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3- (5- methoxy- 2- methyl- 1H- indol- 3- yl)- 1- (4- pyridinyl)- 2- propen- 1- one

antineoplastic agent that induces methuosis; structure in first source

Also Known As:

MOMIPP

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - 3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one: 5

Experts

1.	Maltese, William A: 5 articles (01/2020 - 03/2012)
2.	Erhardt, Paul W: 4 articles (01/2020 - 03/2012)
3.	Overmeyer, Jean H: 4 articles (01/2019 - 03/2012)
4.	Trabbic, Christopher J: 3 articles (01/2020 - 01/2014)
5.	Li, Zehui: 2 articles (01/2020 - 01/2019)
6.	Sarver, Jeffrey G: 2 articles (01/2020 - 01/2019)
7.	Robinson, Michael W: 2 articles (01/2014 - 03/2012)
8.	Fakhrabadi, Ehsan Akbari: 1 article (01/2020)
9.	Giri, Paras M: 1 article (01/2020)
10.	Hosier, Corey E: 1 article (01/2020)

Related Diseases

1.	Glioblastoma (Glioblastoma Multiforme) 01/16/2019 - "MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts. " 01/16/2019 - "The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma." 01/16/2019 - "To determine whether the use of methuosis-inducing IPPs might be feasible in a therapeutic context, we quantified the distribution of our lead IPP compound, MOMIPP, in mouse plasma and brain, and tested its ability to inhibit tumor growth in an intracerebral glioblastoma xenograft model. " 03/08/2012 - "The potential significance of these studies is underscored by the finding that MOMIPP effectively reduces the growth and viability of Temozolomide-resistant glioblastoma and doxorubicin-resistant breast cancer cells. "
2.	Neoplasms (Cancer) 01/16/2019 - "To determine whether the use of methuosis-inducing IPPs might be feasible in a therapeutic context, we quantified the distribution of our lead IPP compound, MOMIPP, in mouse plasma and brain, and tested its ability to inhibit tumor growth in an intracerebral glioblastoma xenograft model. " 01/09/2014 - "Previous studies identified an indole-based chalcone, 3-(5-methoxy-2-methylindol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP), that induces methuosis in human cancer cells. " 01/01/2020 - "A new indole based chalcone molecule MOMIPP induced methuosis mediated cell death in gliobastoma and other cancer cell lines. "
3.	Breast Neoplasms (Breast Cancer) 03/08/2012 - "The potential significance of these studies is underscored by the finding that MOMIPP effectively reduces the growth and viability of Temozolomide-resistant glioblastoma and doxorubicin-resistant breast cancer cells. "
4.	Triple Negative Breast Neoplasms 11/06/2017 - "We have conjugated resveratrol, a natural polyphenol, and 3-(5-methoxy, 2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (MOMIPP), a chalcone, to HA with the goal of enhancing drug bioavailability and targeting triple negative breast cancers. "

Related Drugs and Biologics

1.	Chalcone (Benzalacetophenone)
2.	indole
3.	Doxorubicin (Adriamycin)
4.	Temozolomide (Temodar)
5.	Polyphenols
6.	Resveratrol
7.	indolepropanol phosphate (IPP)