solution improved by 9% the mean starvation resistance in male flies (p < 0.01), while median resistance was elevated by 50% (p < 0.0001). " 08/20/2021 - "This phenomenon may suggest the presence of the mechanism associated with improvement of fat body glucose depos' utilization in starvation conditions which is activated by dCRY binding KL001."
2.	Shock 12/01/2021 - "The observed chondrogenesis-promoting effect of the serum shock was likely attributable to its synchronizing effect on the molecular clockwork, as co-application of small molecule modulators (longdaysin and KL001) abolished the stimulating effects on extracellular matrix production and chondrogenic marker gene expression. "
3.	Osteosarcoma (Osteogenic Sarcoma) 04/01/2023 - "Herein, based on KL001, a small molecule that specifically interacts with the clock gene cryptochrome (CRY) functioning at disruption of CR, we fabricated a hollow MnO2 nanocapsule carrying KL001 and photosensitizer BODIPY with the modification of alendronate (ALD) on the surface (H-MnSiO/K&B-ALD) for osteosarcoma (OS) targeting. "
4.	Neoplasms (Cancer) 04/01/2023 - "An orthotopic OS model demonstrated that KL001 significantly enhanced the inhibitory effect of H-MnSiO/K&B-ALD nanoparticles on tumor growth after laser irradiation. "
5.	Glioblastoma (Glioblastoma Multiforme) 10/04/2022 - "SHP656 is an orally available KL001 derivative and has shown efficacy in blood glucose control and inhibition of glioblastoma stem cell (GSC) growth in animal models. "

Related Drugs and Biologics

1.	Solutions
2.	Cryptochromes
3.	Nanocapsules
4.	Alendronate (Alendronate Sodium)
5.	Photosensitizing Agents (Photosensitizers)
6.	Glucose (Dextrose)
7.	longdaysin
8.	4,4- difluoro- 4- bora- 3a,4a- diaza- s- indacene (BODIPY)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Glycemic Control